Combination of apolipoprotein-A-I/apolipoprotein-A-I binding protein and anti-VEGF treatment overcomes anti-VEGF resistance in choroidal neovascularization in mice

• Published in: Communications biology Vol. 3; no. 1; p. 386
• Main Authors: Zhu, Lingping, Parker, Mackenzie, Enemchukwu, Nduka, Shen, Megan, Zhang, Guogang, Yan, Qing, Handa, James T., Fang, Longhou, Fu, Yingbin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.07.2020; Nature Publishing Group
• Subjects: 13/106; 14/19; 14/32; 631/378/2613; 64/60; 692/699/3161/1626; Angiogenesis; Apolipoprotein A; Apolipoprotein A-I; Apolipoproteins; Biology; Biomedical and Life Sciences; Cholesterol; Endothelial cells; Life Sciences; Lipids; Macrophages; Proteins; Vascular endothelial growth factor; Vascularization

Many patients of choroidal neovascularization (CNV) are unresponsive to the current anti-VEGF treatment. The mechanisms for anti-VEGF resistance are poorly understood. We explore the unique property of the apolipoprotein A-I (apoA-I) binding protein (AIBP) that enhances cholesterol efflux from endot...