High-Yield Resveratrol Production in Engineered Escherichia coli

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Published inApplied and Environmental Microbiology Vol. 77; no. 10; pp. 3451 - 3460
Main Authors Lim, Chin Giaw, Fowler, Zachary L., Hueller, Thomas, Schaffer, Steffen, Koffas, Mattheos A. G.
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.05.2011
Subjects
Acyltransferases - genetics
Acyltransferases - metabolism
Biotechnology
Cardiovascular diseases
Chromatography, High Pressure Liquid
diabetes
E coli
Escherichia coli
Escherichia coli - genetics
Escherichia coli - metabolism
Gene Expression
Health promotion
heart diseases
host strains
humans
Industrial production
Metabolic Networks and Pathways - genetics
Metabolism
Microbiology
Microorganisms
Plant Proteins - genetics
Plant Proteins - metabolism
Plant species
Polyphenols
protein sources
Recombinant Proteins - genetics
Recombinant Proteins - metabolism
resveratrol
Stilbenes - metabolism
structure-activity relationships
therapeutics
Tissue engineering
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Abstract Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue AEM About AEM Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AEM RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0099-2240 Online ISSN: 1098-5336 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AEM .asm.org, visit: AEM       
AbstractList Plant polyphenols have been the subject of several recent scientific investigations since many of the molecules in this class have been found to be highly active in the human body, with a plethora of health-promoting activities against a variety of diseases, including heart disease, diabetes, and cancer, and with even the potential to slow aging. Further development of these potent natural therapeutics hinges on the formation of robust industrial production platforms designed using specifically selected as well as engineered protein sources along with the construction of optimal expression platforms. In this work, we first report the investigation of various stilbene synthases from an array of plant species considering structure-activity relationships, their expression efficiency in microorganisms, and their ability to synthesize resveratrol. Second, we looked into the construct environment of recombinantly expressed stilbene synthases, including different promoters, construct designs, and host strains, to create an Escherichia coli strain capable of producing superior resveratrol titers sufficient for commercial usage. Further improvement of metabolic capabilities of the recombinant strain aimed at improving the intracellular malonyl-coenzyme A pool, a resveratrol precursor, resulted in a final improved titer of 2.3 g/liter resveratrol.
Plant polyphenols have been the subject of several recent scientific investigations since many of the molecules in this class have been found to be highly active in the human body, with a plethora of health-promoting activities against a variety of diseases, including heart disease, diabetes, and cancer, and with even the potential to slow aging. Further development of these potent natural therapeutics hinges on the formation of robust industrial production platforms designed using specifically selected as well as engineered protein sources along with the construction of optimal expression platforms. In this work, we first report the investigation of various stilbene synthases from an array of plant species considering structure-activity relationships, their expression efficiency in microorganisms, and their ability to synthesize resveratrol. Second, we looked into the construct environment of recombinantly expressed stilbene synthases, including different promoters, construct designs, and host strains, to create an Escherichia coli strain capable of producing superior resveratrol titers sufficient for commercial usage. Further improvement of metabolic capabilities of the recombinant strain aimed at improving the intracellular malonyl-coenzyme A pool, a resveratrol precursor, resulted in a final improved titer of 2.3 g/liter resveratrol.Plant polyphenols have been the subject of several recent scientific investigations since many of the molecules in this class have been found to be highly active in the human body, with a plethora of health-promoting activities against a variety of diseases, including heart disease, diabetes, and cancer, and with even the potential to slow aging. Further development of these potent natural therapeutics hinges on the formation of robust industrial production platforms designed using specifically selected as well as engineered protein sources along with the construction of optimal expression platforms. In this work, we first report the investigation of various stilbene synthases from an array of plant species considering structure-activity relationships, their expression efficiency in microorganisms, and their ability to synthesize resveratrol. Second, we looked into the construct environment of recombinantly expressed stilbene synthases, including different promoters, construct designs, and host strains, to create an Escherichia coli strain capable of producing superior resveratrol titers sufficient for commercial usage. Further improvement of metabolic capabilities of the recombinant strain aimed at improving the intracellular malonyl-coenzyme A pool, a resveratrol precursor, resulted in a final improved titer of 2.3 g/liter resveratrol.
Plant polyphenols have been the subject of several recent scientific investigations since many of the molecules in this class have been found to be highly active in the human body, with a plethora of health-promoting activities against a variety of diseases, including heart disease, diabetes, and cancer, and with even the potential to slow aging. Further development of these potent natural therapeutics hinges on the formation of robust industrial production platforms designed using specifically selected as well as engineered protein sources along with the construction of optimal expression platforms. In this work, we first report the investigation of various stilbene synthases from an array of plant species considering structure-activity relationships, their expression efficiency in microorganisms, and their ability to synthesize resveratrol. Second, we looked into the construct environment of recombinantly expressed stilbene synthases, including different promoters, construct designs, and host strains, to create an Escherichia coli strain capable of producing superior resveratrol titers sufficient for commercial usage. Further improvement of metabolic capabilities of the recombinant strain aimed at improving the intracellular malonyl-coenzyme A pool, a resveratrol precursor, resulted in a final improved titer of 2.3 g/liter resveratrol. [PUBLICATION ABSTRACT]
Plant polyphenols have been the subject of several recent scientific investigations since many of the molecules in this class have been found to be highly active in the human body, with a plethora of health-promoting activities against a variety of diseases, including heart disease, diabetes, and cancer, and with even the potential to slow aging. Further development of these potent natural therapeutics hinges on the formation of robust industrial production platforms designed using specifically selected as well as engineered protein sources along with the construction of optimal expression platforms. In this work, we first report the investigation of various stilbene synthases from an array of plant species considering structure-activity relationships, their expression efficiency in microorganisms, and their ability to synthesize resveratrol. Second, we looked into the construct environment of recombinantly expressed stilbene synthases, including different promoters, construct designs, and host strains, to create an Escherichia coli strain capable of producing superior resveratrol titers sufficient for commercial usage. Further improvement of metabolic capabilities of the recombinant strain aimed at improving the intracellular malonyl-coenzyme A pool, a resveratrol precursor, resulted in a final improved titer of 2.3 g/liter resveratrol.
Classifications Services AEM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue AEM About AEM Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy AEM RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0099-2240 Online ISSN: 1098-5336 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to AEM .asm.org, visit: AEM       
Author Thomas Hueller
Chin Giaw Lim
Zachary L. Fowler
Steffen Schaffer
Mattheos A. G. Koffas
Author_xml – sequence: 1
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  surname: Lim
  fullname: Lim, Chin Giaw
  organization: Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260
– sequence: 2
  givenname: Zachary L.
  surname: Fowler
  fullname: Fowler, Zachary L.
  organization: Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260
– sequence: 3
  givenname: Thomas
  surname: Hueller
  fullname: Hueller, Thomas
  organization: Evonik Degussa GmbH, Creavis Technologies & Innovation, Paul-Baumann-Strasse 1, D-45772 Marl, Germany
– sequence: 4
  givenname: Steffen
  surname: Schaffer
  fullname: Schaffer, Steffen
  organization: Evonik Degussa GmbH, Creavis Technologies & Innovation, Paul-Baumann-Strasse 1, D-45772 Marl, Germany
– sequence: 5
  givenname: Mattheos A. G.
  surname: Koffas
  fullname: Koffas, Mattheos A. G.
  organization: Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York, Buffalo, New York 14260
BackLink https://www.ncbi.nlm.nih.gov/pubmed/21441338$$D View this record in MEDLINE/PubMed
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Copyright Copyright American Society for Microbiology May 2011
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Plant polyphenols have been the subject of several recent scientific investigations since many of the molecules in this class have been found to be highly...
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SubjectTerms Acyltransferases - genetics
Acyltransferases - metabolism
Biotechnology
Cardiovascular diseases
Chromatography, High Pressure Liquid
diabetes
E coli
Escherichia coli
Escherichia coli - genetics
Escherichia coli - metabolism
Gene Expression
Health promotion
heart diseases
host strains
humans
Industrial production
Metabolic Networks and Pathways - genetics
Metabolism
Microbiology
Microorganisms
Plant Proteins - genetics
Plant Proteins - metabolism
Plant species
Polyphenols
protein sources
Recombinant Proteins - genetics
Recombinant Proteins - metabolism
resveratrol
Stilbenes - metabolism
structure-activity relationships
therapeutics
Tissue engineering
Title High-Yield Resveratrol Production in Engineered Escherichia coli
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