A single early-life seizure results in long-term behavioral changes in the adult Fmr1 knockout mouse

• Published in: Epilepsy research Vol. 157; p. 106193
• Main Authors: Hodges, Samantha L., Reynolds, Conner D., Nolan, Suzanne O., Huebschman, Jessica L., Okoh, James T., Binder, Matthew S., Lugo, Joaquin N.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2019
• Subjects: Animals; Autism; Autism Spectrum Disorder - complications; Autism Spectrum Disorder - genetics; Autism Spectrum Disorder - physiopathology; Behavior, Animal - physiology; Conditioning, Classical - physiology; Disease Models, Animal; Double-hit; Fragile X Mental Retardation Protein - genetics; Fragile X syndrome; Kainic Acid; Male; Mice; Mice, Knockout; Motor Activity - physiology; Prepulse inhibition; Repetitive behavior; Seizures; Seizures - chemically induced; Seizures - complications; Seizures - physiopathology; Social Behavior; Status Epilepticus - chemically induced; Status Epilepticus - complications; Status Epilepticus - physiopathology; Autism; Fragile X syndrome; Double-hit; Repetitive behavior; Seizures; Prepulse inhibition

•Early-life seizures increased repetitive behavior in adult wild type (WT) mice.•Repetitive behavior in Fmr1 knockout mice was not exacerbated following seizures.•Deletion of Fmr1 and seizures had opposite effects on prepulse inhibition.•Early-life seizures resulted in reduced sociability in adult W...