Gut microbiome structure and metabolic activity in inflammatory bowel disease

• Published in: Nature microbiology Vol. 4; no. 2; pp. 293 - 305
• Main Authors: Franzosa, Eric A., Sirota-Madi, Alexandra, Avila-Pacheco, Julian, Fornelos, Nadine, Haiser, Henry J., Reinker, Stefan, Vatanen, Tommi, Hall, A. Brantley, Mallick, Himel, McIver, Lauren J., Sauk, Jenny S., Wilson, Robin G., Stevens, Betsy W., Scott, Justin M., Pierce, Kerry, Deik, Amy A., Bullock, Kevin, Imhann, Floris, Porter, Jeffrey A., Zhernakova, Alexandra, Fu, Jingyuan, Weersma, Rinse K., Wijmenga, Cisca, Clish, Clary B., Vlamakis, Hera, Huttenhower, Curtis, Xavier, Ramnik J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2019; Nature Publishing Group
• Subjects: 631/326/2565/2134; 631/326/2565/2142; 631/61/320; 692/699/1503/257; Bile acids; Biodiversity; Biomarkers - metabolism; Biomedical and Life Sciences; Colitis, Ulcerative - immunology; Colitis, Ulcerative - metabolism; Colitis, Ulcerative - microbiology; Crohn Disease - immunology; Crohn Disease - metabolism; Crohn Disease - microbiology; Digestive system; Feces - chemistry; Feces - microbiology; Gastrointestinal Microbiome - genetics; Gastrointestinal Microbiome - immunology; Gastrointestinal tract; Humans; Infectious Diseases; Inflammation - metabolism; Inflammation - microbiology; Inflammatory bowel disease; Inflammatory bowel diseases; Inflammatory Bowel Diseases - immunology; Inflammatory Bowel Diseases - metabolism; Inflammatory Bowel Diseases - microbiology; Intestinal microflora; Intestine; Leukocyte L1 Antigen Complex - analysis; Life Sciences; Medical Microbiology; Metabolites; Metabolome; Metabolomics; Metagenome; Microbiology; Microbiomes; Microbiota; Oxidative stress; Parasitology; Sphingolipids; Tetrapyrroles; Therapeutic applications; Ulcerative colitis; Virology

The inflammatory bowel diseases (IBDs), which include Crohn’s disease (CD) and ulcerative colitis (UC), are multifactorial chronic conditions of the gastrointestinal tract. While IBD has been associated with dramatic changes in the gut microbiota, changes in the gut metabolome—the molecular interfac...