Sestrin2 protects dendritic cells against endoplasmic reticulum stress-related apoptosis induced by high mobility group box-1 protein

• Published in: Cell death & disease Vol. 11; no. 2; p. 125
• Main Authors: Wang, Li-Xue, Zhu, Xiao-Mei, Luo, Yi-Nan, Wu, Yao, Dong, Ning, Tong, Ya-lin, Yao, Yong-Ming
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.02.2020; Springer Nature B.V
• Subjects: 13/95; 14/19; 38/109; 38/77; 631/250/1932; 631/80/82/23; 82; 82/1; 82/80; 96/2; 96/31; 96/35; Animals; Antibodies; Apoptosis; Apoptosis - drug effects; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Culture; Cell death; Cell Line; Dendritic cells; Dendritic Cells - drug effects; Dendritic Cells - immunology; Dendritic Cells - metabolism; Dendritic Cells - pathology; Disease Models, Animal; eIF-2 Kinase - metabolism; Endoplasmic reticulum; Endoplasmic Reticulum Stress - drug effects; Evolutionary conservation; High mobility group proteins; HMGB1 protein; HMGB1 Protein - pharmacology; Immune system; Immunology; Life Sciences; Male; Mice, Inbred C57BL; Mice, Knockout; Mobility; Peroxidases - deficiency; Peroxidases - genetics; Peroxidases - metabolism; Proteins; Sepsis - genetics; Sepsis - metabolism; Sepsis - microbiology; Sepsis - pathology; Signal Transduction; siRNA; Transcription Factor CHOP - metabolism
• ISSN: 2041-4889; 2041-4889
• DOI: 10.1038/s41419-020-2324-4

Sestrin2 (SESN2) is a highly evolutionary conserved protein and involved in different cellular responses to various stresses. However, the potential function of SESN2 in immune system remains unclear. The present study was designed to test whether dendritic cells (DCs) could express SESN2, and inves...