Accelerated epigenetic aging and mitochondrial DNA copy number in bipolar disorder

• Published in: Translational psychiatry Vol. 7; no. 12; pp. 1283 - 10
• Main Authors: Fries, Gabriel R., Bauer, Isabelle E., Scaini, Giselli, Wu, Mon-Ju, Kazimi, Iram F., Valvassori, Samira S., Zunta-Soares, Giovana, Walss-Bass, Consuelo, Soares, Jair C., Quevedo, Joao
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.12.2017; Nature Publishing Group
• Subjects: 631/208/212/2166; 692/699/476/1333; Adult; Age; Aging; Behavioral Sciences; Biological clocks; Biological Psychology; Bipolar disorder; Bipolar Disorder - genetics; Cerebellum - metabolism; DNA Copy Number Variations; DNA Methylation; DNA, Mitochondrial - genetics; Epigenesis, Genetic; Female; Humans; Male; Medicine; Medicine & Public Health; Mitochondrial DNA; Neurosciences; Pharmacotherapy; Psychiatry; Telomere - metabolism

Bipolar disorder (BD) has been previously associated with accelerated aging; yet, the mechanisms underlying this association are largely unknown. The epigenetic clock has been increasingly recognized as a valuable aging marker, although its association with other biological clocks in BD patients and...