Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction

• Published in: Frontiers in cellular neuroscience Vol. 15; p. 661838
• Main Authors: Takata, Fuyuko, Nakagawa, Shinsuke, Matsumoto, Junichi, Dohgu, Shinya
• Format: Journal Article
• Language: English
• Published: Lausanne Frontiers Research Foundation 13.09.2021; Frontiers Media S.A
• Subjects: Alzheimer's disease; Amyotrophic lateral sclerosis; astrocyte; Astrocytes; Blood-brain barrier; Cell activation; Cytokines; Endothelial cells; Glial cells; Homeostasis; Inflammation; Intracellular signalling; Microglia; Microvasculature; Neurodegeneration; Neurodegenerative diseases; Neurological diseases; Neuronal-glial interactions; Neuroscience; Neurotoxicity; oligodendrocyte; Oligodendrocytes; Parenchyma; pericyte; Pericytes; Plasma proteins; Signal transduction; tight junction; Tight junctions; Traumatic brain injury

Neuroinflammation is involved in the onset or progression of various neurodegenerative diseases. Initiation of neuroinflammation is triggered by endogenous substances (damage-associated molecular patterns) and/or exogenous pathogens. Activation of glial cells (microglia and astrocytes) is widely rec...