Semagacestat pharmacokinetics are not significantly affected by formulation, food, or time of dosing in healthy participants - Willis, Brian A; Zhang, Wei; Ayan-Oshodi, Mosun; Lowe, Stephen L; Annes, William F; Sirois, Paul J; Friedrich, Stuart; de la Peña, Amparo (Journal of clinical pharmacology, 2012)
Keywords: Aged; Alanine - administration & dosage; Alanine - analogs & derivatives; Alanine - blood; Alanine - pharmacokinetics; Alanine - pharmacology; Amyloid beta-Peptides - blood; Amyloid Precursor Protein Secretases - antagonists & inhibitors; Azepines - administration & dosage; Azepines - blood; Azepines - pharmacokinetics; Azepines - pharmacology; Biological Availability; Capsules; Chemistry, Pharmaceutical; Cross-Over Studies; Drug Administration Schedule; Female; Food-Drug Interactions; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged; Nootropic Agents - administration & dosage; Nootropic Agents - blood; Nootropic Agents - pharmacokinetics; Nootropic Agents - pharmacology; Patient Dropouts; Peptide Fragments - blood; Tablets