Clinical relevance of TP53 hotspot mutations in high-grade serous ovarian cancers

• Published in: British journal of cancer Vol. 122; no. 3; pp. 405 - 412
• Main Authors: Tuna, Musaffe, Ju, Zhenlin, Yoshihara, Kosuke, Amos, Christopher I., Tanyi, Janos L., Mills, Gordon B.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.02.2020; Nature Publishing Group
• Subjects: 631/67/1517/1709; 692/53/2422; Biomedical and Life Sciences; Biomedicine; Cancer Research; Carcinoma, Ovarian Epithelial - genetics; Carcinoma, Ovarian Epithelial - metabolism; Carcinoma, Ovarian Epithelial - pathology; Clinical outcomes; Disease-Free Survival; Drug Resistance; Epidemiology; Female; Gain of Function Mutation; Humans; Loss of Function Mutation; Middle Aged; Missense mutation; Molecular Medicine; Mutation; Mutation hot spots; Neoplasm Grading; Neoplasm Staging; Oncology; Ovarian cancer; Ovarian Neoplasms - genetics; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; p53 Protein; Population studies; Prognosis; Proportional Hazards Models; Survival; Survival Rate; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism
• ISSN: 0007-0920; 1532-1827; 1532-1827
• DOI: 10.1038/s41416-019-0654-8

Background Mutation of TP53 is the most frequent genetic alteration in high-grade serous ovarian cancer (HGSOC). The impact of hotspot mutations of TP53 and protein levels on patient outcomes in HGSOC has not been fully elucidated. Methods The study population ( n  = 791) comprised of HGSOC samples...