A connexin43/YAP axis regulates astroglial-mesenchymal transition in hemoglobin induced astrocyte activation

• Published in: Cell death and differentiation Vol. 25; no. 10; pp. 1870 - 1884
• Main Authors: Yang, Yong, Ren, Jie, Sun, Yuhao, Xue, Yuan, Zhang, Zhijian, Gong, Aihua, Wang, Baofeng, Zhong, Zhihong, Cui, Zhenwen, Xi, Zhiyu, Yang, Guo-yuan, Sun, Qingfang, Bian, Liuguan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2018; Nature Publishing Group
• Subjects: 13/106; 13/109; 13/51; 13/89; 14/19; 38/77; 631/80/79/2028; 692/699/375; 82/1; 82/29; 82/80; Adaptor Proteins, Signal Transducing - chemistry; Adaptor Proteins, Signal Transducing - metabolism; Animals; Apoptosis; Astrocytes; Astrocytes - cytology; Astrocytes - drug effects; Astrocytes - metabolism; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Cycle Analysis; Cell Cycle Proteins; Cell Nucleus - metabolism; Cell Proliferation; Cells, Cultured; Central nervous system; Cerebral Hemorrhage - metabolism; Cerebral Hemorrhage - pathology; Connexin 43; Connexin 43 - antagonists & inhibitors; Connexin 43 - genetics; Connexin 43 - metabolism; Down-Regulation - drug effects; Epithelial-Mesenchymal Transition - drug effects; Glial fibrillary acidic protein; Glial Fibrillary Acidic Protein - metabolism; Gliosis; Hemoglobin; Hemoglobins - pharmacology; Hemorrhage; Immunofluorescence; Immunoprecipitation; Interleukin-1beta - genetics; Interleukin-1beta - metabolism; Life Sciences; Mesenchyme; Mice; Microscopy, Fluorescence; Nuclear transport; Phosphoproteins - chemistry; Phosphoproteins - metabolism; Protein Binding; Protein Transport - drug effects; RNA Interference; RNA, Small Interfering - metabolism; siRNA; Stem Cells; Therapeutic applications; Vimentin; Yes-associated protein

Reactive astrogliosis is a common response to insults to the central nervous system, but the mechanism remains unknown. In this study, we found the temporal and spatial differential expression of glial fibrillary acidic protein (GFAP) and Vimentin in the intracerebral hemorrhage (ICH) mouse brain, i...