Efficacy, Safety, and Pharmacokinetics of Candesartan Cilexetil in Hypertensive Children Aged 6 to 17 Years

• Published in: The journal of clinical hypertension (Greenwich, Conn.) Vol. 10; no. 10; pp. 743 - 750
• Main Authors: Trachtman, Howard, Hainer, James W., Sugg, Jennifer, Teng, Renli, Sorof, Jonathan M., Radcliffe, Jerilynn
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.10.2008
• Subjects: Adolescent; Antihypertensive Agents - administration & dosage; Antihypertensive Agents - adverse effects; Antihypertensive Agents - pharmacokinetics; Benzimidazoles - administration & dosage; Benzimidazoles - adverse effects; Benzimidazoles - pharmacokinetics; Biphenyl Compounds - administration & dosage; Biphenyl Compounds - adverse effects; Biphenyl Compounds - pharmacokinetics; Blood Pressure - drug effects; Child; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hypertension - drug therapy; Male; Original Papers; Tetrazoles - administration & dosage; Tetrazoles - adverse effects; Tetrazoles - pharmacokinetics; Treatment Outcome

This 4‐week randomized, double blind, placebo‐controlled study (N=240), 1‐year open label trial (N=233), and single‐dose pharmacokinetic study (N=22) evaluated candesartan cilexetil (3 doses) in hypertensive children aged 6 to 17 years. Seventy‐one percent were 12 years of age or older, 71% were mal...