Renal clearable catalytic gold nanoclusters for in vivo disease monitoring

• Published in: Nature nanotechnology Vol. 14; no. 9; pp. 883 - 890
• Main Authors: Loynachan, Colleen N., Soleimany, Ava P., Dudani, Jaideep S., Lin, Yiyang, Najer, Adrian, Bekdemir, Ahmet, Chen, Qu, Bhatia, Sangeeta N., Stevens, Molly M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2019; Nature Publishing Group
• Subjects: 631/61/350/354; 639/301/54; 639/925/352/1060; 639/925/352/2733; Animals; Biocompatibility; Catalysis; Catalytic activity; Chemistry and Materials Science; Colorectal Neoplasms - urine; Colorimetry; Colorimetry - methods; Disease; Disease detection; Excretion; Female; Gold; Gold - metabolism; Kidney - metabolism; Kidneys; Materials Science; Metal Nanoparticles - ultrastructure; Mice; Microenvironments; Mimicry; Nanoclusters; Nanotechnology; Nanotechnology and Microengineering; Peptides - metabolism; Peroxidase; Peroxidase - metabolism; Renal function; Toxicity; Tumors; Urinalysis - methods; Urine

Ultrasmall gold nanoclusters (AuNCs) have emerged as agile probes for in vivo imaging, as they exhibit exceptional tumour accumulation and efficient renal clearance properties. However, their intrinsic catalytic activity, which can enable an increased detection sensitivity, has yet to be explored fo...