Studying the Interactions of U24 from HHV-6 in Order to Further Elucidate Its Potential Role in MS

• Published in: Viruses Vol. 14; no. 11; p. 2384
• Main Authors: Pi, Keng-Shuo, Bortolotti, Daria, Sang, Yurou, Schiuma, Giovanna, Beltrami, Silvia, Rizzo, Sabrina, Bortoluzzi, Alessandra, Baldi, Eleonora, Creagh, A Louise, Haynes, Charles A, Rizzo, Roberta, Straus, Suzana K
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.10.2022; MDPI
• Subjects: Calorimetry; Cell activation; Ethics; Fyn protein; Fyn-SH3; Genetic aspects; Health aspects; Herpesvirus 6, Human - physiology; human herpes virus; Human herpesvirus 6; Human subjects; Humans; Killer cells; Medical research; Membrane proteins; Multiple Sclerosis; Myelin; Myelin basic protein; Natural killer cells; Nedd4L; NMR; Nuclear magnetic resonance; Nuclear Magnetic Resonance, Biomolecular; Peptides; Phosphorylation; Physiological aspects; Potassium channels (inwardly-rectifying); Proteins; Risk factors; Roseolovirus; Roseolovirus Infections; Titration; Viral infections; Viruses; Canada; United States > US; Roseolovirus; natural killer cells; human herpes virus; multiple sclerosis; Nedd4L; Killer Cell Immunoglobulin Like Receptor 2DL2; phosphorylation; Fyn-SH3

A number of studies have suggested that human herpesvirus 6A (HHV-6A) may play a role in multiple sclerosis (MS). Three possible hypotheses have been investigated: (1) U24 from HHV-6A (U24-6A) mimics myelin basic protein (MBP) through analogous phosphorylation and interaction with Fyn-SH3; (2) U24-6...