C/EBPα in normal and malignant myelopoiesis

• Published in: International journal of hematology Vol. 101; no. 4; pp. 330 - 341
• Main Author: Friedman, Alan D.
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.04.2015
• Subjects: Animals; CCAAT-Enhancer-Binding Protein-alpha - analysis; CCAAT-Enhancer-Binding Protein-alpha - genetics; CCAAT-Enhancer-Binding Protein-alpha - metabolism; CCAAT-Enhancer-Binding Proteins - genetics; CCAAT-Enhancer-Binding Proteins - metabolism; Core Binding Factor Alpha 2 Subunit - genetics; Core Binding Factor Alpha 2 Subunit - metabolism; Gene Expression Regulation, Developmental; Gene Expression Regulation, Leukemic; Hematology; Humans; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - metabolism; Leukemia, Myeloid, Acute - pathology; Medicine; Medicine & Public Health; MicroRNAs - genetics; MicroRNAs - metabolism; Mutation; Myelopoiesis; Oncology; Progress in Hematology; Protein Processing, Post-Translational; C/EBPα; Myeloid; Differentiation; Acute myeloid leukemia (AML)

CCAAT/enhancer binding protein α (C/EBPα) dimerizes via its leucine zipper (LZ) domain to bind DNA via its basic region and activate transcription via N-terminal trans-activation domains. The activity of C/EBPα is modulated by several serine/threonine kinases and via sumoylation, its gene is activat...