The clinical application of metagenomic next-generation sequencing in immunocompromised patients with severe respiratory infections in the ICU

• Published in: Respiratory research Vol. 25; no. 1; pp. 360 - 13
• Main Authors: Zhao, Junjie, Sun, Yong, Tang, Jing, Guo, Kai, Wang, Kaiyu, Zhuge, Jiancheng, Fang, Honglong
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.10.2024; BioMed Central; BMC
• Subjects: Adult; Aged; Analysis; Anti-Bacterial Agents - therapeutic use; Antibiotics; Bronchoalveolar lavage fluid; Bronchoalveolar Lavage Fluid - microbiology; Care and treatment; Comparative analysis; Development and progression; DNA sequencing; Dosage and administration; Etiology; Female; Health aspects; High-Throughput Nucleotide Sequencing - methods; Hospital patients; Humans; Immunocompromised Host; Infection; Intensive Care Units; Lung diseases; Male; Medical research; Medicine, Experimental; Metagenomic next-generation sequencing; Metagenomics - methods; Microbiology; Middle Aged; Mortality; Nucleotide sequencing; Prognosis; Respiratory Tract Infections - diagnosis; Respiratory Tract Infections - drug therapy; Respiratory Tract Infections - immunology; Respiratory Tract Infections - microbiology; Respiratory Tract Infections - mortality; Retrospective Studies; Severe respiratory infections; Severity of Illness Index; China; Bronchoalveolar lavage fluid; Metagenomic next-generation sequencing; Antibiotics; Severe respiratory infections; Etiology

Early targeted antibiotic therapy is crucial for improving the prognosis of immunocompromised patients with severe respiratory infections (SRIs) in the intensive care unit (ICU). Metagenomic next-generation sequencing (mNGS) has shown significant value in pathogen detection, but research on lower re...