Nafamostat mesilate attenuates inflammation and apoptosis and promotes locomotor recovery after spinal cord injury

• Published in: CNS neuroscience & therapeutics Vol. 24; no. 5; pp. 429 - 438
• Main Authors: Duan, Hui‐Quan, Wu, Qiu‐Li, Yao, Xue, Fan, Bao‐You, Shi, Hong‐Yu, Zhao, Chen‐Xi, Zhang, Yan, Li, Bo, Sun, Chao, Kong, Xiao‐Hong, Zhou, Xin‐Fu, Feng, Shi‐Qing
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.05.2018; John Wiley and Sons Inc
• Subjects: Animal models; Animals; Annexin V; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Antibodies; Apoptosis; Apoptosis - drug effects; Apoptosis - physiology; Biotechnology; Brain-derived neurotrophic factor; Caspase; Contusions; Cytokines; Disease Models, Animal; Enzymes; Female; Guanidines - pharmacology; Inflammation; Inflammation - drug therapy; Inflammation - metabolism; Inflammation - pathology; Laboratory animals; Locomotion; Microenvironments; Motor Activity - drug effects; Motor Activity - physiology; nafamostat mesilate; Nerve growth factor; Nervous system; neuroinflammation; Neuroprotection; Neuroprotective Agents - pharmacology; Neurotrophic factors; Original; Pancreatitis; Proteinase inhibitors; Proteins; Random Allocation; Rats, Wistar; Recovery of Function - drug effects; Serine; Serine proteinase; Spinal Cord - drug effects; Spinal Cord - immunology; Spinal Cord - pathology; Spinal cord injuries; Spinal Cord Injuries - drug therapy; Spinal Cord Injuries - pathology; Spinal Cord Injuries - physiopathology; spinal cord injury; Substantia alba; Substantia grisea; Surgeons; Thrombin; Trauma; Tumor necrosis factor; Western blotting; Beijing China; United States > US; China; spinal cord injury; apoptosis; thrombin; nafamostat mesilate; neuroinflammation

Summary Aim Spinal cord injury (SCI) leads to severe neural damage for which there is currently no effective treatment. Exploration of the neuroprotective effect among clinically approved drugs will speed up clinical translation of SCI. Nafamostat mesilate (NM) as a synthetic serine protease inhibit...