Olfactory loss and brain connectivity after COVID‐19

• Published in: Human brain mapping Vol. 43; no. 5; pp. 1548 - 1560
• Main Authors: Esposito, Fabrizio, Cirillo, Mario, De Micco, Rosa, Caiazzo, Giuseppina, Siciliano, Mattia, Russo, Andrea Gerardo, Monari, Caterina, Coppola, Nicola, Tedeschi, Gioacchino, Tessitore, Alessandro
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.04.2022
• Subjects: Adult; Age; Angular resolution; anosmia; Anosmia - diagnostic imaging; Anosmia - etiology; Brain; Brain - diagnostic imaging; brain connectivity; Contraindications; Coronaviruses; Cortex (olfactory); Cortex (piriform); Cortex (somatosensory); COVID-19; COVID-19 - complications; COVID-19 - diagnostic imaging; Disease transmission; Female; Fibers; Functional magnetic resonance imaging; Humans; hyposmia; Impairment; Infections; Magnetic Resonance Imaging; Male; Males; Mental disorders; Nerve Net - diagnostic imaging; Neural networks; Olfaction disorders; Olfactory bulb; olfactory network; Olfactory system; Sensory neurons; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Smell - physiology; Structure-function relationships; Viral diseases; Viruses; COVID-19; brain connectivity; olfactory network; anosmia; hyposmia

To address the impact of COVID‐19 olfactory loss on the brain, we analyzed the neural connectivity of the central olfactory system in recently SARS‐CoV‐2 infected subjects with persisting olfactory impairment (hyposmia). Twenty‐seven previously SARS‐CoV‐2 infected subjects (10 males, mean age ± SD 4...