The Glymphatic System: A Novel Therapeutic Target for Stroke Treatment

• Published in: Frontiers in aging neuroscience Vol. 13; p. 689098
• Main Authors: Lv, Tao, Zhao, Bing, Hu, Qin, Zhang, Xiaohua
• Format: Journal Article
• Language: English
• Published: Lausanne Frontiers Research Foundation 08.07.2021; Frontiers Media S.A
• Subjects: Alzheimer's disease; Apoptosis; AQP4; Aquaporin 4; Aquaporins; Astrocytes; Blood-brain barrier; Brain research; Cerebrospinal fluid; Cytokines; Edema; Epilepsy; glymphatic system; Headache; Hemorrhage; Hydrocephalus; Immune clearance; Inflammation; Lymphatic system; meningeal lymphatic system; Metabolism; Metabolites; Migraine; Nervous system; Neurodegenerative diseases; Neurological diseases; Neuroscience; Neurotoxicity; Pathophysiology; Physiology; Risk assessment; Solutes; Stroke; Therapeutic targets; Traumatic brain injury; Veins & arteries

The glymphatic system (GS) is a novel defined brain-wide perivascular transit network between cerebrospinal fluid (CSF) and interstitial solutes that facilitates the clearance of brain metabolic wastes. The complicated network of the GS consists of the periarterial CSF influx pathway, astrocytes-med...