Chromosomally integrated human herpesvirus 6: questions and answers
SUMMARY Chromosomally integrated human herpesvirus 6 (ciHHV‐6) is a condition in which the complete HHV‐6 genome is integrated into the host germ line genome and is vertically transmitted in a Mendelian manner. The condition is found in less than 1% of controls in the USA and UK, but has been found...
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| Published in | Reviews in medical virology Vol. 22; no. 3; pp. 144 - 155 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Chichester, UK
John Wiley & Sons, Ltd
01.05.2012
Wiley Periodicals Inc |
| Subjects | |
| Online Access | Get full text |
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| Abstract | SUMMARY
Chromosomally integrated human herpesvirus 6 (ciHHV‐6) is a condition in which the complete HHV‐6 genome is integrated into the host germ line genome and is vertically transmitted in a Mendelian manner. The condition is found in less than 1% of controls in the USA and UK, but has been found at a somewhat higher prevalence in transplant recipients and other patient populations in several small studies. HHV‐6 levels in whole blood that exceed 5.5 log10 copies/ml are strongly suggestive of ciHHV‐6. Monitoring DNA load in plasma and serum is unreliable, both for identifying and for monitoring subjects with ciHHV‐6 due to cell lysis and release of cellular DNA. High HHV‐6 DNA loads associated with ciHHV‐6 can lead to erroneous diagnosis of active infection. Transplant recipients with ciHHV‐6 may be at increased risk for bacterial infection and graft rejection. ciHHV‐6 can be induced to a state of active viral replication in vitro. It is not known whether ciHHV‐6 individuals are put at clinical risk by the use of drugs that have been associated with HHV‐6 reactivation in vivo or in vitro. Nonetheless, we urge careful observation when use of such drugs is indicated in individuals known to have ciHHV‐6. Little is known about whether individuals with ciHHV‐6 develop immune tolerance for viral proteins. Further research is needed to determine the role of ciHHV‐6 in disease. Copyright © 2011 John Wiley & Sons, Ltd. |
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| AbstractList | Chromosomally integrated human herpesvirus 6 (ciHHV-6) is a condition in which the complete HHV-6 genome is integrated into the host germ line genome and is vertically transmitted in a Mendelian manner. The condition is found in less than 1% of controls in the USA and UK, but has been found at a somewhat higher prevalence in transplant recipients and other patient populations in several small studies. HHV-6 levels in whole blood that exceed 5.5 log10 copies/ml are strongly suggestive of ciHHV-6. Monitoring DNA load in plasma and serum is unreliable, both for identifying and for monitoring subjects with ciHHV-6 due to cell lysis and release of cellular DNA. High HHV-6 DNA loads associated with ciHHV-6 can lead to erroneous diagnosis of active infection. Transplant recipients with ciHHV-6 may be at increased risk for bacterial infection and graft rejection. ciHHV-6 can be induced to a state of active viral replication
in vitro
. It is not known whether ciHHV-6 individuals are put at clinical risk by the use of drugs that have been associated with HHV-6 reactivation
in vivo
or
in vitro
. Nonetheless, we urge careful observation when use of such drugs is indicated in individuals known to have ciHHV-6. Little is known about whether individuals with ciHHV-6 develop immune tolerance for viral proteins. Further research is needed to determine the role of ciHHV-6 in disease. Copyright © 2011 John Wiley & Sons, Ltd. SUMMARY Chromosomally integrated human herpesvirus 6 (ciHHV-6) is a condition in which the complete HHV-6 genome is integrated into the host germ line genome and is vertically transmitted in a Mendelian manner. The condition is found in less than 1% of controls in the USA and UK, but has been found at a somewhat higher prevalence in transplant recipients and other patient populations in several small studies. HHV-6 levels in whole blood that exceed 5.5 log10 copies/ml are strongly suggestive of ciHHV-6. Monitoring DNA load in plasma and serum is unreliable, both for identifying and for monitoring subjects with ciHHV-6 due to cell lysis and release of cellular DNA. High HHV-6 DNA loads associated with ciHHV-6 can lead to erroneous diagnosis of active infection. Transplant recipients with ciHHV-6 may be at increased risk for bacterial infection and graft rejection. ciHHV-6 can be induced to a state of active viral replication in vitro. It is not known whether ciHHV-6 individuals are put at clinical risk by the use of drugs that have been associated with HHV-6 reactivation in vivo or in vitro. Nonetheless, we urge careful observation when use of such drugs is indicated in individuals known to have ciHHV-6. Little is known about whether individuals with ciHHV-6 develop immune tolerance for viral proteins. Further research is needed to determine the role of ciHHV-6 in disease. Copyright © 2011 John Wiley & Sons, Ltd. Chromosomally integrated human herpesvirus 6 (ciHHV-6) is a condition in which the complete HHV-6 genome is integrated into the host germ line genome and is vertically transmitted in a Mendelian manner. The condition is found in less than 1% of controls in the USA and UK, but has been found at a somewhat higher prevalence in transplant recipients and other patient populations in several small studies. HHV-6 levels in whole blood that exceed 5.5 log10 copies/ml are strongly suggestive of ciHHV-6. Monitoring DNA load in plasma and serum is unreliable, both for identifying and for monitoring subjects with ciHHV-6 due to cell lysis and release of cellular DNA. High HHV-6 DNA loads associated with ciHHV-6 can lead to erroneous diagnosis of active infection. Transplant recipients with ciHHV-6 may be at increased risk for bacterial infection and graft rejection. ciHHV-6 can be induced to a state of active viral replication in vitro. It is not known whether ciHHV-6 individuals are put at clinical risk by the use of drugs that have been associated with HHV-6 reactivation in vivo or in vitro. Nonetheless, we urge careful observation when use of such drugs is indicated in individuals known to have ciHHV-6. Little is known about whether individuals with ciHHV-6 develop immune tolerance for viral proteins. Further research is needed to determine the role of ciHHV-6 in disease. SUMMARY Chromosomally integrated human herpesvirus 6 (ciHHV‐6) is a condition in which the complete HHV‐6 genome is integrated into the host germ line genome and is vertically transmitted in a Mendelian manner. The condition is found in less than 1% of controls in the USA and UK, but has been found at a somewhat higher prevalence in transplant recipients and other patient populations in several small studies. HHV‐6 levels in whole blood that exceed 5.5 log10 copies/ml are strongly suggestive of ciHHV‐6. Monitoring DNA load in plasma and serum is unreliable, both for identifying and for monitoring subjects with ciHHV‐6 due to cell lysis and release of cellular DNA. High HHV‐6 DNA loads associated with ciHHV‐6 can lead to erroneous diagnosis of active infection. Transplant recipients with ciHHV‐6 may be at increased risk for bacterial infection and graft rejection. ciHHV‐6 can be induced to a state of active viral replication in vitro. It is not known whether ciHHV‐6 individuals are put at clinical risk by the use of drugs that have been associated with HHV‐6 reactivation in vivo or in vitro. Nonetheless, we urge careful observation when use of such drugs is indicated in individuals known to have ciHHV‐6. Little is known about whether individuals with ciHHV‐6 develop immune tolerance for viral proteins. Further research is needed to determine the role of ciHHV‐6 in disease. Copyright © 2011 John Wiley & Sons, Ltd. Chromosomally integrated human herpesvirus 6 (ciHHV-6) is a condition in which the complete HHV-6 genome is integrated into the host germ line genome and is vertically transmitted in a Mendelian manner. The condition is found in less than 1% of controls in the USA and UK, but has been found at a somewhat higher prevalence in transplant recipients and other patient populations in several small studies. HHV-6 levels in whole blood that exceed 5.5 log10 copies/ml are strongly suggestive of ciHHV-6. Monitoring DNA load in plasma and serum is unreliable, both for identifying and for monitoring subjects with ciHHV-6 due to cell lysis and release of cellular DNA. High HHV-6 DNA loads associated with ciHHV-6 can lead to erroneous diagnosis of active infection. Transplant recipients with ciHHV-6 may be at increased risk for bacterial infection and graft rejection. ciHHV-6 can be induced to a state of active viral replication in vitro. It is not known whether ciHHV-6 individuals are put at clinical risk by the use of drugs that have been associated with HHV-6 reactivation in vivo or in vitro. Nonetheless, we urge careful observation when use of such drugs is indicated in individuals known to have ciHHV-6. Little is known about whether individuals with ciHHV-6 develop immune tolerance for viral proteins. Further research is needed to determine the role of ciHHV-6 in disease.Chromosomally integrated human herpesvirus 6 (ciHHV-6) is a condition in which the complete HHV-6 genome is integrated into the host germ line genome and is vertically transmitted in a Mendelian manner. The condition is found in less than 1% of controls in the USA and UK, but has been found at a somewhat higher prevalence in transplant recipients and other patient populations in several small studies. HHV-6 levels in whole blood that exceed 5.5 log10 copies/ml are strongly suggestive of ciHHV-6. Monitoring DNA load in plasma and serum is unreliable, both for identifying and for monitoring subjects with ciHHV-6 due to cell lysis and release of cellular DNA. High HHV-6 DNA loads associated with ciHHV-6 can lead to erroneous diagnosis of active infection. Transplant recipients with ciHHV-6 may be at increased risk for bacterial infection and graft rejection. ciHHV-6 can be induced to a state of active viral replication in vitro. It is not known whether ciHHV-6 individuals are put at clinical risk by the use of drugs that have been associated with HHV-6 reactivation in vivo or in vitro. Nonetheless, we urge careful observation when use of such drugs is indicated in individuals known to have ciHHV-6. Little is known about whether individuals with ciHHV-6 develop immune tolerance for viral proteins. Further research is needed to determine the role of ciHHV-6 in disease. |
| Author | Kuehl, Uwe Pellett, Philip E. Yoshikawa, Tetsushi Montoya, Jose G. Pritchett, Joshua C. Ablashi, Dharam V. Descamps, Vincent Luppi, Mario Caserta, Mary T. Flamand, Louis Mori, Yasuko Ambros, Peter F. Lusso, Paolo Seto, Edward Hall, Caroline B. Rogez, Sylvie Agut, Henri Gautheret-Dejean, Agnès Ward, Katherine N. Kamble, Rammurti T. Loomis, Kristin S. Lassner, Dirk Medveczky, Peter G. Ogata, Masao Lautenschlager, Irmeli Razonable, Raymund R. |
| Author_xml | – sequence: 1 givenname: Philip E. surname: Pellett fullname: Pellett, Philip E. email: ppellett@med.wayne.edu, P. E. Pellett, PhD, Professor, Department of Immunology, and Microbiology, Wayne State University, 6225 Scott Hall, 540 East Canfield Avenue, Detroit, MI 48201. R. Razonable, MD, Associate Professor, Division of Infectious Diseases and Internal Medicine, Mayo Clinic, Rochester, MN 55905., ppellett@med.wayne.edurazonable.raymund@mayo.edu organization: Department of Immunology and Microbiology, Wayne State University School of Medicine, MI, Detroit, USA – sequence: 2 givenname: Dharam V. surname: Ablashi fullname: Ablashi, Dharam V. organization: HHV-6 Foundation, CA, Santa Barbara, USA – sequence: 3 givenname: Peter F. surname: Ambros fullname: Ambros, Peter F. organization: Children's Cancer Research Institute, Vienna, Austria – sequence: 4 givenname: Henri surname: Agut fullname: Agut, Henri organization: Service of Virology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France – sequence: 5 givenname: Mary T. surname: Caserta fullname: Caserta, Mary T. organization: Department of Pediatrics, University of Rochester School of Medicine, NY, Rochester, USA – sequence: 6 givenname: Vincent surname: Descamps fullname: Descamps, Vincent organization: Department of Dermatology, Bichat Claude Bernard Hospital, Paris, France – sequence: 7 givenname: Louis surname: Flamand fullname: Flamand, Louis organization: Rheumatology and Immunology Research Center, Université Laval, Quebec, Canada – sequence: 8 givenname: Agnès surname: Gautheret-Dejean fullname: Gautheret-Dejean, Agnès organization: Service of Virology, Groupe Hospitalier Pitié-Salpêtrière, Paris, France – sequence: 9 givenname: Caroline B. surname: Hall fullname: Hall, Caroline B. organization: Departments of Pediatrics and Medicine, University of Rochester School of Medicine and Dentistry, NY, Rochester, USA – sequence: 10 givenname: Rammurti T. surname: Kamble fullname: Kamble, Rammurti T. organization: Hematology & Oncology, Baylor College of Medicine, TX, Houston, USA – sequence: 11 givenname: Uwe surname: Kuehl fullname: Kuehl, Uwe organization: Cardiology and Pneumonology, Charite University Berlin, Berlin, Germany – sequence: 12 givenname: Dirk surname: Lassner fullname: Lassner, Dirk organization: Institute for Cardiac Diagnosis & Treatment, Berlin, Germany – sequence: 13 givenname: Irmeli surname: Lautenschlager fullname: Lautenschlager, Irmeli organization: Department of Virology, HUSLAB & University of Helsinki, Helsinki, Finland – sequence: 14 givenname: Kristin S. surname: Loomis fullname: Loomis, Kristin S. organization: HHV-6 Foundation, CA, Santa Barbara, USA – sequence: 15 givenname: Mario surname: Luppi fullname: Luppi, Mario organization: University of Modena and Reggio Emilia, Emilia-Romagna, Italy – sequence: 16 givenname: Paolo surname: Lusso fullname: Lusso, Paolo organization: National Institute of Allergy and Infectious Diseases, NIH, MD, Bethesda, USA – sequence: 17 givenname: Peter G. surname: Medveczky fullname: Medveczky, Peter G. organization: Department of Molecular Medicine, University of South Florida, FL, Tampa, USA – sequence: 18 givenname: Jose G. surname: Montoya fullname: Montoya, Jose G. organization: Department of Infectious Disease, Stanford University, CA, Stanford, USA – sequence: 19 givenname: Yasuko surname: Mori fullname: Mori, Yasuko organization: Division of Clinical Virology, Kobe University, Hyōgo, Kobe, Japan – sequence: 20 givenname: Masao surname: Ogata fullname: Ogata, Masao organization: Hematology, Blood Transfusion Center, Oita University, Oita, Japan – sequence: 21 givenname: Joshua C. surname: Pritchett fullname: Pritchett, Joshua C. organization: HHV-6 Foundation, CA, Santa Barbara, USA – sequence: 22 givenname: Sylvie surname: Rogez fullname: Rogez, Sylvie organization: Department of Virology, CHRU Dupuytren, Limoges, France – sequence: 23 givenname: Edward surname: Seto fullname: Seto, Edward organization: Department of Molecular Oncology, Moffitt Cancer Center & Research Institute, USA – sequence: 24 givenname: Katherine N. surname: Ward fullname: Ward, Katherine N. organization: Department of Infection, University College London, London, UK – sequence: 25 givenname: Tetsushi surname: Yoshikawa fullname: Yoshikawa, Tetsushi organization: Department of Pediatrics, Fujita Health University, Aichi, Toyoake, Japan – sequence: 26 givenname: Raymund R. surname: Razonable fullname: Razonable, Raymund R. email: P. E. Pellett, PhD, Professor, Department of Immunology, and Microbiology, Wayne State University, 6225 Scott Hall, 540 East Canfield Avenue, Detroit, MI 48201. R. Razonable, MD, Associate Professor, Division of Infectious Diseases and Internal Medicine, Mayo Clinic, Rochester, MN 55905., ppellett@med.wayne.edurazonable.raymund@mayo.edu organization: Division of Infectious Diseases, Mayo Clinic, MN, Rochester, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22052666$$D View this record in MEDLINE/PubMed |
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Hammerling JA, Lambrecht RS, 2007; 104 2009; 46 1993; 67 1993; 329 2011; 117 2010; 107 2009; 81 2003; 17 2011; 18 2007; 79 1995; 171 2009; 159 2010; 20 2004; 73 2010; 29 2006; 27 1999; 59 2010; 157 1999; 57 2008; 359 2005; 76 2005; 32 2011; 26 2003; 82 2007; 22 2007; 68 2007; 69 2004; 145 2010; 31 2000; 69 2011 2005; 111 1995; 16 2010 2002; 34 2004; 140 2010; 201 1999; 24 2008; 15 2003; 36 2007 2007; 92 2002; 4 2006; 194 2006; 193 2008; 122 2006; 118 2003; 31 2010; 84 2006; 114 2001; 248 2010; 82 2002; 25 2007; 157 2010; 48 2002; 29 2009; 31 2006; 45 2004; 17 2006; 44 1995; 46 2011; 92 2011; 51 2008; 48 2009; 145 2009; 9 2007; 40 2008; 42 2008; 40 1996; 49 2007; 45 2005; 12 2008; 80 e_1_2_6_51_1 e_1_2_6_74_1 e_1_2_6_53_1 e_1_2_6_76_1 e_1_2_6_32_1 e_1_2_6_70_1 e_1_2_6_30_1 e_1_2_6_72_1 Pellett PE (e_1_2_6_6_1) 2011 e_1_2_6_19_1 Mardivirin L (e_1_2_6_52_1) 2010; 20 e_1_2_6_13_1 e_1_2_6_36_1 e_1_2_6_59_1 e_1_2_6_34_1 e_1_2_6_17_1 e_1_2_6_55_1 e_1_2_6_78_1 e_1_2_6_15_1 e_1_2_6_38_1 e_1_2_6_57_1 e_1_2_6_62_1 e_1_2_6_85_1 Yamanishi K (e_1_2_6_3_1) 2007 e_1_2_6_64_1 e_1_2_6_87_1 e_1_2_6_43_1 e_1_2_6_81_1 e_1_2_6_20_1 e_1_2_6_41_1 e_1_2_6_60_1 e_1_2_6_83_1 Delecluse HJ (e_1_2_6_50_1) 1993; 67 e_1_2_6_9_1 e_1_2_6_5_1 e_1_2_6_7_1 Yamashita N (e_1_2_6_8_1) 2005; 12 e_1_2_6_24_1 e_1_2_6_49_1 Clark DA (e_1_2_6_2_1) 2008; 15 e_1_2_6_22_1 e_1_2_6_66_1 e_1_2_6_28_1 e_1_2_6_45_1 e_1_2_6_26_1 e_1_2_6_47_1 e_1_2_6_68_1 e_1_2_6_73_1 e_1_2_6_54_1 e_1_2_6_75_1 e_1_2_6_10_1 e_1_2_6_31_1 e_1_2_6_71_1 e_1_2_6_14_1 e_1_2_6_35_1 e_1_2_6_12_1 e_1_2_6_33_1 e_1_2_6_18_1 e_1_2_6_39_1 e_1_2_6_56_1 e_1_2_6_77_1 e_1_2_6_16_1 e_1_2_6_37_1 e_1_2_6_58_1 e_1_2_6_79_1 e_1_2_6_63_1 e_1_2_6_84_1 e_1_2_6_42_1 e_1_2_6_65_1 e_1_2_6_86_1 e_1_2_6_21_1 e_1_2_6_80_1 e_1_2_6_40_1 e_1_2_6_61_1 e_1_2_6_82_1 e_1_2_6_4_1 e_1_2_6_25_1 e_1_2_6_48_1 e_1_2_6_23_1 Gorniak RJ (e_1_2_6_11_1) 2006; 27 e_1_2_6_29_1 e_1_2_6_44_1 e_1_2_6_67_1 e_1_2_6_88_1 e_1_2_6_27_1 e_1_2_6_46_1 e_1_2_6_69_1 20211581 - J Clin Virol. 2010 May;48(1):55-7 10868648 - Transplantation. 2000 Jun 15;69(11):2400-4 19519818 - Am J Transplant. 2009 Jul;9(7):1690-7 20844040 - J Virol. 2010 Dec;84(23):12100-9 19505844 - J Clin Virol. 2009 Sep;46(1):33-6 12817443 - Poult Sci. 2003 Jun;82(6):893-8 15170644 - J Med Virol. 2004 Jul;73(3):465-73 15722023 - J Clin Virol. 2005 Mar;32(3):183-93 15480369 - J Pediatr. 2004 Oct;145(4):472-7 8380099 - J Virol. 1993 Jan;67(1):82-92 8943744 - J Clin Pathol. 1996 Oct;49(10):802-4 18687640 - N Engl J Med. 2008 Aug 7;359(6):593-602 18422852 - Transfusion. 2008 Jun;48(6):1180-7 10022800 - J Med Virol. 1999 Mar;57(3):278-82 18428148 - J Med Virol. 2008 Jun;80(6):1051-7 15977239 - J Med Virol. 2005 Aug;76(4):563-70 21794043 - Transpl Infect Dis. 2012 Feb;14(1):33-9 19822481 - Eur J Dermatol. 2010 Jan-Feb;20(1):68-73 21565944 - Nephrol Dial Transplant. 2011 Jul;26(7):2391-3 11979309 - Bone Marrow Transplant. 2002 Apr;29(7):595-8 17229866 - J Clin Microbiol. 2007 Apr;45(4):1298-304 17678724 - Hum Immunol. 2007 Aug;68(8):685-9 7561787 - J Med Virol. 1995 Jul;46(3):178-88 16679694 - Intern Med. 2006;45(7):417-8 20872717 - J Med Virol. 2010 Nov;82(11):1903-10 15494709 - Mod Pathol. 2004 Nov;17(11):1427-33 17854362 - Br J Dermatol. 2007 Nov;157(5):934-40 11518006 - J Neurol. 2001 Jul;248(7):619-20 20212114 - Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5563-8 16597897 - J Clin Microbiol. 2006 Apr;44(4):1571-4 19100492 - Transplant Proc. 2008 Dec;40(10):3791-3 19107978 - J Med Virol. 2009 Feb;81(2):258-63 20400100 - J Pediatr. 2010 Sep;157(3):511 18762520 - Pediatrics. 2008 Sep;122(3):513-20 18587440 - Bone Marrow Transplant. 2008 Aug;42(4):227-40 20088693 - J Infect Dis. 2010 Feb 15;201(4):505-7 20407819 - Eur J Clin Microbiol Infect Dis. 2010 Jul;29(7):881-6 18712834 - J Med Virol. 2008 Oct;80(10):1804-7 19114298 - Brain Dev. 2009 Nov;31(10):731-8 21458587 - Microbes Infect. 2011 Aug;13(8-9):731-41 14967790 - Arch Dermatol. 2004 Feb;140(2):183-8 19490982 - J Virol Methods. 2009 Aug;159(2):291-4 12665843 - Bone Marrow Transplant. 2003 Mar;31(6):475-9 21518144 - Eur J Neurol. 2011 Aug;18(8):1027-35 17133548 - J Med Virol. 2007 Jan;79(1):45-51 21389320 - Blood. 2011 May 12;117(19):5243-9 20648610 - J Med Virol. 2010 Sep;82(9):1560-8 16611785 - AJNR Am J Neuroradiol. 2006 Apr;27(4):887-91 20070702 - Am J Transplant. 2009 Dec;9 Suppl 4:S97-100 20827763 - J Med Virol. 2010 Oct;82(10):1669-78 11774077 - Clin Infect Dis. 2002 Feb 1;34(3):309-17 21802354 - J Clin Virol. 2011 Oct;52(2):142-5 17015795 - Circulation. 2006 Oct 10;114(15):1581-90 10516706 - Bone Marrow Transplant. 1999 Oct;24(8):919-23 7844362 - J Infect Dis. 1995 Feb;171(2):273-80 8390614 - N Engl J Med. 1993 Jul 15;329(3):156-61 19856545 - Herpes. 2008 Nov;15(2):28-32 17360322 - Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5067-72 15699250 - Circulation. 2005 Feb 22;111(7):887-93 16209861 - Herpes. 2005 Oct;12(2):46-9 21629177 - Transplantation. 2011 Jul 27;92(2):224-9 19497784 - J Clin Virol. 2009 Sep;46(1):29-32 12491213 - Clin Infect Dis. 2003 Jan 1;36(1):120-3 16323134 - J Infect Dis. 2006 Jan 1;193(1):68-79 12123421 - Transpl Infect Dis. 2002 Mar;4(1):10-6 16217752 - Int J Cancer. 2006 Apr 1;118(7):1603-8 12361757 - J Clin Virol. 2002 Aug;25 Suppl 2:S57-61 10534732 - J Med Virol. 1999 Dec;59(4):496-501 19758840 - J Clin Virol. 2009 Nov;46(3):300-2 12868990 - Clin Transplant. 2003 Aug;17(4):338-46 16960792 - J Infect Dis. 2006 Oct 1;194(7):1020-1; 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Chromosomally integrated human herpesvirus 6 (ciHHV‐6) is a condition in which the complete HHV‐6 genome is integrated into the host germ line genome... Chromosomally integrated human herpesvirus 6 (ciHHV‐6) is a condition in which the complete HHV‐6 genome is integrated into the host germ line genome and is... Chromosomally integrated human herpesvirus 6 (ciHHV-6) is a condition in which the complete HHV-6 genome is integrated into the host germ line genome and is... SUMMARY Chromosomally integrated human herpesvirus 6 (ciHHV-6) is a condition in which the complete HHV-6 genome is integrated into the host germ line genome... |
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| SubjectTerms | Chromosomes, Human - virology Herpesvirus 6, Human - genetics Herpesvirus 6, Human - physiology Humans Reviews Roseolovirus Infections - genetics Roseolovirus Infections - virology Virus Integration |
| Title | Chromosomally integrated human herpesvirus 6: questions and answers |
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