Exploratory Study of Autoantibody Profiling in Drug‐Induced Liver Injury with an Autoimmune Phenotype

• Published in: Hepatology communications Vol. 4; no. 11; pp. 1651 - 1663
• Main Authors: Lammert, Craig, Zhu, Chengsong, Lian, Yun, Raman, Indu, Eckert, George, Li, Quan‐Zhen, Chalasani, Naga
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins 01.11.2020; John Wiley and Sons Inc; Wolters Kluwer Health/LWW
• Subjects: Antibiotics; Antibodies; Antigens; Biomarkers; Causality; Hepatitis; Immunoglobulins; Laboratories; Liver; Lupus; Neutrophils; Noise; Original; Phosphatase; Principal components analysis; Rheumatoid arthritis; Smooth muscle; Statistical analysis; Indiana; United States > US

Drug‐induced liver injury (DILI) sometimes presents with an autoimmune hepatitis‐like phenotype (AI‐DILI), and it is challenging to distinguish it from de novo autoimmune hepatitis (AIH). We conducted a study to identify autoantibodies unique to AI‐DILI by profiling serum autoantibodies. Autoantibod...