Genomic characterization and phylogenetic analysis of SARS‐COV‐2 in Italy

This report describes the isolation, molecular characterization, and phylogenetic analysis of the first three complete genomes of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) isolated from three patients involved in the first outbreak of COVID‐19 in Lombardy, Italy. Early molecular e...

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Published inJournal of medical virology Vol. 92; no. 9; pp. 1637 - 1640
Main Authors Zehender, Gianguglielmo, Lai, Alessia, Bergna, Annalisa, Meroni, Luca, Riva, Agostino, Balotta, Claudia, Tarkowski, Maciej, Gabrieli, Arianna, Bernacchia, Dario, Rusconi, Stefano, Rizzardini, Giuliano, Antinori, Spinello, Galli, Massimo
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.09.2020
John Wiley and Sons Inc
Subjects
complete genomes of SARS‐CoV‐2
Computational Biology - methods
Coronaviruses
COVID-19
COVID-19 - epidemiology
COVID-19 - virology
Epidemiology
Genome, Viral
Genomes
Genomics - methods
Humans
Italy - epidemiology
phylogenetic analysis
Phylogenetics
Phylogeny
Regression Analysis
SARS-CoV-2 - classification
SARS-CoV-2 - genetics
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Short Communication
Short Communications
Viral diseases
Virology
Italy
COVID-19
complete genomes of SARS-CoV-2
phylogenetic analysis
Online AccessGet full text

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Abstract This report describes the isolation, molecular characterization, and phylogenetic analysis of the first three complete genomes of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) isolated from three patients involved in the first outbreak of COVID‐19 in Lombardy, Italy. Early molecular epidemiological tracing suggests that SARS‐CoV‐2 was present in Italy weeks before the first reported cases of infection.
AbstractList This report describes the isolation, molecular characterization, and phylogenetic analysis of the first three complete genomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) isolated from three patients involved in the first outbreak of COVID-19 in Lombardy, Italy. Early molecular epidemiological tracing suggests that SARS-CoV-2 was present in Italy weeks before the first reported cases of infection.
This report describes the isolation, molecular characterization, and phylogenetic analysis of the first three complete genomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) isolated from three patients involved in the first outbreak of COVID-19 in Lombardy, Italy. Early molecular epidemiological tracing suggests that SARS-CoV-2 was present in Italy weeks before the first reported cases of infection.This report describes the isolation, molecular characterization, and phylogenetic analysis of the first three complete genomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) isolated from three patients involved in the first outbreak of COVID-19 in Lombardy, Italy. Early molecular epidemiological tracing suggests that SARS-CoV-2 was present in Italy weeks before the first reported cases of infection.
Author Bergna, Annalisa
Tarkowski, Maciej
Rusconi, Stefano
Rizzardini, Giuliano
Antinori, Spinello
Gabrieli, Arianna
Riva, Agostino
Lai, Alessia
Galli, Massimo
Zehender, Gianguglielmo
Balotta, Claudia
Meroni, Luca
Bernacchia, Dario
AuthorAffiliation 3 Romeo ed Enrica Invernizzi Pediatric Research Center University of Milan Milan Italy
2 EpiSoMi CRC‐Coordinated Research Center University of Milan Milan Italy
1 Department of Biomedical and Clinical Sciences Luigi Sacco University of Milan Milan Italy
4 III Division of Infectious Diseases, ASST Fatebenefratelli Sacco Luigi Sacco Hospital Milan Italy
5 Department of Infectious Diseases Luigi Sacco Hospital Milan Italy
AuthorAffiliation_xml – name: 2 EpiSoMi CRC‐Coordinated Research Center University of Milan Milan Italy
– name: 4 III Division of Infectious Diseases, ASST Fatebenefratelli Sacco Luigi Sacco Hospital Milan Italy
– name: 5 Department of Infectious Diseases Luigi Sacco Hospital Milan Italy
– name: 1 Department of Biomedical and Clinical Sciences Luigi Sacco University of Milan Milan Italy
– name: 3 Romeo ed Enrica Invernizzi Pediatric Research Center University of Milan Milan Italy
Author_xml – sequence: 1
  givenname: Gianguglielmo
  orcidid: 0000-0002-1886-2915
  surname: Zehender
  fullname: Zehender, Gianguglielmo
  email: gianguglielmo.zehender@unimi.it
  organization: University of Milan
– sequence: 2
  givenname: Alessia
  orcidid: 0000-0002-3174-5721
  surname: Lai
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  surname: Rusconi
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  surname: Rizzardini
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– sequence: 13
  givenname: Massimo
  surname: Galli
  fullname: Galli, Massimo
  organization: Luigi Sacco Hospital
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Keywords COVID-19
complete genomes of SARS-CoV-2
phylogenetic analysis
Language English
License 2020 Wiley Periodicals, Inc.
This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.
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Notes Gianguglielmo Zehender and Alessia Lai contributed equally to this paper.
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– ident: e_1_2_9_13_1
– ident: e_1_2_9_9_1
  doi: 10.1093/molbev/mss084
– volume: 89
  start-page: 1
  year: 2020
  ident: e_1_2_9_12_1
  article-title: The proximal origin of SARS‐CoV‐2
  publication-title: Virological
– ident: e_1_2_9_5_1
  doi: 10.1093/bioinformatics/bts199
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Snippet This report describes the isolation, molecular characterization, and phylogenetic analysis of the first three complete genomes of severe acute respiratory...
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StartPage 1637
SubjectTerms complete genomes of SARS‐CoV‐2
Computational Biology - methods
Coronaviruses
COVID-19
COVID-19 - epidemiology
COVID-19 - virology
Epidemiology
Genome, Viral
Genomes
Genomics - methods
Humans
Italy - epidemiology
phylogenetic analysis
Phylogenetics
Phylogeny
Regression Analysis
SARS-CoV-2 - classification
SARS-CoV-2 - genetics
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Short Communication
Short Communications
Viral diseases
Virology
Title Genomic characterization and phylogenetic analysis of SARS‐COV‐2 in Italy
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjmv.25794
https://www.ncbi.nlm.nih.gov/pubmed/32222993
https://www.proquest.com/docview/2434422887
https://www.proquest.com/docview/2384494686
https://pubmed.ncbi.nlm.nih.gov/PMC7228393
Volume 92
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