Inhibition of inflammatory microglia by dietary fiber and short-chain fatty acids

• Published in: Scientific reports Vol. 13; no. 1; p. 2819
• Main Authors: Caetano-Silva, Maria Elisa, Rund, Laurie, Hutchinson, Noah T., Woods, Jeffrey A., Steelman, Andrew J., Johnson, Rodney W.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.02.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/256/2515; 631/250/371; 631/337/176; Acetic acid; Animals; Anti-Inflammatory Agents; Cecum; Dietary fiber; Dietary Fiber - pharmacology; Digestive system; Epigenetics; Fatty acids; Fatty Acids, Volatile - metabolism; Gastrointestinal tract; Histone deacetylase; Homeostasis; Humanities and Social Sciences; Inflammation; Intestinal microflora; Intestine; Inulin; Inulin - metabolism; Inulin - pharmacology; Lipopolysaccharides; Lipopolysaccharides - pharmacology; Membrane Transport Proteins; Mice; Microbiota; Microglia; Microglia - metabolism; multidisciplinary; Nuclear transport; Portal vein; Science; Science (multidisciplinary); Sequence analysis; Translocation; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Tumor necrosis factor-α

Microglia play a vital role maintaining brain homeostasis but can also cause persistent neuroinflammation. Short-chain fatty acids (SCFAs) produced by the intestinal microbiota have been suggested to regulate microglia inflammation indirectly by signaling through the gut-brain axis or directly by re...