Effects of cardioactive drugs on human induced pluripotent stem cell derived long QT syndrome cardiomyocytes

• Published in: SpringerPlus Vol. 5; no. 1; p. 234
• Main Authors: Kuusela, Jukka, Kujala, Ville J., Kiviaho, Anna, Ojala, Marisa, Swan, Heikki, Kontula, Kimmo, Aalto-Setälä, Katriina
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 29.02.2016; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Humanities and Social Sciences; multidisciplinary; Science; Science (multidisciplinary); Side effects; Stem cells; Multielectrode array; Patient-specific; Arrhythmia; Induced pluripotent stem cell; Long QT syndrome; Cardiomyocytes; Cardioactive drug

Human induced pluripotent stem cells (hiPSC) have enabled a major step forward in pathophysiologic studies of inherited diseases and may also prove to be valuable in in vitro drug testing. Long QT syndrome (LQTS), characterized by prolonged cardiac repolarization and risk of sudden death, may be inh...