The paracrine induction of prostate cancer progression by caveolin-1

• Published in: Cell death & disease Vol. 10; no. 11; pp. 834 - 15
• Main Authors: Lin, Chun-Jung, Yun, Eun-Jin, Lo, U-Ging, Tai, Yu-Ling, Deng, Su, Hernandez, Elizabeth, Dang, Andrew, Chen, Yu-An, Saha, Debabrata, Mu, Ping, Lin, Ho, Li, Tsai-Kun, Shen, Tang-Long, Lai, Chih-Ho, Hsieh, Jer-Tsong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.11.2019; Springer Nature B.V
• Subjects: 13/100; 13/106; 13/109; 13/31; 38/1; 38/39; 38/77; 38/90; 631/67/71; 692/699/67/589/466; 96/95; Animals; Antibodies; Biochemistry; Biomedical and Life Sciences; Castration; Caveolin; Caveolin 1 - metabolism; Caveolin-1; Cell Biology; Cell Culture; Cell Line, Tumor; Chemoresistance; Exosomes; Exosomes - metabolism; Exosomes - pathology; Humans; Immunology; Life Sciences; Male; Mesenchyme; Metastases; Mice; Mice, SCID; Neoplasm Proteins - metabolism; NF-κB protein; Paracrine Communication; Paracrine signalling; Phenotypes; Prostate cancer; Prostatic Neoplasms, Castration-Resistant - metabolism; Prostatic Neoplasms, Castration-Resistant - pathology; Signal Transduction; Stem cells; Tumor cells

A subpopulation of cancer stem cells (CSCs) plays a critical role of cancer progression, recurrence, and therapeutic resistance. Many studies have indicated that castration-resistant prostate cancer (CRPC) is associated with stem cell phenotypes, which could further promote neuroendocrine transdiffe...