Bottom-up construction of in vitro switchable memories

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 109; no. 47; pp. E3212 - E3220
• Main Authors: Padirac, Adrien, Fujii, Teruo, Rondelez, Yannick
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 20.11.2012; National Acad Sciences
• Series: PNAS Plus
• Subjects: Biological Sciences; Cells; Deoxyribonucleic acid; DNA; DNA - genetics; DNA - metabolism; Epigenetics; Feedback, Physiological; Gene Regulatory Networks; Genes, Switch; Memory; Models, Genetic; PNAS Plus; synthetic biology; Templates, Genetic; topology

Reaction networks displaying bistability provide a chemical mechanism for long-term memory storage in cells, as exemplified by many epigenetic switches. These biological systems are not only bistable but switchable, in the sense that they can be flipped from one state to the other by application of...