Spatial transcriptomic survey of human embryonic cerebral cortex by single-cell RNA-seq analysis

• Published in: Cell research Vol. 28; no. 7; pp. 730 - 745
• Main Authors: Fan, Xiaoying, Dong, Ji, Zhong, Suijuan, Wei, Yuan, Wu, Qian, Yan, Liying, Yong, Jun, Sun, Le, Wang, Xiaoye, Zhao, Yangyu, Wang, Wei, Yan, Jie, Wang, Xiaoqun, Qiao, Jie, Tang, Fuchou
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2018; Nature Publishing Group
• Subjects: 38; 38/39; 38/77; 38/91; 631/136; 631/337; 82/51; Adults; Astrocytes; Biomedical and Life Sciences; Brain; Cell Biology; Cerebral cortex; Embryos; Gene expression; Genes; Gestation; Life Sciences; Maturation; Neurons; Pons; Regional development; Ribonucleic acid; RNA

The cellular complexity of human brain development has been intensively investigated, although a regional characterization of the entire human cerebral cortex based on single-cell transcriptome analysis has not been reported. Here, we performed RNA-seq on over 4,000 individual cells from 22 brain re...