CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: dietary modulation in the PREDIMED randomized trial

• Published in: Cardiovascular diabetology Vol. 15; no. 1; pp. 4 - 15
• Main Authors: Corella, Dolores, Asensio, Eva. M., Coltell, Oscar, Sorlí, José V., Estruch, Ramón, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Castañer, Olga, Arós, Fernando, Lapetra, José, Serra-Majem, Lluís, Gómez-Gracia, Enrique, Ortega-Azorín, Carolina, Fiol, Miquel, Espino, Javier Díez, Díaz-López, Andrés, Fitó, Montserrat, Ros, Emilio, Ordovás, José M.
• Format: Journal Article
• Language: English
• Published: England BioMed Central 07.01.2016
• Subjects: Aged; Aged, 80 and over; Cardiovascular diseases; Cardiovascular Diseases - diagnosis; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - genetics; Cardiovascular Diseases - physiopathology; Cardiovascular Diseases - prevention & control; Chi-Square Distribution; Circadian Rhythm - genetics; CLOCK Proteins - genetics; Cuina mediterrània; Diabetes; Diabetes Mellitus, Type 2 - diagnosis; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - physiopathology; Diabetes Mellitus, Type 2 - prevention & control; Diabetis; Diet, Mediterranean; Gene Frequency; Gene-Environment Interaction; Genetic Predisposition to Disease; Heterozygote; Homozygote; Humans; Incidence; Kaplan-Meier Estimate; Longitudinal Studies; Malalties cardiovasculars; Male; Mediterranean cooking; Middle Aged; Multivariate Analysis; Original Investigation; Phenotype; Polymorphism, Single Nucleotide; Proportional Hazards Models; Protective Factors; Risk Assessment; Risk Factors; Spain - epidemiology; Time Factors; Treatment Outcome

Circadian rhythms regulate key biological processes influencing metabolic pathways. Disregulation is associated with type 2 diabetes (T2D) and cardiovascular diseases (CVD). Circadian rhythms are generated by a transcriptional autoregulatory feedback loop involving core clock genes. CLOCK (circadian...