Antiangiogenesis effect of timosaponin AIII on HUVECs in vitro and zebrafish embryos in vivo - Zhou, Zhong-yan; Zhao, Wai-rong; Xiao, Ying; Zhou, Xiang-ming; Huang, Chen; Shi, Wen-ting; Zhang, Jing; Ye, Qing; Chen, Xin-lin; Tang, Jing-yi (Acta pharmacologica Sinica, 2020)
Keywords: 1-Phosphatidylinositol 3-kinase; AKT protein; Angiogenesis; Angiogenesis Inhibitors - administration & dosage; Angiogenesis Inhibitors - pharmacology; Animals; Biomedical and Life Sciences; Biomedicine; Cell adhesion; Cell adhesion & migration; Cell Adhesion - drug effects; Cell Movement - drug effects; Cell Proliferation - drug effects; Cytotoxicity; Danio rerio; Dose-Response Relationship, Drug; Embryos; Endothelial cells; Extracellular signal-regulated kinase; Gene expression; Herbal medicine; Human Umbilical Vein Endothelial Cells - drug effects; Humans; Immunology; Internal Medicine; Kinases; MAP kinase; MAP Kinase Signaling System - drug effects; Medical Microbiology; Oncogene Protein v-akt - metabolism; Pharmacology/Toxicology; Phosphatidylinositol 3-Kinases - metabolism; Phosphorylation; Protein-serine/threonine kinase; Ribonucleic acid; RNA; Saponins; Saponins - administration & dosage; Saponins - pharmacology; Signal Transduction - drug effects; Steroids - administration & dosage; Steroids - pharmacology; Umbilical vein; Vaccine; Vascular endothelial growth factor; Vascular Endothelial Growth Factor A - metabolism; Vascular endothelial growth factor receptors; Zebrafish; Neoplasm; Traditional Chinese herbal; Transcriptome; VEGF/PI3K/Akt/MAPK; Zebrafish; Timosaponin AIII; Neovascularization; HUVECs; SU5416