Non-coding RNAs in hepatocellular carcinoma: molecular functions and pathological implications

• Published in: Nature reviews. Gastroenterology & hepatology Vol. 15; no. 3; pp. 137 - 151
• Main Authors: Wong, Chun-Ming, Tsang, Felice Ho-Ching, Ng, Irene Oi-Lin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2018; Nature Publishing Group
• Subjects: 631/337/176; 631/337/384; 631/337/384/331; 692/4020/4021/1607/1610; Biomedicine; Carcinogenesis; Care and treatment; Deoxyribonucleic acid; Development and progression; DNA; Gastroenterology; Gene expression; Gene regulation; Genetic aspects; Health aspects; Hepatocellular carcinoma; Hepatology; Hepatoma; Liver cancer; Malignancy; Medicine & Public Health; Mesenchyme; Metastases; MicroRNAs; miRNA; Molecular modelling; Next-generation sequencing; Oncogenes; Post-transcription; review-article; Therapeutic applications; Transcription activation; Tumors

Key Points Protein-coding sequence accounts for only 2% of the human genome, with the function of the remaining 98% of non-coding sequences in the human genome being largely elusive A large number of small and long non-coding RNAs (ncRNAs) have been identified, and deregulation of ncRNAs has a criti...