Renal tubular epithelial cells: the neglected mediator of tubulointerstitial fibrosis after injury

• Published in: Cell death & disease Vol. 9; no. 11; pp. 1126 - 11
• Main Authors: Qi, Ruochen, Yang, Cheng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.11.2018; Springer Nature B.V
• Subjects: 631/250/256; 692/699/1585/104/1586; 96/21; Animals; Antibodies; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Communication - immunology; Cell Culture; Cytokines - genetics; Cytokines - immunology; Epithelial cells; Epithelial Cells - immunology; Epithelial Cells - pathology; Fibroblasts; Fibrosis; Gene Expression Regulation; Humans; Immunology; Inflammasomes - genetics; Inflammasomes - immunology; Kidney Tubules - immunology; Kidney Tubules - pathology; Life Sciences; Mitochondria - immunology; Mitochondria - pathology; Monocytes - immunology; Monocytes - pathology; Myofibroblasts - immunology; Myofibroblasts - pathology; Nephritis, Interstitial - genetics; Nephritis, Interstitial - immunology; Nephritis, Interstitial - pathology; NLR Family, Pyrin Domain-Containing 3 Protein - genetics; NLR Family, Pyrin Domain-Containing 3 Protein - immunology; Review; Review Article; Signal Transduction

Renal fibrosis, especially tubulointerstitial fibrosis, is the inevitable outcome of all progressive chronic kidney diseases (CKDs) and exerts a great health burden worldwide. For a long time, interests in renal fibrosis have been concentrated on fibroblasts and myofibroblasts. However, in recent ye...