Absorption of zinc and retention of calcium: Dose-dependent inhibition by phytate

• Published in: Journal of trace elements in medicine and biology Vol. 20; no. 1; pp. 49 - 57
• Main Authors: Fredlund, Kerstin, Isaksson, Mats, Rossander-Hulthén, Lena, Almgren, Annette, Sandberg, Ann-Sofie
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.01.2006
• Subjects: Absorption - drug effects; Administration, Oral; Adult; Calcium - antagonists & inhibitors; Calcium - metabolism; Calcium Radioisotopes; Calcium retention; Dose-Response Relationship, Drug; Female; Food Science; Food, Formulated; Humans; Inositol Phosphates - analysis; InsP 6; Livsmedelsvetenskap; Male; Medical and Health Sciences; Medicin och hälsovetenskap; Middle Aged; Phytate; Phytic Acid - administration & dosage; Phytic Acid - pharmacology; Proteins - analysis; Reference Values; Whole-body counting; Zinc - antagonists & inhibitors; Zinc - metabolism; Zinc absorption; Zinc Radioisotopes; Zinc absorption; InsP 6; Whole-body counting; Phytate; Calcium retention

The dose-dependent inhibitory effect of sodium phytate ( myo-inositol-hexaphosphate) on absorption of zinc and retention of calcium was studied in man. No systematic study of this dose–response effect has been reported to this time. Forty subjects were served meals containing white wheat rolls witho...