Borderline Resectable Pancreatic Cancer: The Importance of This Emerging Stage of Disease
Background Patients with borderline resectable pancreatic adenocarcinoma (PA) include those with localized disease who have tumor or patient characteristics that preclude immediate surgery. There is no optimal treatment schema for this distinct stage of disease, so the role of surgery is undefined....
Saved in:
| Published in | Journal of the American College of Surgeons Vol. 206; no. 5; pp. 833 - 846 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.05.2008
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Background Patients with borderline resectable pancreatic adenocarcinoma (PA) include those with localized disease who have tumor or patient characteristics that preclude immediate surgery. There is no optimal treatment schema for this distinct stage of disease, so the role of surgery is undefined. Study Design We defined patients with borderline resectable PA as fitting into one of three distinct groups. Group A comprised patients with tumor abutment of the visceral arteries or short-segment occlusion of the Superior Mesenteric Vein. In group B, patients had findings suggestive but not diagnostic of metastasis. Group C patients were of marginal performance status. Patients were treated initially with chemotherapy, chemoradiation, or both; those of sufficient performance status who completed preoperative therapy without disease progression were considered for surgery. Results Between October 1999 and August 2006, 160 (7%) of 2,454 patients with PA were classified as borderline resectable. Of these, 125 (78%) completed preoperative therapy and restaging, and 66 (41%) underwent pancreatectomy. Vascular resection was required in 18 (27%) of 66 patients, and 62 (94%) underwent a margin-negative pancreatectomy. A partial pathologic response to induction therapy (< 50% viable tumor) was seen in 37 (56%) of 66 patients. Median survival was 40 months for the 66 patients who completed all therapy and 13 months for the 94 patients who did not undergo pancreatectomy (p < 0.001). Conclusions This is the first large report of borderline resectable PA and includes objective definitions for this stage of disease. Our neoadjuvant approach allowed for identification of the marked subset of patients that was most likely to benefit from surgery, as evidenced by the favorable median survival in this group. |
|---|---|
| AbstractList | Background Patients with borderline resectable pancreatic adenocarcinoma (PA) include those with localized disease who have tumor or patient characteristics that preclude immediate surgery. There is no optimal treatment schema for this distinct stage of disease, so the role of surgery is undefined. Study Design We defined patients with borderline resectable PA as fitting into one of three distinct groups. Group A comprised patients with tumor abutment of the visceral arteries or short-segment occlusion of the Superior Mesenteric Vein. In group B, patients had findings suggestive but not diagnostic of metastasis. Group C patients were of marginal performance status. Patients were treated initially with chemotherapy, chemoradiation, or both; those of sufficient performance status who completed preoperative therapy without disease progression were considered for surgery. Results Between October 1999 and August 2006, 160 (7%) of 2,454 patients with PA were classified as borderline resectable. Of these, 125 (78%) completed preoperative therapy and restaging, and 66 (41%) underwent pancreatectomy. Vascular resection was required in 18 (27%) of 66 patients, and 62 (94%) underwent a margin-negative pancreatectomy. A partial pathologic response to induction therapy (< 50% viable tumor) was seen in 37 (56%) of 66 patients. Median survival was 40 months for the 66 patients who completed all therapy and 13 months for the 94 patients who did not undergo pancreatectomy (p < 0.001). Conclusions This is the first large report of borderline resectable PA and includes objective definitions for this stage of disease. Our neoadjuvant approach allowed for identification of the marked subset of patients that was most likely to benefit from surgery, as evidenced by the favorable median survival in this group. Patients with borderline resectable pancreatic adenocarcinoma (PA) include those with localized disease who have tumor or patient characteristics that preclude immediate surgery. There is no optimal treatment schema for this distinct stage of disease, so the role of surgery is undefined. We defined patients with borderline resectable PA as fitting into one of three distinct groups. Group A comprised patients with tumor abutment of the visceral arteries or short-segment occlusion of the Superior Mesenteric Vein. In group B, patients had findings suggestive but not diagnostic of metastasis. Group C patients were of marginal performance status. Patients were treated initially with chemotherapy, chemoradiation, or both; those of sufficient performance status who completed preoperative therapy without disease progression were considered for surgery. Between October 1999 and August 2006, 160 (7%) of 2,454 patients with PA were classified as borderline resectable. Of these, 125 (78%) completed preoperative therapy and restaging, and 66 (41%) underwent pancreatectomy. Vascular resection was required in 18 (27%) of 66 patients, and 62 (94%) underwent a margin-negative pancreatectomy. A partial pathologic response to induction therapy (< 50% viable tumor) was seen in 37 (56%) of 66 patients. Median survival was 40 months for the 66 patients who completed all therapy and 13 months for the 94 patients who did not undergo pancreatectomy (p < 0.001). This is the first large report of borderline resectable PA and includes objective definitions for this stage of disease. Our neoadjuvant approach allowed for identification of the marked subset of patients that was most likely to benefit from surgery, as evidenced by the favorable median survival in this group. BACKGROUNDPatients with borderline resectable pancreatic adenocarcinoma (PA) include those with localized disease who have tumor or patient characteristics that preclude immediate surgery. There is no optimal treatment schema for this distinct stage of disease, so the role of surgery is undefined.STUDY DESIGNWe defined patients with borderline resectable PA as fitting into one of three distinct groups. Group A comprised patients with tumor abutment of the visceral arteries or short-segment occlusion of the Superior Mesenteric Vein. In group B, patients had findings suggestive but not diagnostic of metastasis. Group C patients were of marginal performance status. Patients were treated initially with chemotherapy, chemoradiation, or both; those of sufficient performance status who completed preoperative therapy without disease progression were considered for surgery.RESULTSBetween October 1999 and August 2006, 160 (7%) of 2,454 patients with PA were classified as borderline resectable. Of these, 125 (78%) completed preoperative therapy and restaging, and 66 (41%) underwent pancreatectomy. Vascular resection was required in 18 (27%) of 66 patients, and 62 (94%) underwent a margin-negative pancreatectomy. A partial pathologic response to induction therapy (< 50% viable tumor) was seen in 37 (56%) of 66 patients. Median survival was 40 months for the 66 patients who completed all therapy and 13 months for the 94 patients who did not undergo pancreatectomy (p < 0.001).CONCLUSIONSThis is the first large report of borderline resectable PA and includes objective definitions for this stage of disease. Our neoadjuvant approach allowed for identification of the marked subset of patients that was most likely to benefit from surgery, as evidenced by the favorable median survival in this group. |
| Author | Evans, Douglas B., MD, FACS Pisters, Peter W.T., MD, FACS Wolff, Robert A., MD Lee, Jeffrey E., MD, FACS Crane, Christopher H., MD Fleming, Jason B., MD, FACS Varadhachary, Gauri R., MD Hwang, Rosa F., MD Abdalla, Eddie K., MD, FACS Katz, Matthew H.G., MD Vauthey, J. Nicolas, MD, FACS Sun, Charlotte C., DrPH, MPH |
| AuthorAffiliation | 2 Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 3 Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 1 Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 4 Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 |
| AuthorAffiliation_xml | – name: 1 Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 – name: 2 Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 – name: 3 Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 – name: 4 Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030 |
| Author_xml | – sequence: 1 fullname: Katz, Matthew H.G., MD – sequence: 2 fullname: Pisters, Peter W.T., MD, FACS – sequence: 3 fullname: Evans, Douglas B., MD, FACS – sequence: 4 fullname: Sun, Charlotte C., DrPH, MPH – sequence: 5 fullname: Lee, Jeffrey E., MD, FACS – sequence: 6 fullname: Fleming, Jason B., MD, FACS – sequence: 7 fullname: Vauthey, J. Nicolas, MD, FACS – sequence: 8 fullname: Abdalla, Eddie K., MD, FACS – sequence: 9 fullname: Crane, Christopher H., MD – sequence: 10 fullname: Wolff, Robert A., MD – sequence: 11 fullname: Varadhachary, Gauri R., MD – sequence: 12 fullname: Hwang, Rosa F., MD |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/18471707$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkk1v1DAQhi3Uin7AX0Dhwi1hxknWaw6VYClQqRKIlgMny3EmqUMSL3ZSqf8ep7uCllNPHo3feWc0z5ywg9GNxNhrhAwBV2-7rNODcX0fZt9mHEBkyDPg8Iwd41rIFFHCQYxB8FSUWB6xkxA6ABQgV8_ZEa4LEWNxzH5-cL4m39uRku8UyEy66in5pkfjSU_WJJsYkn-XXN9QcjFsnZ-WROKamLEhOR_It3Zsk6tJt_fpjzaQDvSCHTa6D_Ry_56yH5_Orzdf0suvny827y9TU-arKSUONWhJhhujNUDTFAXoqiik4VyWRhA0VcFLbETV1MJgVdYkc65LlHVVQH7Kzna-27kaqDY0Tl73auvtoP2dctqqxz-jvVGtu1WljPso8mjwZm_g3e-ZwqQGGwz1vR7JzUGtJIcSc4xCuRMa70Lw1PxtgqAWMKpTD8CoBYxCriKYWPvq4ZT_KvckomCzE1Dc1a0lr4KxFDddWx-pqNrZJ7U5-8_FRLTW6P4X3VHo3OzHCEOhCrFAXS0XshwICEC5xjz_AxpfvgA |
| CitedBy_id | crossref_primary_10_1245_s10434_011_1898_6 crossref_primary_10_1111_hpb_12015 crossref_primary_10_1200_JCO_2007_15_8642 crossref_primary_10_1016_j_pathol_2020_07_001 crossref_primary_10_1017_S1462399409001240 crossref_primary_10_20344_amp_19957 crossref_primary_10_1016_j_cireng_2017_10_005 crossref_primary_10_1007_s00534_011_0371_z crossref_primary_10_1016_j_pan_2014_09_006 crossref_primary_10_1093_annonc_mdu163 crossref_primary_10_1111_ans_18522 crossref_primary_10_1016_j_ciresp_2017_07_008 crossref_primary_10_1007_s12094_016_1586_x crossref_primary_10_1016_j_ejso_2010_08_132 crossref_primary_10_3389_fonc_2020_00516 crossref_primary_10_1111_j_1477_2574_2009_00145_x crossref_primary_10_1186_s12885_019_6148_5 crossref_primary_10_1002_jmri_21889 crossref_primary_10_1016_j_suronc_2021_101673 crossref_primary_10_1186_s12876_021_01955_7 crossref_primary_10_1016_j_surg_2012_07_036 crossref_primary_10_1186_s12957_017_1240_2 crossref_primary_10_1007_s11605_011_1811_4 crossref_primary_10_1016_j_adro_2022_101045 crossref_primary_10_1016_j_ejso_2016_05_023 crossref_primary_10_1016_j_yasu_2009_02_003 crossref_primary_10_1097_MPA_0000000000000634 crossref_primary_10_1097_MPA_0000000000001602 crossref_primary_10_1200_JCO_23_02494 crossref_primary_10_1016_j_lpm_2019_02_026 crossref_primary_10_1016_j_ijrobp_2011_08_008 crossref_primary_10_1016_j_pan_2015_11_007 crossref_primary_10_3390_cancers13081971 crossref_primary_10_1634_theoncologist_2019_0878 crossref_primary_10_1097_COC_0000000000000518 crossref_primary_10_1007_s10620_012_2482_z crossref_primary_10_1002_jso_26384 crossref_primary_10_1245_s10434_021_10560_7 crossref_primary_10_23736_S0026_4733_19_07958_6 crossref_primary_10_3390_ijms20112766 crossref_primary_10_1002_ags3_12494 crossref_primary_10_1007_s13193_014_0371_y crossref_primary_10_1016_j_pan_2018_01_004 crossref_primary_10_1089_pancan_2019_0013 crossref_primary_10_1007_s00534_013_0595_1 crossref_primary_10_1053_j_ro_2016_02_002 crossref_primary_10_1016_j_hoc_2022_06_002 crossref_primary_10_1245_s10434_021_09811_4 crossref_primary_10_1001_jamasurg_2020_2286 crossref_primary_10_1016_j_surg_2014_02_001 crossref_primary_10_1016_j_canlet_2016_02_039 crossref_primary_10_4103_ejs_ejs_92_23 crossref_primary_10_1186_s12885_016_2765_4 crossref_primary_10_1097_MD_0000000000032126 crossref_primary_10_1007_s13566_013_0115_6 crossref_primary_10_1155_2012_538769 crossref_primary_10_1002_jso_25067 crossref_primary_10_1002_jso_25183 crossref_primary_10_1002_jso_26394 crossref_primary_10_1007_s11864_013_0244_6 crossref_primary_10_1016_S1499_3872_11_60021_0 crossref_primary_10_3348_kjr_2021_0483 crossref_primary_10_1097_SLA_0000000000006248 crossref_primary_10_5009_gnl13264 crossref_primary_10_1007_s11605_022_05534_3 crossref_primary_10_1016_j_surg_2016_06_010 crossref_primary_10_1007_s00330_018_5410_6 crossref_primary_10_1097_MPA_0000000000000731 crossref_primary_10_1245_s10434_015_4854_z crossref_primary_10_1186_s13063_016_1262_z crossref_primary_10_5858_arpa_2011_0144_RA crossref_primary_10_1016_S0140_6736_10_62307_0 crossref_primary_10_1007_s00423_016_1488_y crossref_primary_10_1016_j_currproblcancer_2017_10_006 crossref_primary_10_1245_s10434_010_1019_y crossref_primary_10_1001_jamasurg_2019_2277 crossref_primary_10_1371_journal_pone_0090400 crossref_primary_10_1016_j_suc_2016_07_008 crossref_primary_10_1186_s13063_024_08196_5 crossref_primary_10_1016_j_suc_2016_07_005 crossref_primary_10_1016_j_surg_2017_09_012 crossref_primary_10_2958_suizo_36_73 crossref_primary_10_1016_j_soc_2023_02_001 crossref_primary_10_1097_MD_0000000000018151 crossref_primary_10_1093_jnci_djac018 crossref_primary_10_1016_j_surg_2020_08_002 crossref_primary_10_1007_s00268_016_3670_3 crossref_primary_10_1016_j_ciresp_2015_04_001 crossref_primary_10_1093_jjco_hyx191 crossref_primary_10_3390_jcm11164866 crossref_primary_10_1016_j_rcl_2010_02_021 crossref_primary_10_1177_1073274817729076 crossref_primary_10_1245_s10434_020_08789_9 crossref_primary_10_1007_s11605_018_3966_8 crossref_primary_10_1002_cncr_25763 crossref_primary_10_1016_j_ctro_2020_12_003 crossref_primary_10_1016_j_radonc_2020_11_007 crossref_primary_10_1097_COC_0000000000000601 crossref_primary_10_1007_s00104_011_2096_6 crossref_primary_10_1016_j_ultsonch_2015_05_029 crossref_primary_10_1245_s10434_011_2086_4 crossref_primary_10_2217_fon_2017_0050 crossref_primary_10_1245_s10434_022_13043_5 crossref_primary_10_4174_astr_2017_93_4_186 crossref_primary_10_1007_s00268_012_1622_0 crossref_primary_10_1016_j_canlet_2015_01_023 crossref_primary_10_1245_s10434_010_1456_7 crossref_primary_10_1111_hpb_12154 crossref_primary_10_1111_j_1477_2574_2009_00110_x crossref_primary_10_1007_s11605_011_1748_7 crossref_primary_10_1016_j_ijrobp_2019_08_057 crossref_primary_10_1016_j_yasu_2016_03_010 crossref_primary_10_3748_wjg_v20_i31_10740 crossref_primary_10_1002_cam4_4144 crossref_primary_10_1007_s00423_017_1578_5 crossref_primary_10_1016_j_suc_2013_02_005 crossref_primary_10_1016_j_surg_2012_05_029 crossref_primary_10_1007_s00268_018_04883_y crossref_primary_10_1186_s12885_020_07698_0 crossref_primary_10_1586_17474124_2015_1012496 crossref_primary_10_1016_j_semradonc_2016_05_002 crossref_primary_10_3389_fonc_2022_945829 crossref_primary_10_1002_jhbp_198 crossref_primary_10_1007_s11605_013_2181_x crossref_primary_10_1097_COC_0000000000000947 crossref_primary_10_1016_j_ctrv_2018_06_006 crossref_primary_10_3748_wjg_v23_i21_3765 crossref_primary_10_1002_jhbp_1302 crossref_primary_10_1016_j_suc_2017_09_006 crossref_primary_10_1016_j_suc_2017_09_009 crossref_primary_10_1053_j_ro_2013_03_005 crossref_primary_10_1634_theoncologist_2013_0273 crossref_primary_10_1016_j_pan_2019_12_006 crossref_primary_10_3892_ol_2017_6026 crossref_primary_10_1016_S1499_3872_14_60011_4 crossref_primary_10_1016_j_ijrobp_2019_07_004 crossref_primary_10_3390_cancers16030489 crossref_primary_10_1007_s11912_018_0685_y crossref_primary_10_1002_cncr_34273 crossref_primary_10_3390_ijms21228502 crossref_primary_10_1007_s12094_012_0962_4 crossref_primary_10_1002_14651858_CD014618 crossref_primary_10_29337_ijsp_142 crossref_primary_10_2214_AJR_08_1022 crossref_primary_10_1016_S1470_2045_15_00463_5 crossref_primary_10_1016_j_hpb_2023_07_883 crossref_primary_10_1245_s10434_014_4192_6 crossref_primary_10_1245_s10434_018_07131_8 crossref_primary_10_1007_s12262_015_1368_7 crossref_primary_10_1016_j_jss_2011_08_022 crossref_primary_10_1016_j_cireng_2015_04_006 crossref_primary_10_1016_j_suronc_2013_02_007 crossref_primary_10_6004_jnccn_2022_7008 crossref_primary_10_1007_s00117_016_0092_z crossref_primary_10_1002_jso_21636 crossref_primary_10_3389_fonc_2022_980659 crossref_primary_10_1007_s00595_015_1206_3 crossref_primary_10_4240_wjgs_v4_i5_104 crossref_primary_10_3390_cancers14194678 crossref_primary_10_1200_JCO_23_01311 crossref_primary_10_1016_j_soc_2014_07_002 crossref_primary_10_1177_03000605211063098 crossref_primary_10_1002_ags3_12434 crossref_primary_10_1016_j_ijrobp_2010_02_030 crossref_primary_10_1634_theoncologist_2010_0121 crossref_primary_10_1016_j_ejso_2023_06_012 crossref_primary_10_1007_s13126_012_0014_0 crossref_primary_10_1245_s10434_015_5006_1 crossref_primary_10_3748_wjg_v21_i31_9420 crossref_primary_10_6004_jnccn_2022_7018 crossref_primary_10_1007_s11605_013_2374_3 crossref_primary_10_1245_s10434_022_12566_1 crossref_primary_10_1093_jjco_hyaa035 crossref_primary_10_1155_2018_7675262 crossref_primary_10_1016_j_medcli_2010_01_006 crossref_primary_10_1007_s00423_014_1255_x crossref_primary_10_1016_j_jconrel_2017_07_040 crossref_primary_10_1016_j_yasu_2020_05_001 crossref_primary_10_1097_SLA_0000000000005330 crossref_primary_10_1002_cncr_26633 crossref_primary_10_1007_s00520_018_4493_6 crossref_primary_10_1186_s40792_017_0348_5 crossref_primary_10_1007_s00261_015_0420_1 crossref_primary_10_1016_j_bpg_2016_08_001 crossref_primary_10_1016_j_adro_2021_100763 crossref_primary_10_1245_s10434_016_5381_2 crossref_primary_10_1016_j_coph_2022_102305 crossref_primary_10_1093_annonc_mdq165 crossref_primary_10_1016_j_pan_2013_01_003 crossref_primary_10_1016_j_surg_2017_03_008 crossref_primary_10_36290_xon_2023_018 crossref_primary_10_1007_s13304_016_0392_x crossref_primary_10_1007_s13304_023_01628_y crossref_primary_10_1200_EDBK_175222 crossref_primary_10_1016_j_hpb_2019_01_012 crossref_primary_10_3109_00365521_2013_781218 crossref_primary_10_1097_MD_0000000000012260 crossref_primary_10_1177_1758835920936093 crossref_primary_10_2967_jnumed_115_158899 crossref_primary_10_1080_17474124_2016_1176910 crossref_primary_10_1002_jso_23606 crossref_primary_10_1007_s12032_017_0951_0 crossref_primary_10_3390_jcm8081205 crossref_primary_10_1016_j_ijrobp_2017_12_287 crossref_primary_10_1586_14737140_2014_952286 crossref_primary_10_1097_MPA_0000000000001547 crossref_primary_10_1111_ans_17999 crossref_primary_10_1245_s10434_019_07309_8 crossref_primary_10_2217_pme_12_111 crossref_primary_10_1097_PAT_0000000000000072 crossref_primary_10_1016_j_mpdhp_2016_05_002 crossref_primary_10_1097_SLA_0000000000003010 crossref_primary_10_1007_s11605_016_3149_4 crossref_primary_10_21294_1814_4861_2022_21_4_25_31 crossref_primary_10_1016_j_gtc_2016_04_003 crossref_primary_10_1016_j_radonc_2009_04_010 crossref_primary_10_1200_JCO_2011_36_0271 crossref_primary_10_1007_s10353_019_0577_x crossref_primary_10_1007_s00268_011_1113_8 crossref_primary_10_1007_s10353_019_0598_5 crossref_primary_10_1016_j_hpb_2016_05_003 crossref_primary_10_14701_ahbps_2021_25_3_358 crossref_primary_10_5858_arpa_2013_0335_OA crossref_primary_10_1007_s00595_019_01776_y crossref_primary_10_1016_j_surg_2015_07_001 crossref_primary_10_1245_s10434_014_3486_z crossref_primary_10_1016_j_gassur_2024_05_009 crossref_primary_10_1016_j_suronc_2023_101994 crossref_primary_10_1111_hpb_12325 crossref_primary_10_1007_s10269_015_2557_5 crossref_primary_10_12998_wjcc_v9_i20_5398 crossref_primary_10_1007_s11605_021_05235_3 crossref_primary_10_1007_s11864_017_0515_8 crossref_primary_10_1016_j_hpb_2021_04_004 crossref_primary_10_1159_000497827 crossref_primary_10_5348_100082Z04EC2019OA crossref_primary_10_4236_jct_2016_71004 crossref_primary_10_1007_s00423_021_02080_5 crossref_primary_10_1016_j_jcrpr_2017_10_001 crossref_primary_10_1007_s00268_010_0699_6 crossref_primary_10_1007_s10238_023_01013_4 crossref_primary_10_1007_s11605_010_1221_z crossref_primary_10_1002_jhbp_109 crossref_primary_10_4103_ijmpo_ijmpo_29_19 crossref_primary_10_1245_s10434_009_0410_z crossref_primary_10_1016_j_pan_2020_11_026 crossref_primary_10_1097_PPO_0000000000000206 crossref_primary_10_1007_s11912_016_0547_4 crossref_primary_10_3390_ijms18071338 crossref_primary_10_2958_suizo_28_34 crossref_primary_10_1016_j_surg_2018_04_014 crossref_primary_10_1016_j_critrevonc_2018_10_009 crossref_primary_10_2146_ajhp100254 crossref_primary_10_1007_s00261_021_03198_2 crossref_primary_10_1007_s10353_023_00814_x crossref_primary_10_2214_AJR_21_26931 crossref_primary_10_1097_COC_0000000000001076 crossref_primary_10_1111_j_1477_2574_2012_00445_x crossref_primary_10_1007_s00761_019_0546_9 crossref_primary_10_1007_s12262_011_0373_8 crossref_primary_10_1016_j_hpb_2020_03_017 crossref_primary_10_1016_j_pan_2020_05_020 crossref_primary_10_1002_cam4_5523 crossref_primary_10_1007_s00423_018_1724_8 crossref_primary_10_1093_annonc_mdt239 crossref_primary_10_1177_00031348241248703 crossref_primary_10_1245_s10434_008_0002_3 crossref_primary_10_1007_s00534_013_0612_4 crossref_primary_10_1002_cncr_27636 crossref_primary_10_1245_s10434_009_0762_4 crossref_primary_10_1016_j_hpb_2020_03_007 crossref_primary_10_1002_jso_21469 crossref_primary_10_3390_biomedicines10102480 crossref_primary_10_1007_s13566_013_0120_9 crossref_primary_10_1097_COC_0b013e31819171b9 crossref_primary_10_1007_s10620_011_1815_7 crossref_primary_10_1245_s10434_013_2882_0 crossref_primary_10_1016_j_jons_2016_10_002 crossref_primary_10_1007_s00740_020_00326_4 crossref_primary_10_1016_j_med_2021_01_004 crossref_primary_10_1016_j_sopen_2020_06_003 crossref_primary_10_1016_j_hpb_2022_09_012 crossref_primary_10_1097_SLA_0000000000004535 crossref_primary_10_1007_s00261_017_1432_9 crossref_primary_10_14701_ahbps_2018_22_4_386 crossref_primary_10_1016_S1499_3872_11_60070_2 crossref_primary_10_1177_1534735420986615 crossref_primary_10_1515_raon_2015_0017 crossref_primary_10_1053_j_seminoncol_2021_02_008 crossref_primary_10_3390_cancers12102871 crossref_primary_10_1002_cam4_1104 crossref_primary_10_1002_jhbp_1049 crossref_primary_10_1007_s11912_014_0388_y crossref_primary_10_1016_j_canrad_2008_11_008 crossref_primary_10_1016_j_ejso_2017_03_015 crossref_primary_10_1155_2016_6839687 crossref_primary_10_1148_radiol_2018171670 crossref_primary_10_1053_j_gastro_2013_01_078 crossref_primary_10_1055_a_1292_4956 crossref_primary_10_3748_wjg_v22_i2_764 crossref_primary_10_1634_theoncologist_2011_0268 crossref_primary_10_1200_JCO_2009_21_9022 crossref_primary_10_1016_j_ejso_2018_12_012 crossref_primary_10_1186_s12885_017_3441_z crossref_primary_10_1002_cncr_31936 crossref_primary_10_1016_j_suc_2008_09_022 crossref_primary_10_3389_fonc_2019_01060 crossref_primary_10_1016_j_surge_2019_07_004 crossref_primary_10_1007_s00595_020_01963_2 crossref_primary_10_12688_f1000research_16272_1 crossref_primary_10_3389_fonc_2020_00064 crossref_primary_10_1038_s41575_023_00856_2 crossref_primary_10_1111_j_1477_2574_2009_00150_x crossref_primary_10_5582_bst_2021_01459 crossref_primary_10_1016_j_ijsu_2016_08_523 crossref_primary_10_1111_ans_15721 crossref_primary_10_1159_000371745 crossref_primary_10_1245_s10434_024_15070_w crossref_primary_10_1097_MPA_0000000000001140 crossref_primary_10_3390_cancers12071729 crossref_primary_10_1007_s11864_020_00769_1 crossref_primary_10_3390_jcm12206461 crossref_primary_10_1007_s00535_016_1217_x crossref_primary_10_1007_s11912_012_0291_3 crossref_primary_10_1056_NEJMoa0903230 crossref_primary_10_5833_jjgs_2012_0140 crossref_primary_10_1007_s00104_008_1572_0 crossref_primary_10_1245_s10434_018_6512_8 crossref_primary_10_1007_s11605_011_1784_3 crossref_primary_10_1016_j_ctrv_2014_11_002 crossref_primary_10_1016_j_ijrobp_2015_12_003 crossref_primary_10_1001_jamaoncol_2018_0329 crossref_primary_10_1016_j_pan_2017_12_003 crossref_primary_10_1007_s11605_013_2371_6 crossref_primary_10_1002_jso_24538 crossref_primary_10_1097_MPA_0000000000000059 crossref_primary_10_1200_JOP_2016_020628 crossref_primary_10_1111_ans_14764 crossref_primary_10_1007_s10269_010_1954_z crossref_primary_10_1016_j_surg_2017_05_003 crossref_primary_10_1002_jhbp_844 crossref_primary_10_1097_SLA_0000000000002672 crossref_primary_10_4240_wjgs_v13_i6_516 crossref_primary_10_1002_cncr_28117 crossref_primary_10_1245_s10434_021_10686_8 crossref_primary_10_3389_fonc_2020_00041 crossref_primary_10_3390_ijms22042091 crossref_primary_10_1245_s10434_023_14219_3 crossref_primary_10_1007_s00330_021_07847_4 crossref_primary_10_1016_j_sopen_2023_03_001 crossref_primary_10_1016_j_suc_2024_03_004 crossref_primary_10_1111_j_1477_2574_2012_00508_x crossref_primary_10_1159_000445020 crossref_primary_10_1159_000445021 crossref_primary_10_1016_j_radonc_2014_09_010 crossref_primary_10_1097_MPA_0b013e318221c595 crossref_primary_10_3389_fonc_2019_01197 crossref_primary_10_15369_sujms_28_249 crossref_primary_10_1097_SLA_0000000000002783 crossref_primary_10_1016_j_canrad_2018_02_004 crossref_primary_10_1586_egh_11_39 crossref_primary_10_1016_j_suronc_2011_05_003 crossref_primary_10_1016_j_semradonc_2013_11_002 crossref_primary_10_1007_s11605_012_2063_7 crossref_primary_10_5348_ijhpd_2016_58_CR_14 crossref_primary_10_1016_j_ijrobp_2014_05_053 crossref_primary_10_1016_j_semradonc_2013_11_006 crossref_primary_10_1016_j_surg_2017_04_023 crossref_primary_10_4103_jco_jco_22_21 crossref_primary_10_1186_s12893_019_0644_z crossref_primary_10_1093_annonc_mds312 crossref_primary_10_1002_jhbp_748 crossref_primary_10_1245_s10434_009_0413_9 crossref_primary_10_1245_s10434_015_4437_z crossref_primary_10_1016_j_jss_2022_10_008 crossref_primary_10_1016_j_ciresp_2013_11_001 crossref_primary_10_1016_j_ijrobp_2013_02_022 crossref_primary_10_3390_cancers10030065 crossref_primary_10_1245_s10434_011_2156_7 crossref_primary_10_1007_s10637_018_0691_9 crossref_primary_10_1016_j_surg_2022_10_025 crossref_primary_10_1002_jso_26989 crossref_primary_10_36472_msd_v9i5_722 crossref_primary_10_1056_NEJMra0901557 crossref_primary_10_1016_j_adro_2019_08_014 crossref_primary_10_3389_fonc_2020_01112 crossref_primary_10_1007_s11605_016_3265_1 crossref_primary_10_1016_j_ijrobp_2009_01_047 crossref_primary_10_1245_s10434_010_1460_y crossref_primary_10_1111_1751_2980_12551 crossref_primary_10_1245_s10434_011_1693_4 crossref_primary_10_1245_s10434_017_5972_6 crossref_primary_10_1155_2015_269641 crossref_primary_10_1001_jamasurg_2019_0502 crossref_primary_10_1016_j_radonc_2021_07_009 crossref_primary_10_3390_cancers13174396 crossref_primary_10_1007_s10353_013_0213_0 crossref_primary_10_14701_ahbps_2021_25_2_179 crossref_primary_10_3748_wjg_v27_i39_6572 crossref_primary_10_1002_cncr_25069 crossref_primary_10_1016_j_ejso_2017_10_217 crossref_primary_10_5833_jjgs_2012_0342 crossref_primary_10_3748_wjg_v20_i30_10405 crossref_primary_10_4236_jct_2014_51012 crossref_primary_10_1007_s00268_012_1618_9 crossref_primary_10_1245_s10434_010_1285_8 crossref_primary_10_3109_0284186X_2014_1000466 crossref_primary_10_1097_MPA_0000000000001105 crossref_primary_10_5582_bst_2022_01250 crossref_primary_10_1067_j_cpsurg_2015_07_003 crossref_primary_10_1016_j_ejso_2018_07_047 crossref_primary_10_1016_j_jss_2015_01_045 crossref_primary_10_1007_s00268_014_2484_4 crossref_primary_10_1245_s10434_011_2211_4 crossref_primary_10_1097_SLA_0000000000001547 crossref_primary_10_1007_s00268_015_3096_3 crossref_primary_10_3389_fsurg_2023_1119557 crossref_primary_10_1016_j_hpb_2021_09_002 crossref_primary_10_1245_s10434_023_14680_0 crossref_primary_10_1016_j_hpb_2018_10_009 crossref_primary_10_1111_ans_17151 crossref_primary_10_1007_s00423_020_02025_4 crossref_primary_10_1053_j_seminoncol_2014_12_008 crossref_primary_10_1053_j_seminoncol_2014_12_009 crossref_primary_10_1007_s11605_018_4041_1 crossref_primary_10_3390_jcm9123945 crossref_primary_10_1586_era_11_125 crossref_primary_10_3892_ol_2016_4128 crossref_primary_10_1016_j_adro_2018_07_002 crossref_primary_10_1002_jso_25681 crossref_primary_10_1002_jso_26650 crossref_primary_10_3390_cancers12123635 crossref_primary_10_1634_theoncologist_2015_0316 crossref_primary_10_1007_s00268_013_2384_z crossref_primary_10_3390_curroncol31040167 crossref_primary_10_3748_wjg_v20_i32_11210 crossref_primary_10_1245_s10434_010_1284_9 crossref_primary_10_1007_s11605_017_3595_7 crossref_primary_10_1007_s12262_008_0076_y crossref_primary_10_1053_j_seminoncol_2014_12_013 crossref_primary_10_1016_j_ejso_2019_04_007 crossref_primary_10_1007_s11605_016_3286_9 crossref_primary_10_1007_s00595_010_4419_5 crossref_primary_10_1093_annonc_mdx004 crossref_primary_10_1245_s10434_020_08427_4 crossref_primary_10_1002_jso_23392 crossref_primary_10_1586_14737140_8_10_1611 crossref_primary_10_1111_den_12049 crossref_primary_10_1097_SLA_0000000000000310 crossref_primary_10_1016_j_soc_2017_01_012 crossref_primary_10_5009_gnl20070 crossref_primary_10_1002_jhbp_700 crossref_primary_10_1016_j_ejso_2009_06_005 crossref_primary_10_1016_j_suc_2009_12_001 crossref_primary_10_1016_j_pan_2013_07_064 crossref_primary_10_1016_j_inoche_2021_109018 crossref_primary_10_1097_JP9_0000000000000009 crossref_primary_10_1136_jclinpath_2016_203947 crossref_primary_10_1093_annonc_mdx255 crossref_primary_10_1016_j_humpath_2017_05_023 crossref_primary_10_1053_j_seminoncol_2012_05_015 crossref_primary_10_1007_s00280_016_3121_8 crossref_primary_10_1016_j_adro_2018_08_025 crossref_primary_10_3748_wjg_v21_i8_2281 crossref_primary_10_3390_cancers12123656 crossref_primary_10_1245_s10434_013_3237_6 crossref_primary_10_1016_j_suronc_2023_102027 crossref_primary_10_1016_j_asjsur_2020_07_021 crossref_primary_10_1007_s11605_013_2412_1 crossref_primary_10_1245_s10434_017_6098_6 crossref_primary_10_2958_suizo_33_27 crossref_primary_10_3389_fonc_2018_00012 crossref_primary_10_2217_fon_15_335 crossref_primary_10_1016_j_critrevonc_2015_11_016 crossref_primary_10_1016_j_hoc_2015_04_004 crossref_primary_10_1111_hpb_12074 crossref_primary_10_1111_hpb_12073 crossref_primary_10_4240_wjgs_v5_i3_27 crossref_primary_10_1111_j_1477_2574_2009_00136_x crossref_primary_10_1016_S1470_2045_23_00478_3 crossref_primary_10_1159_000538627 crossref_primary_10_1097_SLA_0000000000002957 crossref_primary_10_3109_0284186X_2013_771821 crossref_primary_10_1007_s11605_008_0788_0 crossref_primary_10_1007_s00595_016_1310_z crossref_primary_10_1016_S1499_3872_11_60053_2 crossref_primary_10_1158_0008_5472_CAN_14_2645 crossref_primary_10_3748_wjg_v21_i31_9297 crossref_primary_10_1200_JCO_2014_59_7930 crossref_primary_10_1007_s00423_013_1072_7 crossref_primary_10_1016_j_ejso_2013_07_089 crossref_primary_10_1148_radiol_2018180628 crossref_primary_10_1016_j_cireng_2013_11_014 crossref_primary_10_1097_SLA_0000000000002705 crossref_primary_10_1245_s10434_020_09520_4 crossref_primary_10_14701_ahbps_2018_22_3_261 crossref_primary_10_1038_s41571_023_00746_1 crossref_primary_10_3748_wjg_v20_i46_17448 crossref_primary_10_1123_jpah_2019_0027 crossref_primary_10_1038_nrgastro_2010_98 crossref_primary_10_51847_RxWepx87LV crossref_primary_10_1200_EDBK_160827 crossref_primary_10_1080_0284186X_2017_1415458 crossref_primary_10_1155_2014_183852 crossref_primary_10_1245_s10434_015_4783_x crossref_primary_10_2214_AJR_11_7058 crossref_primary_10_1002_jhbp_1245 crossref_primary_10_1007_s00423_022_02689_0 crossref_primary_10_1093_annonc_mdx180 crossref_primary_10_1016_j_disamonth_2013_08_001 crossref_primary_10_1245_s10434_008_0295_2 crossref_primary_10_1245_s10434_021_11206_4 crossref_primary_10_1016_j_amjsurg_2010_01_021 crossref_primary_10_4045_tidsskr_11_1242 crossref_primary_10_1001_jamaoncol_2022_2319 crossref_primary_10_1016_j_jss_2016_01_021 crossref_primary_10_1007_s11605_011_1493_y crossref_primary_10_1016_j_neo_2020_12_008 crossref_primary_10_1097_COC_0000000000000433 crossref_primary_10_1097_SLA_0000000000000996 crossref_primary_10_1186_1477_7819_11_37 crossref_primary_10_1634_theoncologist_2018_0114 crossref_primary_10_1016_j_surg_2014_01_003 crossref_primary_10_1002_jso_25498 crossref_primary_10_1002_jso_26103 crossref_primary_10_1016_j_soc_2009_11_006 crossref_primary_10_1177_1758835919875568 crossref_primary_10_1016_j_soc_2009_11_007 crossref_primary_10_1200_JOP_2016_016162 crossref_primary_10_1007_s00261_016_0815_7 crossref_primary_10_1002_bjs5_50175 crossref_primary_10_1016_j_pan_2017_11_011 crossref_primary_10_1007_s00423_017_1562_0 crossref_primary_10_3322_caac_21190 crossref_primary_10_3390_cancers15164174 crossref_primary_10_1016_j_hbpd_2019_05_007 crossref_primary_10_1002_jso_25024 crossref_primary_10_1016_j_medcli_2009_12_014 crossref_primary_10_3109_0284186X_2015_1004367 crossref_primary_10_3748_wjg_v22_i48_10502 crossref_primary_10_1016_j_ctro_2021_12_012 crossref_primary_10_1007_s00066_017_1227_5 crossref_primary_10_1007_s13193_010_0017_7 crossref_primary_10_1016_j_surg_2021_10_018 crossref_primary_10_1245_s10434_013_2889_6 crossref_primary_10_4240_wjgs_v5_i2_12 crossref_primary_10_1007_s13304_024_01860_0 |
| ContentType | Journal Article |
| Copyright | American College of Surgeons 2008 American College of Surgeons |
| Copyright_xml | – notice: American College of Surgeons – notice: 2008 American College of Surgeons |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 5PM |
| DOI | 10.1016/j.jamcollsurg.2007.12.020 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| EISSN | 1879-1190 |
| EndPage | 846 |
| ExternalDocumentID | 10_1016_j_jamcollsurg_2007_12_020 18471707 S1072751507019813 1_s2_0_S1072751507019813 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NCI NIH HHS grantid: P20 CA101936 – fundername: NCI NIH HHS grantid: P30 CA016672 – fundername: NCI NIH HHS grantid: CA101936-01 |
| GroupedDBID | --- --K --M -RU .55 .GJ .~1 0R~ 1B1 1CY 1KJ 1P~ 1~. 1~5 29L 2QL 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 6PF 7-5 71M 8P~ AAAAV AABNK AACTN AAEDT AAEDW AAGIX AAIKJ AAIQE AAJCS AAKOC AALRI AAOAW AAQFI AAQOH AAQQT AAQXK AAWTL AAXUO ABBQC ABFRF ABJNI ABMAC ABMZM ABOCM ABPPZ ABXDB ACBMB ACDAQ ACGFO ACGFS ACILI ACIUM ACLDA ACRLP ACXJB ADBBV ADEZE ADMUD AEBDS AEFWE AEKER AENEX AEVXI AFEXH AFFNX AFKWA AFRHN AFTJW AFXIZ AGHFR AGUBO AGYEJ AHOMT AHQNM AI. AIKHN AITUG AJNWD AJOXV AJRQY AJZMW AKRWK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AZFZN BKOJK BLXMC BNPGV CS3 DU5 EBS EEVPB EJD EO9 EP2 EP3 ERAAH EX3 F5P FCALG FDB FEDTE FGOYB FIRID FNPLU GBLVA HVGLF HZ~ IH2 IHE J1W J5H KOM L7B LXL LXN M41 MO0 N4W N9A O-L O9- OAUVE OHT OVD OZT P-8 P-9 P2P PC. PQQKQ Q38 R2- RIG RLZ ROL RPZ SDF SDG SEL SES SEW SJN SPCBC SSZ T5K TEORI UHB UV1 UXK VH1 WH7 WOW X7M ZGI ZRR ZXP ~G- AAIAV ABLVK ABYKQ AHPSJ AJBFU EFLBG LCYCR SSH ZA5 CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 5PM |
| ID | FETCH-LOGICAL-c536t-e20d0a9ec2ccaa00ff440ab449c2295c7e0fb4251f7bfd7c1b5de932a519db403 |
| IEDL.DBID | .~1 |
| ISSN | 1072-7515 |
| IngestDate | Tue Sep 17 21:11:16 EDT 2024 Sat Aug 17 04:47:23 EDT 2024 Fri Aug 23 01:13:54 EDT 2024 Wed Oct 23 09:32:32 EDT 2024 Fri Feb 23 02:29:59 EST 2024 Tue Oct 15 22:55:48 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Keywords | CA 19-9 PA pancreatic adenocarcinoma portal vein superior mesenteric artery American Joint Committee on Cancer PV SMA AJCC cancer antigen 19-9 superior mesenteric vein SMV |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c536t-e20d0a9ec2ccaa00ff440ab449c2295c7e0fb4251f7bfd7c1b5de932a519db403 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://europepmc.org/articles/pmc5901743?pdf=render |
| PMID | 18471707 |
| PQID | 69205131 |
| PQPubID | 23479 |
| PageCount | 14 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_5901743 proquest_miscellaneous_69205131 crossref_primary_10_1016_j_jamcollsurg_2007_12_020 pubmed_primary_18471707 elsevier_sciencedirect_doi_10_1016_j_jamcollsurg_2007_12_020 elsevier_clinicalkeyesjournals_1_s2_0_S1072751507019813 |
| PublicationCentury | 2000 |
| PublicationDate | 2008-05-01 |
| PublicationDateYYYYMMDD | 2008-05-01 |
| PublicationDate_xml | – month: 05 year: 2008 text: 2008-05-01 day: 01 |
| PublicationDecade | 2000 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Journal of the American College of Surgeons |
| PublicationTitleAlternate | J Am Coll Surg |
| PublicationYear | 2008 |
| Publisher | Elsevier Inc |
| Publisher_xml | – name: Elsevier Inc |
| References | Evans, Lee, Tamm, Pisters (bib6) 2007 Oken, Creech, Tormey (bib5) 1982; 5 Tseng, Raut, Lee (bib9) 2004; 8 (bib12) 2002 Wolff, Crane, Li (bib2) 2006 Pisters, Hudec, Hess (bib10) 2001; 234 Evans, Rich, Byrd (bib13) 1992; 127 Yen, Abdalla, Pisters, Evans (bib8) 2005 Staley, Cleary, Abbruzzese (bib11) 1996; 12 Raut, Tseng, Sun (bib1) 2007; 246 bib3 Varadhachary, Tamm, Abbruzzese (bib4) 2006; 13 Gallagher, Zervos, Murr (bib7) 2005 |
| References_xml | – start-page: 299 year: 2005 end-page: 312 ident: bib8 article-title: Pancreaticoduodenectomy publication-title: Pancreatic cancer contributor: fullname: Evans – volume: 13 start-page: 1035 year: 2006 end-page: 1046 ident: bib4 article-title: Borderline resectable pancreatic cancer: definitions, management, and role of preoperative therapy publication-title: Ann Surg Oncol contributor: fullname: Abbruzzese – volume: 127 start-page: 1335 year: 1992 end-page: 1339 ident: bib13 article-title: Preoperative chemoradiation and pancreaticoduodenectomy for adenocarcinoma of the pancreas publication-title: Arch Surg contributor: fullname: Byrd – volume: 5 start-page: 649 year: 1982 end-page: 655 ident: bib5 article-title: Toxicity and response criteria of the Eastern Cooperative Oncology Group publication-title: Am J Clin Oncol contributor: fullname: Tormey – start-page: 299 year: 2005 end-page: 312 ident: bib7 article-title: Distal pancreatectomy publication-title: Pancreatic cancer contributor: fullname: Murr – volume: 234 start-page: 47 year: 2001 end-page: 55 ident: bib10 article-title: Effect of preoperative biliary decompression on pancreaticoduodenectomy-associated morbidity in 300 consecutive patients publication-title: Ann Surg contributor: fullname: Hess – ident: bib3 article-title: National Comprehensive Cancer Network (NCCN) clinical practice guidelines in oncology – start-page: 157 year: 2002 end-page: 164 ident: bib12 article-title: Exocrine pancreas publication-title: AJCC cancer staging manual – start-page: 1331 year: 2006 end-page: 1358 ident: bib2 article-title: Neoplasms of the exocrine pancreas publication-title: Cancer medicine contributor: fullname: Li – volume: 246 start-page: 52 year: 2007 end-page: 60 ident: bib1 article-title: Impact of resection status on pattern of failure and survival after pancreaticoduodenectomy for pancreatic adenocarcinoma publication-title: Ann Surg contributor: fullname: Sun – volume: 8 start-page: 935 year: 2004 end-page: 949 ident: bib9 article-title: Pancreaticoduodenectomy with vascular resection: margin status and survival duration publication-title: J Gastrointest Surg contributor: fullname: Lee – start-page: 1299 year: 2007 end-page: 1317 ident: bib6 article-title: Pancreaticoduodenectomy (Whipple operation) and total pancreatectomy for cancer publication-title: Mastery of surgery contributor: fullname: Pisters – volume: 12 start-page: 373 year: 1996 end-page: 380 ident: bib11 article-title: The need for standardized pathologic staging of pancreaticoduodenectomy specimens publication-title: Pancreas contributor: fullname: Abbruzzese |
| SSID | ssj0017096 |
| Score | 2.5281596 |
| Snippet | Background Patients with borderline resectable pancreatic adenocarcinoma (PA) include those with localized disease who have tumor or patient characteristics... Patients with borderline resectable pancreatic adenocarcinoma (PA) include those with localized disease who have tumor or patient characteristics that preclude... BACKGROUNDPatients with borderline resectable pancreatic adenocarcinoma (PA) include those with localized disease who have tumor or patient characteristics... |
| SourceID | pubmedcentral proquest crossref pubmed elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 833 |
| SubjectTerms | Adenocarcinoma - classification Adenocarcinoma - pathology Adenocarcinoma - surgery Adenocarcinoma - therapy Adult Aged Aged, 80 and over Antineoplastic Agents - administration & dosage Female Humans Male Middle Aged Neoadjuvant Therapy Neoplasm Staging Pancreatectomy Pancreatic Neoplasms - classification Pancreatic Neoplasms - pathology Pancreatic Neoplasms - surgery Pancreatic Neoplasms - therapy Radiotherapy Surgery |
| Title | Borderline Resectable Pancreatic Cancer: The Importance of This Emerging Stage of Disease |
| URI | https://www.clinicalkey.es/playcontent/1-s2.0-S1072751507019813 https://dx.doi.org/10.1016/j.jamcollsurg.2007.12.020 https://www.ncbi.nlm.nih.gov/pubmed/18471707 https://www.proquest.com/docview/69205131/abstract/ https://pubmed.ncbi.nlm.nih.gov/PMC5901743 |
| Volume | 206 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3dS8MwEA-iIL6I4tf8jOBrXdqmzSq-6FRUUAQdzKfQpMncwE7W7dW_3bu0nU59EHzpQ3ql6d3l7pf0Pgg5AgitQqatx6MQLtbGXsqF8RID_kFoHVpXSunuPr7u8Ntu1J0j7ToXBsMqK9tf2nRnrauRZsXN5lu_33yEjUsgIgQ0AFNa2Ll2QaBDBqU-fp_GefiCuSZdSO0h-SI5_AzyGqSvyO9iMuqV5QzxaBB7f__upH6C0O-xlF-c09UKWa5QJT0rJ75K5ky-Rp7PXV1NxJEUA-z0GNOk6API2SFFTdso8tEJBV2hN68OicMAHVoY6RcUD6ywhxEFRNpzwxfl75x10rm6fGpfe1UnBU9HYTz2TMAyliZGByCwlDFrOWep4jzR2M5bC8OsgtXrW6FsJrSvoswAsksB32WKs3CDzOfD3GwRCjtCk_kBiw3uDS1PWNIykeKiFacqaSUNEtSsk29lwQxZR5IN5Bd-YwNMIf1AAr8bRNRMlnVGKNgwU1QLqpC-LIBS_hB6g5xOn5zRGwku4S8vPqhFKmFd4c-SNDfDSSHjJAB7FfoNslkK-PNr0KELJmDSM6KfEmDF7tk7ef_FVe7GRF-AbNv_m_QOWSqjVjDscpfMj0cTswfQaKz2nep_ADSID2Y |
| link.rule.ids | 230,315,786,790,891,4521,27955,27956,45618,70617 |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1NT9wwEB0hkAoX1KoFFkpxJa5hncSJN6iXsgUt5UOVAAlOVuzYsEhk0Wb3ym9nxkkWtnCo1EsOzkRxZuKZZ_t5BmAXIbSOuXGBSGK8OJcGuZA2yCzGB2lM7HwqpbPzdHAlfl8n1wvQb8_CEK2y8f21T_feumnpNtrsPg6H3QucuEQyIUCDMKVHlWuXCA0Qr2vvacbzCCX3RbpIOiDxD_D9heR1nz-Qvqvp-LZOZ0hLg1T7-_0g9RaE_s2lfBWcjj7CaoMq2c-6459gwZaf4ebA59UkHMmIYGcmdEyK_UE7e6RoWJ9MPt5n-K-w4wePxLGBjRy2DCtGC1ZUw4ghIr31zb_q7ZwvcHV0eNkfBE0lhcAkcToJbMQLnmfWRGiwnHPnhOC5FiIzVM7bSMudxtEbOqldIU2ok8IisssR3xVa8HgNFstRaTeA4YzQFmHEU0tzQycynvVsooXspbnOelkHolZ16rFOmKFaJtm9eqVvKoApVRgp1HcHZKtk1Z4IRR9mq2ZAVSpUFUqqN0bvwI_Zk3P_jcKQ8C8v3mlNqnBc0WZJXtrRtFJpFqG_isMOrNcGfvkaCuiSS-z0nOlnApSxe_5OObzzmbvpoC9Cts3_6_QOLA8uz07V6fH5yRas1AwWomB-hcXJeGq3ESZN9Dc_DJ4BF1ISUw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=BORDERLINE+RESECTABLE+PANCREATIC+CANCER%3A+THE+IMPORTANCE+OF+THIS+EMERGING+STAGE+OF+DISEASE&rft.jtitle=Journal+of+the+American+College+of+Surgeons&rft.au=Katz%2C+Matthew+H.+G.&rft.au=Pisters%2C+Peter+WT&rft.au=Evans%2C+Douglas+B.&rft.au=Sun%2C+Charlotte+C.&rft.date=2008-05-01&rft.issn=1072-7515&rft.eissn=1879-1190&rft.volume=206&rft.issue=5&rft.spage=833&rft.epage=848&rft_id=info:doi/10.1016%2Fj.jamcollsurg.2007.12.020&rft_id=info%3Apmid%2F18471707&rft.externalDBID=PMC5901743 |
| thumbnail_m | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F10727515%2FS1072751508X00043%2Fcov150h.gif |