hiPSC-derived neural stem cells from patients with schizophrenia induce an impaired angiogenesis

• Published in: Translational psychiatry Vol. 8; no. 1; pp. 48 - 15
• Main Authors: Casas, Bárbara S., Vitória, Gabriela, do Costa, Marcelo N., Madeiro da Costa, Rodrigo, Trindade, Pablo, Maciel, Renata, Navarrete, Nelson, Rehen, Stevens K., Palma, Verónica
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.02.2018; Nature Publishing Group
• Subjects: 13/100; 13/106; 13/51; 14/19; 14/56; 14/63; 38/77; 631/378/340; 631/532; 692/699/476/1799; 82/79; 82/80; 96/1; Angiogenesis; Angiogenesis Inducing Agents - metabolism; Behavioral Sciences; Biological Psychology; Female; Humans; Induced Pluripotent Stem Cells - metabolism; Induced Pluripotent Stem Cells - physiology; Male; Medicine; Medicine & Public Health; Neovascularization, Pathologic - metabolism; Neovascularization, Pathologic - physiopathology; Neural Stem Cells - metabolism; Neural Stem Cells - physiology; Neurogenesis - physiology; Neurosciences; Pharmacotherapy; Psychiatry; Schizophrenia; Schizophrenia - metabolism; Schizophrenia - physiopathology; Stem cells

Schizophrenia is a neurodevelopmental disease characterized by cerebral connectivity impairment and loss of gray matter. It was described in adult schizophrenia patients (SZP) that concentration of VEGFA, a master angiogenic factor, is decreased. Recent evidence suggests cerebral hypoperfusion relat...