A UPLC/DAD method for simultaneous determination of empagliflozin and three related substances in spiked human plasma

• Published in: BMC chemistry Vol. 13; no. 1; pp. 83 - 9
• Main Authors: Mabrouk, Mokhtar M., Soliman, Suzan M., El-Agizy, Heba M., Mansour, Fotouh R.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 09.07.2019; Springer Nature B.V; BMC
• Subjects: Acetonitrile; Analytical Chemistry; Blood plasma; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Chromatography; Empagliflozin; Flow velocity; Ions; Plasma; Related substances; Research Article; Spiked human plasma; Tetrahydrofuran; THF protein precipitation; UPLC; Related substances; Empagliflozin; Spiked human plasma; THF protein precipitation; UPLC

A simple, rapid and sensitive ultrahigh performance liquid chromatographic method was developed for the determination of the anti-diabetic drug: empagliflozin (EMPA) and three related substances in spiked human plasma, using dapagliflozin (DAPA) as an internal standard and tetrahydrofuran as a plasm...