Non-coding RNAs in hepatocellular carcinoma: molecular functions and pathological implications

Key Points Protein-coding sequence accounts for only 2% of the human genome, with the function of the remaining 98% of non-coding sequences in the human genome being largely elusive A large number of small and long non-coding RNAs (ncRNAs) have been identified, and deregulation of ncRNAs has a criti...

Full description

Saved in:
Bibliographic Details
Published inNature reviews. Gastroenterology & hepatology Vol. 15; no. 3; pp. 137 - 151
Main Authors Wong, Chun-Ming, Tsang, Felice Ho-Ching, Ng, Irene Oi-Lin
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.03.2018
Nature Publishing Group
Subjects
631/337/176
631/337/384
631/337/384/331
692/4020/4021/1607/1610
Biomedicine
Carcinogenesis
Care and treatment
Deoxyribonucleic acid
Development and progression
DNA
Gastroenterology
Gene expression
Gene regulation
Genetic aspects
Health aspects
Hepatocellular carcinoma
Hepatology
Hepatoma
Liver cancer
Malignancy
Medicine & Public Health
Mesenchyme
Metastases
MicroRNAs
miRNA
Molecular modelling
Next-generation sequencing
Oncogenes
Post-transcription
review-article
Therapeutic applications
Transcription activation
Tumors
Online AccessGet full text

Cover

Abstract Key Points Protein-coding sequence accounts for only 2% of the human genome, with the function of the remaining 98% of non-coding sequences in the human genome being largely elusive A large number of small and long non-coding RNAs (ncRNAs) have been identified, and deregulation of ncRNAs has a critical role in liver carcinogenesis MicroRNAs negatively regulate gene expression at the post-transcriptional level; microRNAs can function as an 'oncomiRs' to repress tumour-suppressor genes or, vice versa, can act as a tumour suppressor to counteract oncogenes Long ncRNAs belong to functionally divergent groups of ncRNAs that regulate gene expression and other molecular functions through interacting with DNA, RNA and proteins Deregulation of ncRNAs profoundly contributes to liver carcinogenesis of diverse aetiologies, liver cancer stem cell formation, hepatocellular carcinoma epigenetic reprogramming and cancer metastasis Non-coding RNAs are potential molecular markers and therapeutic targets of human hepatocellular carcinoma A growing body of evidence implicates non-coding RNAs (ncRNAs) in liver carcinogenesis. In this Review, the authors summarize the pathological roles of ncRNAs in hepatocellular carcinoma and explore the potential applications of ncRNAs as diagnostic tools and therapeutic targets. Hepatocellular carcinoma (HCC) is a leading lethal malignancy worldwide. However, the molecular mechanisms underlying liver carcinogenesis remain poorly understood. Over the past two decades, overwhelming evidence has demonstrated the regulatory roles of different classes of non-coding RNAs (ncRNAs) in liver carcinogenesis related to a number of aetiologies, including HBV, HCV and NAFLD. Among the ncRNAs, microRNAs, which belong to a distinct class of small ncRNAs, have been proven to play a crucial role in the post-transcriptional regulation of gene expression. Deregulation of microRNAs has been broadly implicated in the inactivation of tumour-suppressor genes and activation of oncogenes in HCC. Modern high-throughput sequencing analyses have unprecedentedly identified a very large number of non-coding transcripts. Divergent groups of long ncRNAs have been implicated in liver carcinogenesis through interactions with DNA, RNA or proteins. Overall, ncRNAs represent a burgeoning field of cancer research, and we are only beginning to understand the importance and complicity of the ncRNAs in liver carcinogenesis. In this Review, we summarize the common deregulation of small and long ncRNAs in human HCC. We also comprehensively review the pathological roles of ncRNAs in liver carcinogenesis, epithelial-to-mesenchymal transition and HCC metastasis and discuss the potential applications of ncRNAs as diagnostic tools and therapeutic targets in human HCC.
AbstractList Hepatocellular carcinoma (HCC) is a leading lethal malignancy worldwide. However, the molecular mechanisms underlying liver carcinogenesis remain poorly understood. Over the past two decades, overwhelming evidence has demonstrated the regulatory roles of different classes of non-coding RNAs (ncRNAs) in liver carcinogenesis related to a number of aetiologies, including HBV, HCV and NAFLD. Among the ncRNAs, microRNAs, which belong to a distinct class of small ncRNAs, have been proven to play a crucial role in the post-transcriptional regulation of gene expression. Deregulation of microRNAs has been broadly implicated in the inactivation of tumour-suppressor genes and activation of oncogenes in HCC. Modern high-throughput sequencing analyses have unprecedentedly identified a very large number of non-coding transcripts. Divergent groups of long ncRNAs have been implicated in liver carcinogenesis through interactions with DNA, RNA or proteins. Overall, ncRNAs represent a burgeoning field of cancer research, and we are only beginning to understand the importance and complicity of the ncRNAs in liver carcinogenesis. In this Review, we summarize the common deregulation of small and long ncRNAs in human HCC. We also comprehensively review the pathological roles of ncRNAs in liver carcinogenesis, epithelial-to-mesenchymal transition and HCC metastasis and discuss the potential applications of ncRNAs as diagnostic tools and therapeutic targets in human HCC.
Hepatocellular carcinoma (HCC) is a leading lethal malignancy worldwide. However, the molecular mechanisms underlying liver carcinogenesis remain poorly understood. Over the past two decades, overwhelming evidence has demonstrated the regulatory roles of different classes of non-coding RNAs (ncRNAs) in liver carcinogenesis related to a number of aetiologies, including HBV, HCV and NAFLD. Among the ncRNAs, microRNAs, which belong to a distinct class of small ncRNAs, have been proven to play a crucial role in the post-transcriptional regulation of gene expression. Deregulation of microRNAs has been broadly implicated in the inactivation of tumour-suppressor genes and activation of oncogenes in HCC. Modern high-throughput sequencing analyses have unprecedentedly identified a very large number of non-coding transcripts. Divergent groups of long ncRNAs have been implicated in liver carcinogenesis through interactions with DNA, RNA or proteins. Overall, ncRNAs represent a burgeoning field of cancer research, and we are only beginning to understand the importance and complicity of the ncRNAs in liver carcinogenesis. In this Review, we summarize the common deregulation of small and long ncRNAs in human HCC. We also comprehensively review the pathological roles of ncRNAs in liver carcinogenesis, epithelial-to-mesenchymal transition and HCC metastasis and discuss the potential applications of ncRNAs as diagnostic tools and therapeutic targets in human HCC.Hepatocellular carcinoma (HCC) is a leading lethal malignancy worldwide. However, the molecular mechanisms underlying liver carcinogenesis remain poorly understood. Over the past two decades, overwhelming evidence has demonstrated the regulatory roles of different classes of non-coding RNAs (ncRNAs) in liver carcinogenesis related to a number of aetiologies, including HBV, HCV and NAFLD. Among the ncRNAs, microRNAs, which belong to a distinct class of small ncRNAs, have been proven to play a crucial role in the post-transcriptional regulation of gene expression. Deregulation of microRNAs has been broadly implicated in the inactivation of tumour-suppressor genes and activation of oncogenes in HCC. Modern high-throughput sequencing analyses have unprecedentedly identified a very large number of non-coding transcripts. Divergent groups of long ncRNAs have been implicated in liver carcinogenesis through interactions with DNA, RNA or proteins. Overall, ncRNAs represent a burgeoning field of cancer research, and we are only beginning to understand the importance and complicity of the ncRNAs in liver carcinogenesis. In this Review, we summarize the common deregulation of small and long ncRNAs in human HCC. We also comprehensively review the pathological roles of ncRNAs in liver carcinogenesis, epithelial-to-mesenchymal transition and HCC metastasis and discuss the potential applications of ncRNAs as diagnostic tools and therapeutic targets in human HCC.
Key Points Protein-coding sequence accounts for only 2% of the human genome, with the function of the remaining 98% of non-coding sequences in the human genome being largely elusive A large number of small and long non-coding RNAs (ncRNAs) have been identified, and deregulation of ncRNAs has a critical role in liver carcinogenesis MicroRNAs negatively regulate gene expression at the post-transcriptional level; microRNAs can function as an 'oncomiRs' to repress tumour-suppressor genes or, vice versa, can act as a tumour suppressor to counteract oncogenes Long ncRNAs belong to functionally divergent groups of ncRNAs that regulate gene expression and other molecular functions through interacting with DNA, RNA and proteins Deregulation of ncRNAs profoundly contributes to liver carcinogenesis of diverse aetiologies, liver cancer stem cell formation, hepatocellular carcinoma epigenetic reprogramming and cancer metastasis Non-coding RNAs are potential molecular markers and therapeutic targets of human hepatocellular carcinoma A growing body of evidence implicates non-coding RNAs (ncRNAs) in liver carcinogenesis. In this Review, the authors summarize the pathological roles of ncRNAs in hepatocellular carcinoma and explore the potential applications of ncRNAs as diagnostic tools and therapeutic targets. Hepatocellular carcinoma (HCC) is a leading lethal malignancy worldwide. However, the molecular mechanisms underlying liver carcinogenesis remain poorly understood. Over the past two decades, overwhelming evidence has demonstrated the regulatory roles of different classes of non-coding RNAs (ncRNAs) in liver carcinogenesis related to a number of aetiologies, including HBV, HCV and NAFLD. Among the ncRNAs, microRNAs, which belong to a distinct class of small ncRNAs, have been proven to play a crucial role in the post-transcriptional regulation of gene expression. Deregulation of microRNAs has been broadly implicated in the inactivation of tumour-suppressor genes and activation of oncogenes in HCC. Modern high-throughput sequencing analyses have unprecedentedly identified a very large number of non-coding transcripts. Divergent groups of long ncRNAs have been implicated in liver carcinogenesis through interactions with DNA, RNA or proteins. Overall, ncRNAs represent a burgeoning field of cancer research, and we are only beginning to understand the importance and complicity of the ncRNAs in liver carcinogenesis. In this Review, we summarize the common deregulation of small and long ncRNAs in human HCC. We also comprehensively review the pathological roles of ncRNAs in liver carcinogenesis, epithelial-to-mesenchymal transition and HCC metastasis and discuss the potential applications of ncRNAs as diagnostic tools and therapeutic targets in human HCC.
Audience Academic
Author Tsang, Felice Ho-Ching
Ng, Irene Oi-Lin
Wong, Chun-Ming
Author_xml – sequence: 1
  givenname: Chun-Ming
  surname: Wong
  fullname: Wong, Chun-Ming
  organization: Department of Pathology, The University of Hong Kong, Block T, Queen Mary Hospital, State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong Jockey Club Building for Interdisciplinary Research, Hong Kong
– sequence: 2
  givenname: Felice Ho-Ching
  surname: Tsang
  fullname: Tsang, Felice Ho-Ching
  organization: Department of Pathology, The University of Hong Kong, Block T, Queen Mary Hospital, State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong Jockey Club Building for Interdisciplinary Research, Hong Kong
– sequence: 3
  givenname: Irene Oi-Lin
  surname: Ng
  fullname: Ng, Irene Oi-Lin
  email: iolng@hku.hk
  organization: Department of Pathology, The University of Hong Kong, Block T, Queen Mary Hospital, State Key Laboratory for Liver Research, The University of Hong Kong, Hong Kong Jockey Club Building for Interdisciplinary Research, Hong Kong
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29317776$$D View this record in MEDLINE/PubMed
BookMark eNp9kktv3CAQx1GVqHn1A_RSWapU9eItD2NMb6uoj0hRKlXptWgWsJcIwxbsQ7592d08mqitOICG33_4MzMn6CDEYBF6TfCCYNZ9CGmAPKW4oJiIBWnlC3RMBJc1x5wdPJwbfoROcr7BuOWcyZfoiEpGhBDtMfp5FUOto3FhqL5fLXPlQrW2G5iitt7PHlKlIWkX4ggfqzF6q3fBfg56cjHkCoKpCr-OPg5Og6_cuPHlsLs9Q4c9-Gxf3e2n6MfnT9fnX-vLb18uzpeXteasnWrdEioECIqxEc1KNi2nnemI0YQaQS3jq0Za4AQ6TVuNDTbQ2J5h3PSmA8xO0ft93k2Kv2abJzW6vP0BBBvnrIjsJOccE1bQt8_QmzinUNwpiiljXcMpf6QG8Fa50Mcpgd4mVcvijXPBpCjU4i9UWcaOTpdm9a7Enwje_SFYW_DTOkc_74r1FHxz53JejdaoTXIjpFt137kCkD2gU8w52f4BIVhtp0PdT4faTocq01E04plGu2nXqGLb-f8q6V6ZyythsOmxaP8W_Qb2CNC-
CitedBy_id crossref_primary_10_1016_j_virs_2023_10_002
crossref_primary_10_1042_BSR20192790
crossref_primary_10_2147_IJGM_S340629
crossref_primary_10_3390_cancers13091996
crossref_primary_10_1016_j_biopha_2018_07_155
crossref_primary_10_2147_JHC_S510581
crossref_primary_10_3389_fendo_2023_1156494
crossref_primary_10_1007_s10565_021_09650_9
crossref_primary_10_7717_peerj_16566
crossref_primary_10_3389_fgene_2021_739975
crossref_primary_10_1038_s41598_023_42317_5
crossref_primary_10_18632_aging_204059
crossref_primary_10_4254_wjh_v13_i9_1107
crossref_primary_10_2147_JHC_S285726
crossref_primary_10_1111_cas_15697
crossref_primary_10_1007_s00335_022_09945_0
crossref_primary_10_1016_j_prp_2018_09_022
crossref_primary_10_1128_JVI_00507_18
crossref_primary_10_1590_1678_4324_2022210652
crossref_primary_10_3349_ymj_2018_59_10_1181
crossref_primary_10_3390_genes14030550
crossref_primary_10_3390_ijms21062255
crossref_primary_10_3892_or_2022_8346
crossref_primary_10_3390_ijms23073695
crossref_primary_10_1111_jcmm_13987
crossref_primary_10_3389_fphys_2019_00279
crossref_primary_10_1007_s10735_023_10157_2
crossref_primary_10_3349_ymj_2018_59_7_816
crossref_primary_10_3390_diagnostics13172794
crossref_primary_10_1016_j_cbi_2020_109055
crossref_primary_10_1002_advs_202306810
crossref_primary_10_1016_j_semcancer_2021_07_017
crossref_primary_10_1038_s41419_019_2089_9
crossref_primary_10_1002_lt_25731
crossref_primary_10_1016_j_dld_2022_04_015
crossref_primary_10_3389_fcell_2021_710207
crossref_primary_10_1186_s12967_024_05233_4
crossref_primary_10_1007_s11427_023_2527_5
crossref_primary_10_1016_j_omtn_2020_09_003
crossref_primary_10_1155_2022_1971559
crossref_primary_10_3390_cancers12092622
crossref_primary_10_1016_j_gendis_2020_11_014
crossref_primary_10_1186_s11658_023_00447_8
crossref_primary_10_1016_j_prp_2023_154403
crossref_primary_10_2217_bmm_2020_0795
crossref_primary_10_1038_s41419_019_2188_7
crossref_primary_10_1186_s13046_022_02297_2
crossref_primary_10_32604_biocell_2022_016962
crossref_primary_10_3389_fonc_2024_1415801
crossref_primary_10_1002_jcb_29656
crossref_primary_10_1038_s41392_021_00781_3
crossref_primary_10_3390_pharmaceutics14010041
crossref_primary_10_1016_j_biopha_2018_10_105
crossref_primary_10_1111_jcmm_14361
crossref_primary_10_3390_pharmaceutics15041249
crossref_primary_10_1186_s13046_021_01968_w
crossref_primary_10_3390_biom15010144
crossref_primary_10_1186_s13046_022_02433_y
crossref_primary_10_1021_acs_jproteome_4c00862
crossref_primary_10_1002_hep_31448
crossref_primary_10_1016_j_heliyon_2024_e30066
crossref_primary_10_3389_fgene_2022_984743
crossref_primary_10_3390_livers2030017
crossref_primary_10_3389_fphar_2023_1270425
crossref_primary_10_7717_peerj_13708
crossref_primary_10_1002_jcp_28958
crossref_primary_10_1186_s12943_023_01801_2
crossref_primary_10_1016_j_micron_2022_103283
crossref_primary_10_1515_biol_2022_0936
crossref_primary_10_1016_j_biopha_2019_109386
crossref_primary_10_1038_s41388_021_01671_2
crossref_primary_10_3390_cells11081267
crossref_primary_10_1080_15384101_2021_2016196
crossref_primary_10_1016_j_intimp_2024_112297
crossref_primary_10_1016_j_omto_2021_12_001
crossref_primary_10_3389_fcimb_2021_714895
crossref_primary_10_3389_fgene_2021_741608
crossref_primary_10_3389_fonc_2022_831366
crossref_primary_10_3389_fonc_2021_696705
crossref_primary_10_3389_fcell_2021_751578
crossref_primary_10_3390_v10110591
crossref_primary_10_3389_fimmu_2023_1141956
crossref_primary_10_3390_diagnostics12051133
crossref_primary_10_3390_ijms22094997
crossref_primary_10_1093_abbs_gmaa029
crossref_primary_10_1186_s12935_019_0909_8
crossref_primary_10_3390_cancers12051290
crossref_primary_10_1155_2021_8837811
crossref_primary_10_3389_fcell_2023_1164301
crossref_primary_10_1002_ijc_33111
crossref_primary_10_1002_1878_0261_12424
crossref_primary_10_1016_j_biopha_2019_109703
crossref_primary_10_3389_fonc_2023_1249198
crossref_primary_10_15252_embr_201847052
crossref_primary_10_1016_j_genrep_2021_101103
crossref_primary_10_2147_PGPM_S431346
crossref_primary_10_1080_1040841X_2024_2339260
crossref_primary_10_1016_j_yexcr_2019_111649
crossref_primary_10_1186_s12935_021_02351_7
crossref_primary_10_1038_s41419_023_05831_y
crossref_primary_10_1177_03008916211072585
crossref_primary_10_1186_s12906_021_03365_4
crossref_primary_10_1080_21655979_2021_1930336
crossref_primary_10_1039_C8RA07055E
crossref_primary_10_1155_2022_8002318
crossref_primary_10_3892_mmr_2020_11519
crossref_primary_10_1007_s10528_024_10944_w
crossref_primary_10_1186_s12935_021_01835_w
crossref_primary_10_3389_fmolb_2021_784553
crossref_primary_10_1016_j_csbj_2020_09_001
crossref_primary_10_1111_cpr_12966
crossref_primary_10_1016_j_bbcan_2021_188519
crossref_primary_10_1002_cac2_12117
crossref_primary_10_1016_j_cellsig_2024_111076
crossref_primary_10_1038_s41392_023_01341_7
crossref_primary_10_1016_j_ajpath_2019_10_010
crossref_primary_10_1097_MD_0000000000037486
crossref_primary_10_1016_j_cmet_2019_07_011
crossref_primary_10_1016_j_mvr_2020_104120
crossref_primary_10_1016_j_gene_2020_144724
crossref_primary_10_2147_OTT_S254455
crossref_primary_10_1016_j_biopha_2018_06_135
crossref_primary_10_3390_genes13020282
crossref_primary_10_1186_s13046_020_01576_0
crossref_primary_10_1080_21655979_2021_1994719
crossref_primary_10_3389_fonc_2020_553714
crossref_primary_10_3390_ncrna7010010
crossref_primary_10_3389_fonc_2022_1008856
crossref_primary_10_1007_s10528_022_10273_w
crossref_primary_10_1016_j_prp_2022_154245
crossref_primary_10_3390_biom9110718
crossref_primary_10_1080_16078454_2022_2046326
crossref_primary_10_1111_jcmm_17558
crossref_primary_10_3390_cancers15072088
crossref_primary_10_7717_peerj_8252
crossref_primary_10_1371_journal_pone_0266966
crossref_primary_10_3390_cancers15215178
crossref_primary_10_1002_mco2_125
crossref_primary_10_1016_j_jbc_2022_101983
crossref_primary_10_3390_ijms24054286
crossref_primary_10_1002_ctm2_1107
crossref_primary_10_17235_reed_2021_8139_2021
crossref_primary_10_3390_genes14010013
crossref_primary_10_1080_21655979_2022_2065951
crossref_primary_10_1186_s12943_020_01188_4
crossref_primary_10_1155_2022_1125932
crossref_primary_10_1080_15384101_2018_1526599
crossref_primary_10_3390_cancers11111652
crossref_primary_10_1155_2022_4694323
crossref_primary_10_3389_fimmu_2018_02801
crossref_primary_10_1016_j_biopha_2020_111212
crossref_primary_10_3389_fphar_2021_708967
crossref_primary_10_3390_ijms20215266
crossref_primary_10_1007_s00018_021_03929_0
crossref_primary_10_1111_liv_15026
crossref_primary_10_3390_bioengineering9080406
crossref_primary_10_1016_j_abb_2025_110306
crossref_primary_10_4251_wjgo_v13_i4_197
crossref_primary_10_1016_j_ijbiomac_2024_135131
crossref_primary_10_3390_ijms22020632
crossref_primary_10_1038_s41419_018_0937_7
crossref_primary_10_1136_gutjnl_2021_325109
crossref_primary_10_1016_j_cca_2019_02_001
crossref_primary_10_1016_j_omtn_2020_03_014
crossref_primary_10_1038_s41420_024_02285_9
crossref_primary_10_3390_bios11110425
crossref_primary_10_3748_wjg_v31_i3_95207
crossref_primary_10_3390_cancers14143410
crossref_primary_10_5812_ijcm_157228
crossref_primary_10_1186_s12935_020_01407_4
crossref_primary_10_1002_advs_202103135
crossref_primary_10_3389_fgene_2021_693259
crossref_primary_10_1186_s12885_020_07625_3
crossref_primary_10_15212_bioi_2021_0002
crossref_primary_10_3389_fgene_2022_972212
crossref_primary_10_1155_2021_7020637
crossref_primary_10_1016_j_lfs_2020_118933
crossref_primary_10_1016_j_semcancer_2020_07_003
crossref_primary_10_1038_s41413_023_00289_2
crossref_primary_10_1002_hep_30613
crossref_primary_10_1097_MD_0000000000033990
crossref_primary_10_1152_ajpcell_00510_2018
crossref_primary_10_1007_s00277_023_05383_3
crossref_primary_10_1080_2162402X_2018_1503913
crossref_primary_10_1039_C8RA01200H
crossref_primary_10_18632_aging_104162
crossref_primary_10_1515_hsz_2020_0130
crossref_primary_10_1016_j_canlet_2018_08_024
crossref_primary_10_3389_fonc_2023_1230164
crossref_primary_10_1007_s00432_020_03224_8
crossref_primary_10_1097_MD_0000000000026762
crossref_primary_10_1111_jcmm_16859
crossref_primary_10_3390_ijms22063137
crossref_primary_10_1177_1533033819878686
crossref_primary_10_2174_1389450120666190307095720
crossref_primary_10_1161_CIRCRESAHA_119_316337
crossref_primary_10_1007_s11684_022_0966_6
crossref_primary_10_3892_ijo_2022_5336
crossref_primary_10_3389_fonc_2024_1255061
crossref_primary_10_1016_j_bbrep_2024_101695
crossref_primary_10_1038_s41392_023_01480_x
crossref_primary_10_1007_s13402_020_00540_6
crossref_primary_10_3892_mmr_2018_9734
crossref_primary_10_1007_s00432_020_03378_5
crossref_primary_10_1089_cmb_2019_0250
crossref_primary_10_1371_journal_pone_0232211
crossref_primary_10_3389_fgene_2022_1028477
crossref_primary_10_1016_j_ejphar_2019_01_049
crossref_primary_10_1155_2019_5604843
crossref_primary_10_1155_2020_2383516
crossref_primary_10_1186_s13046_022_02488_x
crossref_primary_10_3389_fcell_2021_711815
crossref_primary_10_1016_j_clinthera_2020_01_012
crossref_primary_10_3389_fgene_2022_931928
crossref_primary_10_3389_fmolb_2021_759173
crossref_primary_10_1371_journal_pone_0301663
crossref_primary_10_1016_j_gene_2023_147747
crossref_primary_10_3389_fonc_2021_583714
crossref_primary_10_3389_fonc_2021_743990
crossref_primary_10_1016_j_clinre_2021_101648
crossref_primary_10_1016_j_trac_2020_115965
crossref_primary_10_3389_fonc_2022_907399
crossref_primary_10_3389_fphar_2023_1177405
crossref_primary_10_1186_s13027_024_00618_y
crossref_primary_10_1007_s11901_019_00491_z
crossref_primary_10_3390_ijms222212359
crossref_primary_10_1016_j_prp_2019_152680
crossref_primary_10_1038_s41419_022_05348_w
crossref_primary_10_3748_wjg_v27_i20_2586
crossref_primary_10_2147_IJGM_S354842
crossref_primary_10_12701_jyms_2023_01186
crossref_primary_10_1016_j_ijbiomac_2023_125863
crossref_primary_10_1016_j_omtn_2019_08_020
crossref_primary_10_1016_j_micpath_2023_105995
crossref_primary_10_1155_2019_1684039
crossref_primary_10_3389_fonc_2020_597996
crossref_primary_10_1016_j_ejphar_2019_172589
crossref_primary_10_1515_hmbci_2019_0044
crossref_primary_10_1016_j_ymthe_2024_08_001
crossref_primary_10_2217_bmm_2020_0825
crossref_primary_10_1111_jcmm_17126
crossref_primary_10_3389_fcell_2021_631931
crossref_primary_10_1016_j_canlet_2021_03_025
crossref_primary_10_1111_jcmm_15186
crossref_primary_10_3389_fonc_2021_671144
crossref_primary_10_3389_fonc_2021_729340
crossref_primary_10_1089_cbr_2019_3335
crossref_primary_10_3389_fcell_2021_746714
crossref_primary_10_1096_fj_202002374R
crossref_primary_10_1002_ijc_34040
crossref_primary_10_1186_s12885_022_09662_6
crossref_primary_10_3389_fgene_2024_1440430
crossref_primary_10_3390_ijms24108886
crossref_primary_10_3389_fgene_2023_1249171
crossref_primary_10_32604_Oncologie_2021_016900
crossref_primary_10_1007_s10238_024_01296_1
crossref_primary_10_1186_s12864_021_07478_5
crossref_primary_10_3233_CBM_230143
crossref_primary_10_1155_2023_7057236
crossref_primary_10_2174_0929867329666220222113707
crossref_primary_10_1016_j_omtn_2020_05_011
crossref_primary_10_3390_ijms231911908
crossref_primary_10_3390_jcm10081715
crossref_primary_10_32604_biocell_2022_023568
crossref_primary_10_1128_mbio_00127_25
crossref_primary_10_1186_s12885_021_08704_9
crossref_primary_10_3389_fgene_2022_942454
crossref_primary_10_1002_cnr2_70049
crossref_primary_10_18632_aging_103552
crossref_primary_10_1016_j_tranon_2020_100974
crossref_primary_10_1038_s41598_019_56571_z
crossref_primary_10_61186_rbmb_13_1_59
crossref_primary_10_1186_s13045_018_0579_3
crossref_primary_10_3389_fcell_2021_778582
crossref_primary_10_1002_2211_5463_12724
crossref_primary_10_1002_jcb_28315
crossref_primary_10_3389_fonc_2022_1056897
crossref_primary_10_1186_s12885_022_09530_3
crossref_primary_10_1177_1533033820985787
crossref_primary_10_1016_j_cmet_2020_01_002
crossref_primary_10_3389_fcell_2021_781867
crossref_primary_10_1007_s10637_018_0624_7
crossref_primary_10_1016_j_canlet_2020_02_003
crossref_primary_10_1016_j_heliyon_2023_e19862
crossref_primary_10_3389_fonc_2021_784067
crossref_primary_10_1111_prd_12427
crossref_primary_10_3390_cancers15164187
crossref_primary_10_1016_j_biopha_2020_111169
crossref_primary_10_3389_fcell_2021_735855
crossref_primary_10_1016_j_bbrc_2018_08_047
crossref_primary_10_1039_D1MO00138H
crossref_primary_10_1080_21655979_2022_2067292
crossref_primary_10_1038_s41419_021_03453_w
crossref_primary_10_1080_1354750X_2020_1854856
crossref_primary_10_1111_1440_1681_13218
crossref_primary_10_3390_ijms22158346
crossref_primary_10_1128_jvi_00207_22
crossref_primary_10_1038_s41419_021_03854_x
crossref_primary_10_2147_JHC_S303330
crossref_primary_10_1038_s41419_020_03031_6
crossref_primary_10_3390_life14111430
crossref_primary_10_1186_s12876_022_02540_2
crossref_primary_10_1007_s13273_021_00185_y
crossref_primary_10_1007_s10904_023_02843_1
crossref_primary_10_1016_j_biopha_2019_109343
crossref_primary_10_1038_s41388_020_01630_3
crossref_primary_10_3390_cancers15164057
crossref_primary_10_3390_ijms221910774
crossref_primary_10_3389_fphys_2022_903302
crossref_primary_10_3390_ijms21145068
crossref_primary_10_1039_C8RA09229J
crossref_primary_10_1186_s12935_021_02049_w
crossref_primary_10_1038_s41467_025_57367_8
crossref_primary_10_3389_fonc_2022_790916
crossref_primary_10_1016_j_jcmgh_2022_07_017
crossref_primary_10_1186_s13045_019_0839_x
crossref_primary_10_3390_cancers10080258
crossref_primary_10_3390_ijms19041007
crossref_primary_10_1016_j_intimp_2024_112807
Cites_doi 10.1038/bjc.2011.190
10.1038/nsmb.3235
10.1126/science.1102513
10.1136/gutjnl-2014-306996
10.1111/j.1478-3231.2011.02750.x
10.1002/hep.28123
10.1101/gad.209841.112
10.1158/0008-5472.CAN-10-1001
10.1101/gad.1640608
10.1053/j.gastro.2008.12.004
10.1016/j.stem.2010.11.010
10.1111/febs.13839
10.1002/hep.27929
10.1016/j.jhep.2011.11.026
10.1002/hep.28304
10.1038/35102167
10.1111/liv.12746
10.1158/0008-5472.CAN-08-2886
10.1038/srep35531
10.1038/35053110
10.18632/oncotarget.3700
10.1016/j.bbrc.2016.04.054
10.1038/nrm3838
10.1053/j.gastro.2010.10.006
10.1111/liv.12517
10.1158/0008-5472.CAN-08-4797
10.1158/0008-5472.CAN-11-1144
10.18632/oncotarget.12465
10.1016/j.ccr.2014.01.030
10.1093/carcin/bgs381
10.1002/hep.25747
10.1016/j.jhep.2016.01.019
10.2741/E595
10.1038/nrg.2016.59
10.1371/journal.pgen.1004873
10.1158/1078-0432.CCR-09-0092
10.1038/srep23521
10.1038/nature08975
10.1038/nature04303
10.1016/j.canlet.2014.03.029
10.1016/j.jhep.2013.05.045
10.1016/j.stem.2015.03.003
10.1002/hep.24675
10.1136/gut.2011.239145
10.1038/nrc3195
10.1038/onc.2008.178
10.1016/0092-8674(82)90414-7
10.1053/j.gastro.2007.05.022
10.1136/gutjnl-2013-305715
10.1016/j.tig.2016.03.002
10.1186/1476-4598-13-216
10.1016/j.bbrc.2011.01.111
10.1002/jcb.20982
10.1002/hep.23904
10.1002/hep.26095
10.1016/j.cell.2009.04.021
10.1016/j.cell.2007.01.043
10.1038/srep37982
10.1101/gr.132159.111
10.1002/ijc.21731
10.1016/j.cmet.2015.02.004
10.1371/journal.pone.0030733
10.1038/nature06205
10.1053/j.gastro.2007.04.025
10.1016/j.jhep.2010.09.023
10.1371/journal.pone.0158347
10.1172/JCI84424
10.1158/1078-0432.CCR-09-1840
10.1146/annurev.arplant.57.032905.105218
10.1126/science.1178178
10.1093/jmcb/mjx043
10.1371/journal.pone.0115036
10.1016/j.cell.2007.05.022
10.1038/onc.2015.223
10.1074/jbc.M112.342113
10.1002/hep.27816
10.1016/j.trsl.2015.10.002
10.18632/oncotarget.6280
10.18632/oncotarget.5667
10.1038/ncomms8466
10.1038/ncomms13608
10.1177/030089160509100306
10.1002/hep.26195
10.1002/hep.26422
10.1016/j.cell.2008.06.052
10.1093/nar/gkr1012
10.1146/annurev.bi.64.070195.004341
10.1158/0008-5472.CAN-10-0145
10.1002/hep.26369
10.1016/j.jhep.2013.01.032
10.1016/j.jhep.2015.09.013
10.1073/pnas.1213515110
10.1038/nature06783
10.1038/351329a0
10.1002/hep.22749
10.1158/0008-5472.CAN-12-2850
10.1158/0008-5472.CAN-06-4607
10.1038/nature11928
10.1084/jem.20120153
10.1038/nature09819
10.1158/0008-5472.CAN-14-3721
10.1016/j.biomaterials.2014.12.023
10.1016/j.jhep.2016.02.005
10.18632/oncotarget.10567
10.1073/pnas.74.8.3171
10.1038/ncomms14421
10.1016/S0022-2836(66)80009-8
10.1093/nar/gkv1367
10.1038/nrgastro.2013.149
10.1002/hep.24577
10.1038/sj.onc.1209283
10.1016/j.cell.2015.02.025
10.18632/oncotarget.7740
10.1016/j.jhep.2008.06.010
10.1038/onc.2013.369
10.1002/hep.23660
10.1136/gutjnl-2016-312869
10.1038/nature01957
10.1038/nrg.2015.10
10.1158/0008-5472.CAN-14-1192
10.1126/science.1113329
10.1002/hep.28679
10.15252/embj.201591803
10.1002/hep.26083
10.1007/s00109-016-1442-z
10.1016/0092-8674(93)90529-Y
10.1093/nar/gkt1181
10.1002/hep.28445
10.1158/0008-5472.CAN-11-1021
10.1016/j.ccr.2012.07.023
10.1186/s12943-015-0431-0
10.1002/hep.27886
10.1158/1078-0432.CCR-16-1464
10.1002/hep.22569
10.1093/carcin/bgt139
10.1016/j.jhep.2009.12.043
10.1111/j.1478-3231.2007.01637.x
10.1053/j.gastro.2012.04.007
10.1038/onc.2009.211
10.1172/JCI63539
10.1172/JCI63455
10.1002/hep.25512
10.1016/j.ejca.2014.07.008
10.1073/pnas.0907904107
10.1245/s10434-011-1581-y
10.1038/nrg3965
10.1038/onc.2013.309
10.1200/JCO.2011.38.2697
10.1016/j.jhep.2015.05.016
10.4161/rna.18827
10.1038/nrg3722
10.1016/j.biopha.2016.11.035
10.1158/1078-0432.CCR-07-0523
10.1073/pnas.1220841110
10.1073/pnas.1112263109
10.1073/pnas.1012464108
10.1371/journal.pbio.0020098
10.1186/s13045-015-0153-1
10.3322/caac.20107
10.1002/hep.29034
10.1002/hep.26740
10.1158/0008-5472.CAN-07-6655
10.1016/j.jhep.2016.12.010
10.1053/j.gastro.2006.08.026
10.1016/j.ccr.2014.03.010
10.18632/oncotarget.9429
10.18632/oncotarget.2934
10.1056/NEJMoa1209026
10.1002/hep.25679
10.18632/oncotarget.3290
10.1002/hep.25849
10.1038/nrgastro.2013.183
10.1371/journal.pone.0101330
10.18632/oncotarget.12304
10.3109/23324015.2015.1077591
10.1038/nature09144
10.1002/hep.24563
10.1128/MCB.10.1.28
10.1016/j.ccr.2011.01.001
10.1038/embor.2008.74
10.1261/rna.035667.112
10.18632/oncotarget.6087
10.1038/ncb2039
10.1111/hepr.12606
10.1038/nrm3089
10.1002/hep.26712
10.1016/j.ccr.2009.10.014
10.1111/cas.12126
ContentType Journal Article
Copyright Springer Nature Limited 2018
COPYRIGHT 2018 Nature Publishing Group
Copyright Nature Publishing Group Mar 2018
Copyright_xml – notice: Springer Nature Limited 2018
– notice: COPYRIGHT 2018 Nature Publishing Group
– notice: Copyright Nature Publishing Group Mar 2018
DBID AAYXX
CITATION
NPM
3V.
7X7
7XB
88E
8FE
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M7P
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
7X8
DOI 10.1038/nrgastro.2017.169
DatabaseName CrossRef
PubMed
ProQuest Central (Corporate)
ProQuest Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni)
Medical Database
Biological Science Database
ProQuest Central Premium
ProQuest One Academic
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
DatabaseTitle CrossRef
PubMed
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList PubMed
MEDLINE - Academic



ProQuest Central Student
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1759-5053
EndPage 151
ExternalDocumentID A528557397
29317776
10_1038_nrgastro_2017_169
Genre Research Support, Non-U.S. Gov't
Journal Article
Review
GroupedDBID ---
0R~
29M
39C
3V.
53G
70F
7X7
88E
8FE
8FH
8FI
8FJ
AAEEF
AAQQT
AARCD
AASDW
AAWTL
AAWYQ
AAYZH
AAZLF
ABAWZ
ABJNI
ABLJU
ABUWG
ACGFS
ADBBV
AENEX
AFKRA
AFSHS
AGAYW
AGHTU
AHBCP
AHMBA
AHOSX
AHSBF
AIBTJ
ALFFA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
ARMCB
AXYYD
BBNVY
BENPR
BHPHI
BKKNO
BPHCQ
BVXVI
CCPQU
DB5
EBS
EE.
EJD
EXGXG
F5P
FQGFK
FSGXE
FYUFA
HCIFZ
HMCUK
HZ~
IAO
IHR
IHW
INH
INR
ITC
LK8
M1P
M7P
NNMJJ
ODYON
OVD
PQQKQ
PROAC
PSQYO
RNR
RNT
RNTTT
SHXYY
SIXXV
SNYQT
SOJ
TAOOD
TBHMF
TDRGL
TEORI
TSG
UKHRP
AAYXX
AFANA
ALPWD
ATHPR
CITATION
PHGZM
PHGZT
NFIDA
NPM
PMFND
7XB
8FK
AZQEC
DWQXO
GNUQQ
K9.
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQUKI
PRINS
7X8
ID FETCH-LOGICAL-c536t-c61277a7200d74b946528d81dc12d72e35b49ea51a8c26c0d0da4ef3004fd8a03
IEDL.DBID 7X7
ISSN 1759-5045
1759-5053
IngestDate Fri Jul 11 01:43:53 EDT 2025
Thu Jul 17 02:02:53 EDT 2025
Tue Jun 17 21:59:16 EDT 2025
Tue Jun 10 20:53:01 EDT 2025
Thu May 22 21:23:27 EDT 2025
Thu Apr 03 06:58:36 EDT 2025
Tue Jul 01 00:22:46 EDT 2025
Thu Apr 24 22:50:21 EDT 2025
Fri Feb 21 02:37:06 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 3
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c536t-c61277a7200d74b946528d81dc12d72e35b49ea51a8c26c0d0da4ef3004fd8a03
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
PMID 29317776
PQID 2023384525
PQPubID 2042741
PageCount 15
ParticipantIDs proquest_miscellaneous_1989555013
proquest_journals_2023384525
gale_infotracmisc_A528557397
gale_infotracacademiconefile_A528557397
gale_healthsolutions_A528557397
pubmed_primary_29317776
crossref_primary_10_1038_nrgastro_2017_169
crossref_citationtrail_10_1038_nrgastro_2017_169
springer_journals_10_1038_nrgastro_2017_169
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2018-03-01
PublicationDateYYYYMMDD 2018-03-01
PublicationDate_xml – month: 03
  year: 2018
  text: 2018-03-01
  day: 01
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature reviews. Gastroenterology & hepatology
PublicationTitleAbbrev Nat Rev Gastroenterol Hepatol
PublicationTitleAlternate Nat Rev Gastroenterol Hepatol
PublicationYear 2018
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References Tang (CR170) 2015; 6
Rinn (CR50) 2007; 129
Cheung (CR118) 2008; 48
Lee (CR191) 2003; 425
Lanford (CR176) 2010; 327
Kota (CR178) 2009; 137
Jeck (CR60) 2013; 19
Derrien (CR7) 2012; 22
Hutvagner, Simard, Mello, Zamore (CR173) 2004; 2
Williams, Farzaneh (CR29) 2012; 12
Siomi, Sato, Pezic, Aravin (CR32) 2011; 12
Dou (CR65) 2016; 6
Panzitt (CR43) 2007; 132
Younossi (CR2) 2015; 62
Tang (CR182) 2016; 7
Li (CR98) 2014; 50
Coulouarn, Factor, Andersen, Durkin, Thorgeirsson (CR75) 2009; 28
Quinn, Chang (CR35) 2016; 17
Morris, Mattick (CR151) 2014; 15
CR166
CR167
CR165
Peng (CR67) 2015; 6
Beg (CR181) 2015
Ward, McEwan, Mills, Janitz (CR36) 2015; 1
Wang (CR79) 2014; 9
Guo (CR84) 2015; 62
Ma (CR146) 2010; 7
Salzman (CR59) 2016; 32
Liu (CR57) 2016; 473
Brockdorff (CR194) 1991; 351
Kutay (CR74) 2006; 99
Wang (CR52) 2011; 472
Wong (CR77) 2014; 9
Warner, Soeiro, Birnboim, Girard, Darnell (CR185) 1966; 19
Yamashita (CR145) 2009; 136
Yu (CR63) 2016; 11
Sehgal, Vaishnaw, Fitzgerald (CR172) 2013; 59
Crick (CR5) 1958; 12
Simerzin (CR81) 2016; 64
Wong (CR23) 2012; 55
Borel, Konstantinova, Jansen (CR26) 2012; 56
Chuang (CR154) 2015; 62
Gao (CR22) 2011; 54
Liang (CR104) 2016; 64
Fornari (CR86) 2008; 27
Li (CR73) 2016; 7
Tsai (CR120) 2012; 122
Yuan (CR56) 2014; 349
Huang (CR102) 2013; 57
Berget, Moore, Sharp (CR186) 1977; 74
Wang (CR40) 2015; 16
Williams (CR196) 2008; 134
Wong (CR17) 2010; 16
Xu (CR121) 2015; 6
Jopling, Yi, Lancaster, Lemon, Sarnow (CR108) 2005; 309
Kogo (CR48) 2011; 71
Wong, Kai, Tsang, Ng (CR24) 2013; 5
Zhou (CR139) 2016; 63
Shimakami (CR106) 2012; 109
Zhang (CR114) 2012; 56
Ding (CR128) 2010; 12
Elmen (CR174) 2008; 452
Zhou (CR164) 2011; 29
Ha, Kim (CR10) 2014; 15
Rizzo (CR33) 2016; 7
Xu (CR97) 2013; 123
Huang (CR159) 2015; 8
Zhu (CR42) 2016; 23
Wree, Broderick, Canbay, Hoffman, Feldstein (CR116) 2013; 10
Jopling (CR70) 2012; 9
Michelotti, Machado, Diehl (CR117) 2013; 10
Pirola (CR119) 2015; 64
Ma (CR144) 2007; 132
CR122
Xie, Ma, Zhou (CR168) 2013; 2013
Li (CR163) 2010; 70
Chiu (CR94) 2016; 64
Garcia-Sastre, Evans (CR109) 2013; 110
Enuka (CR64) 2016; 44
Adams, Parsons, Walker, Zhang, Slack (CR184) 2017; 127
Xia, Ooi, Hui (CR133) 2013; 58
Wang (CR76) 2014; 59
Fornari (CR91) 2017; 23
Lau (CR103) 2014; 25
Zhu (CR41) 2016; 7
Wang (CR21) 2010; 53
Jemal (CR1) 2011; 61
Chen (CR68) 2015; 44
Rosenbloom (CR6) 2012; 40
Pedersen (CR113) 2007; 449
Giordano, Columbano (CR25) 2013; 57
Li (CR148) 2015; 64
Yang (CR138) 2012; 22
Park (CR175) 2011; 71
Kamel (CR169) 2016; 168
Lee, Feinbaum, Ambros (CR189) 1993; 75
Burk (CR136) 2008; 9
Fornari (CR83) 2010; 70
Gramantieri (CR18) 2007; 67
Liang (CR19) 2010; 52
Wang (CR69) 2013; 34
Huang (CR99) 2015; 6
Callegari (CR90) 2012; 56
Hou (CR82) 2011; 19
Huang (CR162) 2015; 14
Law (CR34) 2013; 58
Cui (CR46) 2015; 75
Reya, Morrison, Clarke, Weissman (CR143) 2001; 414
Gramantieri (CR87) 2009; 15
Wong (CR155) 2016; 63
Fan (CR156) 2013; 57
Dhanasekaran, Limaye, Cabrera (CR3) 2012; 4
Li, Masaki, Yamane, McGivern, Lemon (CR107) 2013; 110
Fang (CR131) 2011; 54
Xu (CR80) 2012; 32
Jonas, Izaurralde (CR8) 2015; 16
Zhang (CR142) 2013; 34
Pineau (CR16) 2010; 107
Zheng (CR126) 2012; 61
Li, Wang, Yu, Chen, Luo (CR88) 2011; 406
Zhang (CR85) 2015; 34
Du (CR101) 2012; 287
Ura (CR105) 2009; 49
Lu (CR44) 2016; 7
Li (CR58) 2015; 75
Memczak (CR62) 2013; 495
Gutschner (CR183) 2013; 73
Parkin (CR92) 2006; 118
Fang (CR31) 2017; 9
Maxwell, Fournier (CR188) 1995; 64
Jones-Rhoades, Bartel, Bartel (CR195) 2006; 57
Brockhausen (CR132) 2015; 35
Wang, Heegaard, Orum (CR28) 2012; 142
Ma, Bajic, Zhang (CR37) 2013; 10
Allis, Jenuwein (CR150) 2016; 17
Ji (CR147) 2015; 62
Salzman, Gawad, Wang, Lacayo, Brown (CR61) 2012; 7
Machlin, Sarnow, Sagan (CR110) 2011; 108
Huang, Wang, Guo, Sun (CR153) 2010; 52
Bernstein, Caudy, Hammond, Hannon (CR190) 2001; 409
Liu (CR192) 2004; 305
Xu (CR30) 2014; 13
Yuan (CR140) 2014; 25
Yang (CR49) 2011; 18
Janssen (CR177) 2013; 368
Li (CR123) 2015; 21
Atanasovska (CR125) 2017; 66
Caruso (CR12) 2017; 66
Murakami (CR13) 2006; 25
Fu (CR51) 2015; 63
Hu (CR100) 2016; 6
Quagliata (CR53) 2014; 59
Yang (CR39) 2017; 8
Zhang (CR134) 2014; 33
Murakami, Aly, Tajima, Inoue, Shimotohno (CR112) 2009; 50
Zhou, Zhang, Yu (CR161) 2017; 85
Yang (CR160) 2011; 54
Li (CR45) 2016; 7
Tao (CR135) 2013; 210
Kruger (CR187) 1982; 31
Park, Gaur, Lengyel, Peter (CR137) 2008; 22
Luna (CR111) 2015; 160
Zhang (CR115) 2015; 6
Wang (CR95) 2012; 55
Wong, Ng (CR4) 2008; 28
Wang (CR149) 2016; 64
Fornari (CR78) 2009; 69
Zhu, Yuan, Zhu, Li, Cheng (CR55) 2016; 283
Garofalo (CR89) 2009; 16
Li (CR54) 2016; 35
Wu (CR96) 2011; 105
Lin (CR130) 2013; 32
Kitagawa (CR11) 2013; 104
Jiang (CR14) 2008; 14
Hessein (CR93) 2005; 91
Brannan, Dees, Ingram, Tilghman (CR193) 1990; 10
Gupta (CR47) 2010; 464
CR180
Gailhouste (CR152) 2013; 58
Kozomara, Griffiths-Jones (CR9) 2014; 42
Meng (CR15) 2007; 133
Wong (CR129) 2015; 6
Wong (CR127) 2011; 140
Brennecke (CR197) 2007; 128
Mizuguchi, Takizawa, Yoshida, Uchida (CR27) 2016; 46
Le Thomas (CR198) 2013; 27
Tsang (CR38) 2015; 35
Zheng (CR179) 2015; 11
Sui (CR141) 2016; 94
Datta (CR157) 2008; 68
Poliseno (CR66) 2010; 465
Chen (CR124) 2016; 6
Hsu (CR72) 2012; 122
Su (CR20) 2009; 69
Krutzfeldt (CR71) 2005; 438
Au (CR158) 2012; 56
Yang (CR171) 2017; 8
J Huang (BFnrgastro2017169_CR153) 2010; 52
H Xie (BFnrgastro2017169_CR168) 2013; 2013
CC Wong (BFnrgastro2017169_CR127) 2011; 140
W Guo (BFnrgastro2017169_CR84) 2015; 62
CM Wong (BFnrgastro2017169_CR155) 2016; 63
Z Lu (BFnrgastro2017169_CR44) 2016; 7
JJ Quinn (BFnrgastro2017169_CR35) 2016; 17
F Fornari (BFnrgastro2017169_CR91) 2017; 23
ES Machlin (BFnrgastro2017169_CR110) 2011; 108
M Hessein (BFnrgastro2017169_CR93) 2005; 91
MS Beg (BFnrgastro2017169_CR181) 2015
S Caruso (BFnrgastro2017169_CR12) 2017; 66
LM Li (BFnrgastro2017169_CR163) 2010; 70
MD Huang (BFnrgastro2017169_CR159) 2015; 8
F Borel (BFnrgastro2017169_CR26) 2012; 56
SP Li (BFnrgastro2017169_CR45) 2016; 7
F Zheng (BFnrgastro2017169_CR126) 2012; 61
X Wang (BFnrgastro2017169_CR149) 2016; 64
B Wang (BFnrgastro2017169_CR76) 2014; 59
J Salzman (BFnrgastro2017169_CR59) 2016; 32
A Sehgal (BFnrgastro2017169_CR172) 2013; 59
J Kota (BFnrgastro2017169_CR178) 2009; 137
K Kruger (BFnrgastro2017169_CR187) 1982; 31
FH Tsang (BFnrgastro2017169_CR38) 2015; 35
MW Jones-Rhoades (BFnrgastro2017169_CR195) 2006; 57
J Ding (BFnrgastro2017169_CR128) 2010; 12
M Ward (BFnrgastro2017169_CR36) 2015; 1
J Brockhausen (BFnrgastro2017169_CR132) 2015; 35
H Xia (BFnrgastro2017169_CR133) 2013; 58
CL Chen (BFnrgastro2017169_CR68) 2015; 44
B Atanasovska (BFnrgastro2017169_CR125) 2017; 66
K Panzitt (BFnrgastro2017169_CR43) 2007; 132
F Fornari (BFnrgastro2017169_CR86) 2008; 27
M Cui (BFnrgastro2017169_CR46) 2015; 75
H Kutay (BFnrgastro2017169_CR74) 2006; 99
CH Li (BFnrgastro2017169_CR98) 2014; 50
IM Pedersen (BFnrgastro2017169_CR113) 2007; 449
L Quagliata (BFnrgastro2017169_CR53) 2014; 59
L Li (BFnrgastro2017169_CR148) 2015; 64
O Cheung (BFnrgastro2017169_CR118) 2008; 48
F Meng (BFnrgastro2017169_CR15) 2007; 133
XW Wang (BFnrgastro2017169_CR28) 2012; 142
S Tang (BFnrgastro2017169_CR182) 2016; 7
Y Du (BFnrgastro2017169_CR101) 2012; 287
A Jemal (BFnrgastro2017169_CR1) 2011; 61
F Zheng (BFnrgastro2017169_CR179) 2015; 11
L Poliseno (BFnrgastro2017169_CR66) 2010; 465
Y Yang (BFnrgastro2017169_CR39) 2017; 8
JF Huang (BFnrgastro2017169_CR102) 2013; 57
P Zhu (BFnrgastro2017169_CR42) 2016; 23
MD Huang (BFnrgastro2017169_CR162) 2015; 14
SL Au (BFnrgastro2017169_CR158) 2012; 56
H Peng (BFnrgastro2017169_CR67) 2015; 6
ES Maxwell (BFnrgastro2017169_CR188) 1995; 64
C Li (BFnrgastro2017169_CR73) 2016; 7
S Memczak (BFnrgastro2017169_CR62) 2013; 495
KV Morris (BFnrgastro2017169_CR151) 2014; 15
M Zhou (BFnrgastro2017169_CR161) 2017; 85
Y Xu (BFnrgastro2017169_CR121) 2015; 6
F Fornari (BFnrgastro2017169_CR83) 2010; 70
JK Park (BFnrgastro2017169_CR175) 2011; 71
WC Tsai (BFnrgastro2017169_CR120) 2012; 122
CJ Sui (BFnrgastro2017169_CR141) 2016; 94
L Wang (BFnrgastro2017169_CR69) 2013; 34
SL Zhou (BFnrgastro2017169_CR139) 2016; 63
KH Chuang (BFnrgastro2017169_CR154) 2015; 62
CM Wong (BFnrgastro2017169_CR23) 2012; 55
N Brockdorff (BFnrgastro2017169_CR194) 1991; 351
Y Li (BFnrgastro2017169_CR107) 2013; 110
T Li (BFnrgastro2017169_CR58) 2015; 75
LF Zhang (BFnrgastro2017169_CR85) 2015; 34
BFnrgastro2017169_CR180
KR Rosenbloom (BFnrgastro2017169_CR6) 2012; 40
N Kitagawa (BFnrgastro2017169_CR11) 2013; 104
J Zhou (BFnrgastro2017169_CR164) 2011; 29
QW Wong (BFnrgastro2017169_CR17) 2010; 16
L Zhang (BFnrgastro2017169_CR142) 2013; 34
P Zhu (BFnrgastro2017169_CR41) 2016; 7
P Li (BFnrgastro2017169_CR123) 2015; 21
Y Enuka (BFnrgastro2017169_CR64) 2016; 44
G Chen (BFnrgastro2017169_CR124) 2016; 6
J Jiang (BFnrgastro2017169_CR14) 2008; 14
J Xu (BFnrgastro2017169_CR80) 2012; 32
Y Zhang (BFnrgastro2017169_CR114) 2012; 56
RE Lanford (BFnrgastro2017169_CR176) 2010; 327
T Gutschner (BFnrgastro2017169_CR183) 2013; 73
Z Yang (BFnrgastro2017169_CR49) 2011; 18
G Hutvagner (BFnrgastro2017169_CR173) 2004; 2
JR Warner (BFnrgastro2017169_CR185) 1966; 19
H Su (BFnrgastro2017169_CR20) 2009; 69
PT Law (BFnrgastro2017169_CR34) 2013; 58
ZM Younossi (BFnrgastro2017169_CR2) 2015; 62
S Ura (BFnrgastro2017169_CR105) 2009; 49
C Coulouarn (BFnrgastro2017169_CR75) 2009; 28
J Salzman (BFnrgastro2017169_CR61) 2012; 7
DN Fan (BFnrgastro2017169_CR156) 2013; 57
TM Williams (BFnrgastro2017169_CR196) 2008; 134
SH Hsu (BFnrgastro2017169_CR72) 2012; 122
T Reya (BFnrgastro2017169_CR143) 2001; 414
G Xu (BFnrgastro2017169_CR30) 2014; 13
MC Siomi (BFnrgastro2017169_CR32) 2011; 12
SM Berget (BFnrgastro2017169_CR186) 1977; 74
MM Kamel (BFnrgastro2017169_CR169) 2016; 168
P Gao (BFnrgastro2017169_CR22) 2011; 54
L Liang (BFnrgastro2017169_CR19) 2010; 52
A Wree (BFnrgastro2017169_CR116) 2013; 10
CM Wong (BFnrgastro2017169_CR129) 2015; 6
KC Wang (BFnrgastro2017169_CR52) 2011; 472
E Bernstein (BFnrgastro2017169_CR190) 2001; 409
J Liu (BFnrgastro2017169_CR192) 2004; 305
Y Mizuguchi (BFnrgastro2017169_CR27) 2016; 46
GT Williams (BFnrgastro2017169_CR29) 2012; 12
M Garofalo (BFnrgastro2017169_CR89) 2009; 16
L Gailhouste (BFnrgastro2017169_CR152) 2013; 58
CI Brannan (BFnrgastro2017169_CR193) 1990; 10
GA Michelotti (BFnrgastro2017169_CR117) 2013; 10
M Ha (BFnrgastro2017169_CR10) 2014; 15
R Dhanasekaran (BFnrgastro2017169_CR3) 2012; 4
S Giordano (BFnrgastro2017169_CR25) 2013; 57
CC Lau (BFnrgastro2017169_CR103) 2014; 25
T Yamashita (BFnrgastro2017169_CR145) 2009; 136
Y Murakami (BFnrgastro2017169_CR112) 2009; 50
J Hou (BFnrgastro2017169_CR82) 2011; 19
T Li (BFnrgastro2017169_CR54) 2016; 35
S Ma (BFnrgastro2017169_CR144) 2007; 132
J Li (BFnrgastro2017169_CR88) 2011; 406
WR Jeck (BFnrgastro2017169_CR60) 2013; 19
Y Dou (BFnrgastro2017169_CR65) 2016; 6
F Yang (BFnrgastro2017169_CR160) 2011; 54
CL Jopling (BFnrgastro2017169_CR108) 2005; 309
XT Zhu (BFnrgastro2017169_CR55) 2016; 283
S Jonas (BFnrgastro2017169_CR8) 2015; 16
S Ma (BFnrgastro2017169_CR146) 2010; 7
L Gramantieri (BFnrgastro2017169_CR87) 2009; 15
JJ Hu (BFnrgastro2017169_CR100) 2016; 6
Y Murakami (BFnrgastro2017169_CR13) 2006; 25
A Kozomara (BFnrgastro2017169_CR9) 2014; 42
J Brennecke (BFnrgastro2017169_CR197) 2007; 128
CJ Pirola (BFnrgastro2017169_CR119) 2015; 64
Y Wang (BFnrgastro2017169_CR21) 2010; 53
JL Rinn (BFnrgastro2017169_CR50) 2007; 129
DM Parkin (BFnrgastro2017169_CR92) 2006; 118
J Krutzfeldt (BFnrgastro2017169_CR71) 2005; 438
L Yu (BFnrgastro2017169_CR63) 2016; 11
C Jopling (BFnrgastro2017169_CR70) 2012; 9
Y Wang (BFnrgastro2017169_CR40) 2015; 16
R Kogo (BFnrgastro2017169_CR48) 2011; 71
T Shimakami (BFnrgastro2017169_CR106) 2012; 109
ZH Tao (BFnrgastro2017169_CR135) 2013; 210
BFnrgastro2017169_CR165
JH Yuan (BFnrgastro2017169_CR140) 2014; 25
BFnrgastro2017169_CR166
H Zhang (BFnrgastro2017169_CR115) 2015; 6
JM Luna (BFnrgastro2017169_CR111) 2015; 160
BFnrgastro2017169_CR167
F Rizzo (BFnrgastro2017169_CR33) 2016; 7
N Yang (BFnrgastro2017169_CR171) 2017; 8
E Callegari (BFnrgastro2017169_CR90) 2012; 56
BD Adams (BFnrgastro2017169_CR184) 2017; 127
RA Gupta (BFnrgastro2017169_CR47) 2010; 464
X Fang (BFnrgastro2017169_CR31) 2017; 9
J Ji (BFnrgastro2017169_CR147) 2015; 62
SM Park (BFnrgastro2017169_CR137) 2008; 22
L Gramantieri (BFnrgastro2017169_CR18) 2007; 67
HW Liang (BFnrgastro2017169_CR104) 2016; 64
JP Zhang (BFnrgastro2017169_CR134) 2014; 33
CD Allis (BFnrgastro2017169_CR150) 2016; 17
SX Yuan (BFnrgastro2017169_CR56) 2014; 349
RC Lee (BFnrgastro2017169_CR189) 1993; 75
FH Crick (BFnrgastro2017169_CR5) 1958; 12
JH Fang (BFnrgastro2017169_CR131) 2011; 54
J Tang (BFnrgastro2017169_CR170) 2015; 6
CM Wong (BFnrgastro2017169_CR24) 2013; 5
Z Liu (BFnrgastro2017169_CR57) 2016; 473
HL Janssen (BFnrgastro2017169_CR177) 2013; 368
G Wu (BFnrgastro2017169_CR96) 2011; 105
X Xu (BFnrgastro2017169_CR97) 2013; 123
YT Chiu (BFnrgastro2017169_CR94) 2016; 64
L Ma (BFnrgastro2017169_CR37) 2013; 10
J Datta (BFnrgastro2017169_CR157) 2008; 68
P Yang (BFnrgastro2017169_CR138) 2012; 22
A Garcia-Sastre (BFnrgastro2017169_CR109) 2013; 110
Y Lee (BFnrgastro2017169_CR191) 2003; 425
JL Huang (BFnrgastro2017169_CR99) 2015; 6
F Fornari (BFnrgastro2017169_CR78) 2009; 69
U Burk (BFnrgastro2017169_CR136) 2008; 9
WM Fu (BFnrgastro2017169_CR51) 2015; 63
A Simerzin (BFnrgastro2017169_CR81) 2016; 64
T Derrien (BFnrgastro2017169_CR7) 2012; 22
C Wang (BFnrgastro2017169_CR95) 2012; 55
YH Lin (BFnrgastro2017169_CR130) 2013; 32
BFnrgastro2017169_CR122
CM Wong (BFnrgastro2017169_CR4) 2008; 28
P Pineau (BFnrgastro2017169_CR16) 2010; 107
SC Wang (BFnrgastro2017169_CR79) 2014; 9
CC Wong (BFnrgastro2017169_CR77) 2014; 9
J Elmen (BFnrgastro2017169_CR174) 2008; 452
A Le Thomas (BFnrgastro2017169_CR198) 2013; 27
References_xml – volume: 9
  start-page: 137
  year: 2012
  end-page: 142
  ident: CR70
  article-title: Liver-specific microRNA-122: biogenesis and function
  publication-title: RNA Biol.
– volume: 132
  start-page: 330
  year: 2007
  end-page: 342
  ident: CR43
  article-title: Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA
  publication-title: Gastroenterology
– volume: 168
  start-page: 134
  year: 2016
  end-page: 145
  ident: CR169
  article-title: Investigation of long noncoding RNAs expression profile as potential serum biomarkers in patients with hepatocellular carcinoma
  publication-title: Transl Res.
– volume: 327
  start-page: 198
  year: 2010
  end-page: 201
  ident: CR176
  article-title: Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection
  publication-title: Science
– volume: 67
  start-page: 6092
  year: 2007
  end-page: 6099
  ident: CR18
  article-title: Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma
  publication-title: Cancer Res.
– volume: 110
  start-page: 1881
  year: 2013
  end-page: 1886
  ident: CR107
  article-title: Competing and noncompeting activities of miR-122 and the 5′ exonuclease Xrn1 in regulation of hepatitis C virus replication
  publication-title: Proc. Natl Acad. Sci. USA
– volume: 110
  start-page: 1571
  year: 2013
  end-page: 1572
  ident: CR109
  article-title: miR-122 is more than a shield for the hepatitis C virus genome
  publication-title: Proc. Natl Acad. Sci. USA
– volume: 12
  start-page: 390
  year: 2010
  end-page: 399
  ident: CR128
  article-title: Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA
  publication-title: Nat. Cell Biol.
– ident: CR167
– volume: 10
  start-page: 925
  year: 2013
  end-page: 933
  ident: CR37
  article-title: On the classification of long non-coding RNAs
  publication-title: RNA Biol.
– volume: 71
  start-page: 6320
  year: 2011
  end-page: 6326
  ident: CR48
  article-title: Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers
  publication-title: Cancer Res.
– volume: 122
  start-page: 2871
  year: 2012
  end-page: 2883
  ident: CR72
  article-title: Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver
  publication-title: J. Clin. Invest.
– volume: 10
  start-page: 627
  year: 2013
  end-page: 636
  ident: CR116
  article-title: From NAFLD to NASH to cirrhosis-new insights into disease mechanisms
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
– volume: 9
  start-page: e115036
  year: 2014
  ident: CR77
  article-title: Switching of pyruvate kinase isoform L to M2 promotes metabolic reprogramming in hepatocarcinogenesis
  publication-title: PLoS ONE
– volume: 7
  start-page: 42431
  year: 2016
  end-page: 42446
  ident: CR45
  article-title: LncRNA HULC enhances epithelial-mesenchymal transition to promote tumorigenesis and metastasis of hepatocellular carcinoma via the miR-200a-3p/ZEB1 signaling pathway
  publication-title: Oncotarget
– volume: 94
  start-page: 1281
  year: 2016
  end-page: 1296
  ident: CR141
  article-title: Long noncoding RNA GIHCG promotes hepatocellular carcinoma progression through epigenetically regulating miR-200b/a/429
  publication-title: J. Mol. Med.
– volume: 53
  start-page: 57
  year: 2010
  end-page: 66
  ident: CR21
  article-title: Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3
  publication-title: J. Hepatol.
– volume: 18
  start-page: 1243
  year: 2011
  end-page: 1250
  ident: CR49
  article-title: Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation
  publication-title: Ann. Surg. Oncol.
– volume: 16
  start-page: 421
  year: 2015
  end-page: 433
  ident: CR8
  article-title: Towards a molecular understanding of microRNA-mediated gene silencing
  publication-title: Nat. Rev. Genet.
– volume: 12
  start-page: 246
  year: 2011
  end-page: 258
  ident: CR32
  article-title: PIWI-interacting small RNAs: the vanguard of genome defence
  publication-title: Nat. Rev. Mol. Cell Biol.
– volume: 14
  start-page: 419
  year: 2008
  end-page: 427
  ident: CR14
  article-title: Association of microRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival
  publication-title: Clin. Cancer Res.
– volume: 19
  start-page: 232
  year: 2011
  end-page: 243
  ident: CR82
  article-title: Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma
  publication-title: Cancer Cell
– volume: 9
  start-page: 582
  year: 2008
  end-page: 589
  ident: CR136
  article-title: A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
  publication-title: EMBO Rep.
– volume: 5
  start-page: 49
  year: 2013
  end-page: 60
  ident: CR24
  article-title: Regulation of hepatocarcinogenesis by microRNAs
  publication-title: Front. Biosci.
– volume: 127
  start-page: 761
  year: 2017
  end-page: 771
  ident: CR184
  article-title: Targeting noncoding RNAs in disease
  publication-title: J. Clin. Invest.
– volume: 27
  start-page: 390
  year: 2013
  end-page: 399
  ident: CR198
  article-title: Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state
  publication-title: Genes Dev.
– volume: 134
  start-page: 610
  year: 2008
  end-page: 623
  ident: CR196
  article-title: The regulation and evolution of a genetic switch controlling sexually dimorphic traits in
  publication-title: Cell
– volume: 54
  start-page: 1729
  year: 2011
  end-page: 1740
  ident: CR131
  article-title: MicroRNA-29b suppresses tumor angiogenesis, invasion, and metastasis by regulating matrix metalloproteinase 2 expression
  publication-title: Hepatology
– volume: 35
  start-page: 1597
  year: 2015
  end-page: 1606
  ident: CR38
  article-title: Long non-coding RNA HOTTIP is frequently up-regulated in hepatocellular carcinoma and is targeted by tumour suppressive miR-125b
  publication-title: Liver Int.
– volume: 7
  start-page: 73257
  year: 2016
  end-page: 73269
  ident: CR182
  article-title: An artificial lncRNA targeting multiple miRNAs overcomes sorafenib resistance in hepatocellular carcinoma cells
  publication-title: Oncotarget
– volume: 105
  start-page: 146
  year: 2011
  end-page: 153
  ident: CR96
  article-title: Hepatitis B virus X protein downregulates expression of the miR-16 family in malignant hepatocytes
  publication-title: Br. J. Cancer
– volume: 64
  start-page: 1623
  year: 2016
  end-page: 1636
  ident: CR81
  article-title: The liver-specific microRNA-122*, the complementary strand of microRNA-122, acts as a tumor suppressor by modulating the p53/mouse double minute 2 homolog circuitry
  publication-title: Hepatology
– volume: 46
  start-page: 391
  year: 2016
  end-page: 406
  ident: CR27
  article-title: Dysregulated miRNA in progression of hepatocellular carcinoma: A systematic review
  publication-title: Hepatol. Res.
– volume: 56
  start-page: 622
  year: 2012
  end-page: 631
  ident: CR158
  article-title: Enhancer of zeste homolog 2 epigenetically silences multiple tumor suppressor microRNAs to promote liver cancer metastasis
  publication-title: Hepatology
– volume: 55
  start-page: 108
  year: 2012
  end-page: 120
  ident: CR95
  article-title: Hepatitis B virus X (HBx) induces tumorigenicity of hepatic progenitor cells in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated HBx transgenic mice
  publication-title: Hepatology
– volume: 10
  start-page: 656
  year: 2013
  end-page: 665
  ident: CR117
  article-title: NAFLD, NASH and liver cancer
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
– volume: 56
  start-page: 1371
  year: 2012
  end-page: 1383
  ident: CR26
  article-title: Diagnostic and therapeutic potential of miRNA signatures in patients with hepatocellular carcinoma
  publication-title: J. Hepatol.
– volume: 23
  start-page: 3953
  year: 2017
  end-page: 3965
  ident: CR91
  article-title: In hepatocellular carcinoma miR-221 modulates sorafenib resistance through inhibition of caspase-3-mediated apoptosis
  publication-title: Clin. Cancer Res.
– volume: 75
  start-page: 843
  year: 1993
  end-page: 854
  ident: CR189
  article-title: The heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
  publication-title: Cell
– volume: 44
  start-page: 1370
  year: 2016
  end-page: 1383
  ident: CR64
  article-title: Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor
  publication-title: Nucleic Acids Res.
– volume: 64
  start-page: 800
  year: 2015
  end-page: 812
  ident: CR119
  article-title: Circulating microRNA signature in non-alcoholic fatty liver disease: from serum non-coding RNAs to liver histology and disease pathogenesis
  publication-title: Gut
– volume: 14
  start-page: 165
  year: 2015
  ident: CR162
  article-title: Long non-coding RNA TUG1 is up-regulated in hepatocellular carcinoma and promotes cell growth and apoptosis by epigenetically silencing of KLF2
  publication-title: Mol. Cancer
– volume: 7
  start-page: 241
  year: 2016
  end-page: 254
  ident: CR44
  article-title: Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1)
  publication-title: Oncotarget
– volume: 15
  start-page: 423
  year: 2014
  end-page: 437
  ident: CR151
  article-title: The rise of regulatory RNA
  publication-title: Nat. Rev. Genet.
– volume: 74
  start-page: 3171
  year: 1977
  end-page: 3175
  ident: CR186
  article-title: Spliced segments at the 5′ terminus of adenovirus 2 late mRNA
  publication-title: Proc. Natl Acad. Sci. USA
– volume: 71
  start-page: 7608
  year: 2011
  end-page: 7616
  ident: CR175
  article-title: miR-221 silencing blocks hepatocellular carcinoma and promotes survival
  publication-title: Cancer Res.
– volume: 34
  start-page: 577
  year: 2013
  end-page: 586
  ident: CR142
  article-title: Epigenetic activation of the MiR-200 family contributes to H19-mediated metastasis suppression in hepatocellular carcinoma
  publication-title: Carcinogenesis
– volume: 25
  start-page: 666
  year: 2014
  end-page: 681
  ident: CR140
  article-title: A long noncoding RNA activated by TGF-β promotes the invasion-metastasis cascade in hepatocellular carcinoma
  publication-title: Cancer Cell
– volume: 19
  start-page: 141
  year: 2013
  end-page: 157
  ident: CR60
  article-title: Circular RNAs are abundant, conserved, and associated with ALU repeats
  publication-title: RNA
– volume: 56
  start-page: 1631
  year: 2012
  end-page: 1640
  ident: CR114
  article-title: Hepatitis C virus-induced up-regulation of microRNA-155 promotes hepatocarcinogenesis by activating Wnt signaling
  publication-title: Hepatology
– volume: 6
  start-page: 43770
  year: 2015
  end-page: 43778
  ident: CR115
  article-title: Long non-coding RNA expression profiles of hepatitis C virus-related dysplasia and hepatocellular carcinoma
  publication-title: Oncotarget
– volume: 59
  start-page: 1354
  year: 2013
  end-page: 1359
  ident: CR172
  article-title: Liver as a target for oligonucleotide therapeutics
  publication-title: J. Hepatol.
– volume: 73
  start-page: 1180
  year: 2013
  end-page: 1189
  ident: CR183
  article-title: The noncoding RNA MALAT1 is a critical regulator of the metastasis phenotype of lung cancer cells
  publication-title: Cancer Res.
– volume: 160
  start-page: 1099
  year: 2015
  end-page: 1110
  ident: CR111
  article-title: Hepatitis C virus RNA functionally sequesters miR-122
  publication-title: Cell
– volume: 351
  start-page: 329
  year: 1991
  end-page: 331
  ident: CR194
  article-title: Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome
  publication-title: Nature
– volume: 22
  start-page: 1775
  year: 2012
  end-page: 1789
  ident: CR7
  article-title: The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression
  publication-title: Genome Res.
– volume: 473
  start-page: 1268
  year: 2016
  end-page: 1275
  ident: CR57
  article-title: Long non-coding RNA HNF1A-AS1 functioned as an oncogene and autophagy promoter in hepatocellular carcinoma through sponging hsa-miR-30b-5p
  publication-title: Biochem. Biophys. Res. Commun.
– volume: 21
  start-page: 455
  year: 2015
  end-page: 467
  ident: CR123
  article-title: A liver-enriched long non-coding RNA, lncLSTR, regulates systemic lipid metabolism in mice
  publication-title: Cell Metab.
– volume: 11
  start-page: e1004873
  year: 2015
  ident: CR179
  article-title: Systemic delivery of microRNA-101 potently inhibits hepatocellular carcinoma by repressing multiple targets
  publication-title: PLoS Genet.
– volume: 64
  start-page: 1283
  year: 2016
  end-page: 1294
  ident: CR149
  article-title: Long non-coding RNA DILC regulates liver cancer stem cells via IL-6/STAT3 axis
  publication-title: J. Hepatol.
– volume: 63
  start-page: 474
  year: 2016
  end-page: 487
  ident: CR155
  article-title: Up-regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis
  publication-title: Hepatology
– volume: 449
  start-page: 919
  year: 2007
  end-page: 922
  ident: CR113
  article-title: Interferon modulation of cellular microRNAs as an antiviral mechanism
  publication-title: Nature
– volume: 6
  start-page: 4505
  year: 2015
  end-page: 4515
  ident: CR170
  article-title: Circulation long non-coding RNAs act as biomarkers for predicting tumorigenesis and metastasis in hepatocellular carcinoma
  publication-title: Oncotarget
– volume: 52
  start-page: 1731
  year: 2010
  end-page: 1740
  ident: CR19
  article-title: MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2
  publication-title: Hepatology
– volume: 50
  start-page: 453
  year: 2009
  end-page: 460
  ident: CR112
  article-title: Regulation of the hepatitis C virus genome replication by miR-199a
  publication-title: J. Hepatol.
– volume: 8
  start-page: 14421
  year: 2017
  ident: CR39
  article-title: Recurrently deregulated lncRNAs in hepatocellular carcinoma
  publication-title: Nat. Commun.
– ident: CR122
– volume: 129
  start-page: 1311
  year: 2007
  end-page: 1323
  ident: CR50
  article-title: Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs
  publication-title: Cell
– volume: 63
  start-page: 886
  year: 2015
  end-page: 895
  ident: CR51
  article-title: Hotair mediates hepatocarcinogenesis through suppressing miRNA-218 expression and activating P14 and P16 signaling
  publication-title: J. Hepatol.
– volume: 27
  start-page: 5651
  year: 2008
  end-page: 5661
  ident: CR86
  article-title: MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma
  publication-title: Oncogene
– volume: 464
  start-page: 1071
  year: 2010
  end-page: 1076
  ident: CR47
  article-title: Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
  publication-title: Nature
– volume: 69
  start-page: 5761
  year: 2009
  end-page: 5767
  ident: CR78
  article-title: MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells
  publication-title: Cancer Res.
– volume: 66
  start-page: 734
  year: 2017
  end-page: 742
  ident: CR12
  article-title: Germline and somatic DICER1 mutations in familial and sporadic liver tumors
  publication-title: J. Hepatol.
– volume: 472
  start-page: 120
  year: 2011
  end-page: 124
  ident: CR52
  article-title: A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression
  publication-title: Nature
– volume: 25
  start-page: 335
  year: 2014
  end-page: 349
  ident: CR103
  article-title: Viral-human chimeric transcript predisposes risk to liver cancer development and progression
  publication-title: Cancer Cell
– volume: 15
  start-page: 509
  year: 2014
  end-page: 524
  ident: CR10
  article-title: Regulation of microRNA biogenesis
  publication-title: Nat. Rev. Mol. Cell Biol.
– volume: 32
  start-page: 752
  year: 2012
  end-page: 760
  ident: CR80
  article-title: MicroRNA-122 suppresses cell proliferation and induces cell apoptosis in hepatocellular carcinoma by directly targeting Wnt/ β-catenin pathway
  publication-title: Liver Int.
– volume: 99
  start-page: 671
  year: 2006
  end-page: 678
  ident: CR74
  article-title: Downregulation of miR-122 in the rodent and human hepatocellular carcinomas
  publication-title: J. Cell. Biochem.
– volume: 6
  start-page: 7466
  year: 2015
  ident: CR121
  article-title: A metabolic stress-inducible miR-34a-HNF4α pathway regulates lipid and lipoprotein metabolism
  publication-title: Nat. Commun.
– volume: 2
  start-page: E98
  year: 2004
  ident: CR173
  article-title: Sequence-specific inhibition of small RNA function
  publication-title: PLoS Biol.
– volume: 210
  start-page: 789
  year: 2013
  end-page: 803
  ident: CR135
  article-title: miR-612 suppresses the invasive-metastatic cascade in hepatocellular carcinoma
  publication-title: J. Exp. Med.
– volume: 8
  start-page: 3683
  year: 2017
  end-page: 3695
  ident: CR171
  article-title: The role of extracellular vesicles in mediating progression, metastasis and potential treatment of hepatocellular carcinoma
  publication-title: Oncotarget
– volume: 64
  start-page: 156
  year: 2015
  end-page: 167
  ident: CR148
  article-title: Epigenetic modification of MiR-429 promotes liver tumour-initiating cell properties by targeting Rb binding protein 4
  publication-title: Gut
– volume: 118
  start-page: 3030
  year: 2006
  end-page: 3044
  ident: CR92
  article-title: The global health burden of infection-associated cancers in the year 2002
  publication-title: Int. J. Cancer
– volume: 58
  start-page: 629
  year: 2013
  end-page: 641
  ident: CR133
  article-title: MicroRNA-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer
  publication-title: Hepatology
– volume: 7
  start-page: 694
  year: 2010
  end-page: 707
  ident: CR146
  article-title: miR-130b Promotes CD133 liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1
  publication-title: Cell Stem Cell
– volume: 63
  start-page: 1560
  year: 2016
  end-page: 1575
  ident: CR139
  article-title: miR-28-5p-IL-34-macrophage feedback loop modulates hepatocellular carcinoma metastasis
  publication-title: Hepatology
– volume: 414
  start-page: 105
  year: 2001
  end-page: 111
  ident: CR143
  article-title: Stem cells, cancer, and cancer stem cells
  publication-title: Nature
– volume: 409
  start-page: 363
  year: 2001
  end-page: 366
  ident: CR190
  article-title: Role for a bidentate ribonuclease in the initiation step of RNA interference
  publication-title: Nature
– volume: 140
  start-page: 322
  year: 2011
  end-page: 331
  ident: CR127
  article-title: The microRNA miR-139 suppresses metastasis and progression of hepatocellular carcinoma by down-regulating Rho-kinase 2
  publication-title: Gastroenterology
– volume: 50
  start-page: 2560
  year: 2014
  end-page: 2569
  ident: CR98
  article-title: Hepatitis B virus X protein promotes hepatocellular carcinoma transformation through interleukin-6 activation of microRNA-21 expression
  publication-title: Eur. J. Cancer
– volume: 8
  start-page: 50
  year: 2015
  ident: CR159
  article-title: Long non-coding RNA ANRIL is upregulated in hepatocellular carcinoma and regulates cell apoptosis by epigenetic silencing of KLF2
  publication-title: J. Hematol. Oncol.
– volume: 406
  start-page: 70
  year: 2011
  end-page: 73
  ident: CR88
  article-title: Expression of serum miR-221 in human hepatocellular carcinoma and its prognostic significance
  publication-title: Biochem. Biophys. Res. Commun.
– volume: 123
  start-page: 630
  year: 2013
  end-page: 645
  ident: CR97
  article-title: Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis
  publication-title: J. Clin. Invest.
– ident: CR166
– volume: 28
  start-page: 3526
  year: 2009
  end-page: 3536
  ident: CR75
  article-title: Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties
  publication-title: Oncogene
– volume: 35
  start-page: 240
  year: 2015
  end-page: 253
  ident: CR132
  article-title: miR-181a mediates TGF-beta-induced hepatocyte EMT and is dysregulated in cirrhosis and hepatocellular cancer
  publication-title: Liver Int.
– volume: 29
  start-page: 4781
  year: 2011
  end-page: 4788
  ident: CR164
  article-title: Plasma microRNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma
  publication-title: J. Clin. Oncol.
– volume: 70
  start-page: 9798
  year: 2010
  end-page: 9807
  ident: CR163
  article-title: Serum microRNA profiles serve as novel biomarkers for HBV infection and diagnosis of HBV-positive hepatocarcinoma
  publication-title: Cancer Res.
– volume: 55
  start-page: 1453
  year: 2012
  end-page: 1461
  ident: CR23
  article-title: Sequential alterations of microRNA expression in hepatocellular carcinoma development and venous metastasis
  publication-title: Hepatology
– volume: 32
  start-page: 309
  year: 2016
  end-page: 316
  ident: CR59
  article-title: Circular RNA expression: its potential regulation and function
  publication-title: Trends Genet.
– volume: 142
  start-page: 1431
  year: 2012
  end-page: 1443
  ident: CR28
  article-title: MicroRNAs in liver disease
  publication-title: Gastroenterology
– volume: 28
  start-page: 160
  year: 2008
  end-page: 174
  ident: CR4
  article-title: Molecular pathogenesis of hepatocellular carcinoma
  publication-title: Liver Int.
– volume: 11
  start-page: e0158347
  year: 2016
  ident: CR63
  article-title: The Circular RNA Cdr1as Act as an oncogene in hepatocellular carcinoma through targeting miR-7 expression
  publication-title: PLoS ONE
– volume: 57
  start-page: 1882
  year: 2013
  end-page: 1892
  ident: CR102
  article-title: Hepatitis B virus X protein (HBx)-related long noncoding RNA (lncRNA) down-regulated expression by HBx (Dreh) inhibits hepatocellular carcinoma metastasis by targeting the intermediate filament protein vimentin
  publication-title: Hepatology
– volume: 107
  start-page: 264
  year: 2010
  end-page: 269
  ident: CR16
  article-title: miR-221 overexpression contributes to liver tumorigenesis
  publication-title: Proc. Natl Acad. Sci. USA
– volume: 44
  start-page: 71
  year: 2015
  end-page: 81
  ident: CR68
  article-title: Suppression of hepatocellular carcinoma by baculovirus-mediated expression of long non-coding RNA PTENP1 and microRNA regulation
  publication-title: Biomaterials
– volume: 34
  start-page: 2671
  year: 2015
  end-page: 2685
  ident: CR85
  article-title: Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepatocellular carcinoma
  publication-title: EMBO J.
– volume: 495
  start-page: 333
  year: 2013
  end-page: 338
  ident: CR62
  article-title: Circular RNAs are a large class of animal RNAs with regulatory potency
  publication-title: Nature
– volume: 57
  start-page: 637
  year: 2013
  end-page: 647
  ident: CR156
  article-title: Histone lysine methyltransferase, suppressor of variegation 3–9 homolog 1, promotes hepatocellular carcinoma progression and is negatively regulated by microRNA-125b
  publication-title: Hepatology
– volume: 31
  start-page: 147
  year: 1982
  end-page: 157
  ident: CR187
  article-title: Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena
  publication-title: Cell
– volume: 104
  start-page: 543
  year: 2013
  end-page: 551
  ident: CR11
  article-title: Downregulation of the microRNA biogenesis components and its association with poor prognosis in hepatocellular carcinoma
  publication-title: Cancer Sci.
– volume: 64
  start-page: 1256
  year: 2016
  end-page: 1264
  ident: CR94
  article-title: Novel pre-mRNA splicing of intronically integrated HBV generates oncogenic chimera in hepatocellular carcinoma
  publication-title: J. Hepatol.
– volume: 66
  start-page: 794
  year: 2017
  end-page: 808
  ident: CR125
  article-title: A liver-specific long non-coding RNA with a role in cell viability is elevated in human non-alcoholic steatohepatitis
  publication-title: Hepatology
– volume: 438
  start-page: 685
  year: 2005
  end-page: 689
  ident: CR71
  article-title: Silencing of microRNAs with 'antagomirs'
  publication-title: Nature
– year: 2015
  ident: CR181
  publication-title: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics
– volume: 128
  start-page: 1089
  year: 2007
  end-page: 1103
  ident: CR197
  article-title: Discrete small RNA-generating loci as master regulators of transposon activity in
  publication-title: Cell
– volume: 122
  start-page: 2884
  year: 2012
  end-page: 2897
  ident: CR120
  article-title: MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis
  publication-title: J. Clin. Invest.
– volume: 34
  start-page: 1773
  year: 2013
  end-page: 1781
  ident: CR69
  article-title: Pseudogene OCT4-pg4 functions as a natural micro RNA sponge to regulate OCT4 expression by competing for miR-145 in hepatocellular carcinoma
  publication-title: Carcinogenesis
– volume: 16
  start-page: 498
  year: 2009
  end-page: 509
  ident: CR89
  article-title: miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation
  publication-title: Cancer Cell
– volume: 25
  start-page: 2537
  year: 2006
  end-page: 2545
  ident: CR13
  article-title: Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues
  publication-title: Oncogene
– volume: 22
  start-page: 894
  year: 2008
  end-page: 907
  ident: CR137
  article-title: The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
  publication-title: Genes Dev.
– volume: 7
  start-page: 13608
  year: 2016
  ident: CR41
  article-title: LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells
  publication-title: Nat. Commun.
– volume: 309
  start-page: 1577
  year: 2005
  end-page: 1581
  ident: CR108
  article-title: Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA
  publication-title: Science
– volume: 59
  start-page: 911
  year: 2014
  end-page: 923
  ident: CR53
  article-title: Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients
  publication-title: Hepatology
– volume: 349
  start-page: 87
  year: 2014
  end-page: 94
  ident: CR56
  article-title: Antisense long non-coding RNA PCNA-AS1 promotes tumor growth by regulating proliferating cell nuclear antigen in hepatocellular carcinoma
  publication-title: Cancer Lett.
– volume: 68
  start-page: 5049
  year: 2008
  end-page: 5058
  ident: CR157
  article-title: Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis
  publication-title: Cancer Res.
– volume: 61
  start-page: 278
  year: 2012
  end-page: 289
  ident: CR126
  article-title: The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2
  publication-title: Gut
– volume: 136
  start-page: 1012
  year: 2009
  end-page: 1024
  ident: CR145
  article-title: EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features
  publication-title: Gastroenterology
– volume: 59
  start-page: 555
  year: 2014
  end-page: 566
  ident: CR76
  article-title: Reciprocal regulation of microRNA-122 and c-Myc in hepatocellular cancer: role of E2F1 and transcription factor dimerization partner 2
  publication-title: Hepatology
– volume: 52
  start-page: 60
  year: 2010
  end-page: 70
  ident: CR153
  article-title: Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1
  publication-title: Hepatology
– volume: 61
  start-page: 69
  year: 2011
  end-page: 90
  ident: CR1
  article-title: Global cancer statistics
  publication-title: CA Cancer J. Clin.
– volume: 35
  start-page: 1575
  year: 2016
  end-page: 1584
  ident: CR54
  article-title: Upregulation of long noncoding RNA ZEB1-AS1 promotes tumor metastasis and predicts poor prognosis in hepatocellular carcinoma
  publication-title: Oncogene
– volume: 6
  start-page: 13658
  year: 2015
  end-page: 13670
  ident: CR129
  article-title: MiR-200b/200c/429 subfamily negatively regulates Rho/ROCK signaling pathway to suppress hepatocellular carcinoma metastasis
  publication-title: Oncotarget
– volume: 2013
  start-page: 136106
  year: 2013
  ident: CR168
  article-title: Plasma HULC as a promising novel biomarker for the detection of hepatocellular carcinoma
  publication-title: Biomed. Res. Int.
– volume: 6
  start-page: 23521
  year: 2016
  ident: CR100
  article-title: HBx-upregulated lncRNA UCA1 promotes cell growth and tumorigenesis by recruiting EZH2 and repressing p27Kip1/CDK2 signaling
  publication-title: Sci. Rep.
– ident: CR165
– volume: 13
  start-page: 216
  year: 2014
  ident: CR30
  article-title: Small nucleolar RNA 113–111 suppresses tumorigenesis in hepatocellular carcinoma
  publication-title: Mol. Cancer
– volume: 62
  start-page: 829
  year: 2015
  end-page: 840
  ident: CR147
  article-title: Identification of microRNAs specific for epithelial cell adhesion molecule-positive tumor cells in hepatocellular carcinoma
  publication-title: Hepatology
– volume: 6
  start-page: 5666
  year: 2015
  end-page: 5677
  ident: CR67
  article-title: Pseudogene INTS6P1 regulates its cognate gene INTS6 through competitive binding of miR-17-5p in hepatocellular carcinoma
  publication-title: Oncotarget
– volume: 137
  start-page: 1005
  year: 2009
  end-page: 1017
  ident: CR178
  article-title: Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model
  publication-title: Cell
– volume: 16
  start-page: 867
  year: 2010
  end-page: 875
  ident: CR17
  article-title: MiR-222 overexpression confers cell migratory advantages in hepatocellular carcinoma through enhancing AKT signaling
  publication-title: Clin. Cancer Res.
– volume: 6
  start-page: 35531
  year: 2016
  ident: CR124
  article-title: LncRNA SRA promotes hepatic steatosis through repressing the expression of adipose triglyceride lipase (ATGL)
  publication-title: Sci. Rep.
– volume: 49
  start-page: 1098
  year: 2009
  end-page: 1112
  ident: CR105
  article-title: Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma
  publication-title: Hepatology
– volume: 75
  start-page: 3181
  year: 2015
  end-page: 3191
  ident: CR58
  article-title: Amplification of long noncoding RNA ZFAS1 promotes metastasis in hepatocellular carcinoma
  publication-title: Cancer Res.
– volume: 85
  start-page: 348
  year: 2017
  end-page: 354
  ident: CR161
  article-title: Overexpression of the long non-coding RNA SPRY4-IT1 promotes tumor cell proliferation and invasion by activating EZH2 in hepatocellular carcinoma
  publication-title: Biomed. Pharmacother.
– volume: 64
  start-page: 278
  year: 2016
  end-page: 291
  ident: CR104
  article-title: Hepatitis B virus-human chimeric transcript HBx-LINE1 promotes hepatic injury via sequestering cellular microRNA-122
  publication-title: J. Hepatol.
– volume: 6
  start-page: 33791
  year: 2015
  end-page: 33804
  ident: CR99
  article-title: HBx-related long non-coding RNA DBH-AS1 promotes cell proliferation and survival by activating MAPK signaling in hepatocellular carcinoma
  publication-title: Oncotarget
– volume: 58
  start-page: 1165
  year: 2013
  end-page: 1173
  ident: CR34
  article-title: Deep sequencing of small RNA transcriptome reveals novel non-coding RNAs in hepatocellular carcinoma
  publication-title: J. Hepatol.
– volume: 465
  start-page: 1033
  year: 2010
  end-page: 1038
  ident: CR66
  article-title: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
  publication-title: Nature
– volume: 9
  start-page: e101330
  year: 2014
  ident: CR79
  article-title: MicroRNA-122 triggers mesenchymal-epithelial transition and suppresses hepatocellular carcinoma cell motility and invasion by targeting RhoA
  publication-title: PLoS ONE
– volume: 12
  start-page: 138
  year: 1958
  end-page: 163
  ident: CR5
  article-title: On protein synthesis
  publication-title: Symp. Soc. Exp. Biol.
– volume: 12
  start-page: 84
  year: 2012
  end-page: 88
  ident: CR29
  article-title: Are snoRNAs and snoRNA host genes new players in cancer?
  publication-title: Nat. Rev. Cancer
– volume: 48
  start-page: 1810
  year: 2008
  end-page: 1820
  ident: CR118
  article-title: Nonalcoholic steatohepatitis is associated with altered hepatic microRNA expression
  publication-title: Hepatology
– volume: 70
  start-page: 5184
  year: 2010
  end-page: 5193
  ident: CR83
  article-title: MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells
  publication-title: Cancer Res.
– volume: 7
  start-page: 54650
  year: 2016
  end-page: 54661
  ident: CR33
  article-title: Specific patterns of PIWI-interacting small noncoding RNA expression in dysplastic liver nodules and hepatocellular carcinoma
  publication-title: Oncotarget
– volume: 33
  start-page: 4069
  year: 2014
  end-page: 4076
  ident: CR134
  article-title: MicroRNA-148a suppresses the epithelial-mesenchymal transition and metastasis of hepatoma cells by targeting Met/Snail signaling
  publication-title: Oncogene
– volume: 425
  start-page: 415
  year: 2003
  end-page: 419
  ident: CR191
  article-title: The nuclear RNase III Drosha initiates microRNA processing
  publication-title: Nature
– volume: 17
  start-page: 47
  year: 2016
  end-page: 62
  ident: CR35
  article-title: Unique features of long non-coding RNA biogenesis and function
  publication-title: Nat. Rev. Genet.
– volume: 287
  start-page: 26302
  year: 2012
  end-page: 26311
  ident: CR101
  article-title: Elevation of highly up-regulated in liver cancer (HULC) by hepatitis B virus X protein promotes hepatoma cell proliferation via down-regulating p18
  publication-title: J. Biol. Chem.
– volume: 132
  start-page: 2542
  year: 2007
  end-page: 2556
  ident: CR144
  article-title: Identification and characterization of tumorigenic liver cancer stem/progenitor cells
  publication-title: Gastroenterology
– volume: 22
  start-page: 291
  year: 2012
  end-page: 303
  ident: CR138
  article-title: TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma
  publication-title: Cancer Cell
– volume: 57
  start-page: 840
  year: 2013
  end-page: 847
  ident: CR25
  article-title: MicroRNAs: new tools for diagnosis, prognosis, and therapy in hepatocellular carcinoma?
  publication-title: Hepatology
– volume: 452
  start-page: 896
  year: 2008
  end-page: 899
  ident: CR174
  article-title: LNA-mediated microRNA silencing in non-human primates
  publication-title: Nature
– volume: 91
  start-page: 241
  year: 2005
  end-page: 247
  ident: CR93
  article-title: Hit-and-run mechanism of HBV-mediated progression to hepatocellular carcinoma
  publication-title: Tumori
– volume: 75
  start-page: 846
  year: 2015
  end-page: 857
  ident: CR46
  article-title: Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway
  publication-title: Cancer Res.
– volume: 32
  start-page: 4509
  year: 2013
  end-page: 4518
  ident: CR130
  article-title: Thyroid hormone receptor represses miR-17 expression to enhance tumor metastasis in human hepatoma cells
  publication-title: Oncogene
– volume: 62
  start-page: 466
  year: 2015
  end-page: 480
  ident: CR154
  article-title: MicroRNA-494 is a master epigenetic regulator of multiple invasion-suppressor microRNAs by targeting ten eleven translocation 1 in invasive human hepatocellular carcinoma tumors
  publication-title: Hepatology
– volume: 23
  start-page: 631
  year: 2016
  end-page: 639
  ident: CR42
  article-title: lnc-β-Catm elicits EZH2-dependent beta-catenin stabilization and sustains liver CSC self-renewal
  publication-title: Nat. Struct. Mol. Biol.
– volume: 6
  start-page: 37982
  year: 2016
  ident: CR65
  article-title: Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes
  publication-title: Sci. Rep.
– volume: 58
  start-page: 1153
  year: 2013
  end-page: 1165
  ident: CR152
  article-title: miR-148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the invasiveness of transformed cells
  publication-title: Hepatology
– volume: 15
  start-page: 5073
  year: 2009
  end-page: 5081
  ident: CR87
  article-title: MicroRNA-221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality
  publication-title: Clin. Cancer Res.
– volume: 4
  start-page: 19
  year: 2012
  end-page: 37
  ident: CR3
  article-title: Hepatocellular carcinoma: current trends in worldwide epidemiology, risk factors, diagnosis, and therapeutics
  publication-title: Hepat. Med.
– volume: 42
  start-page: D68
  year: 2014
  end-page: D73
  ident: CR9
  article-title: miRBase: annotating high confidence microRNAs using deep sequencing data
  publication-title: Nucleic Acids Res.
– volume: 305
  start-page: 1437
  year: 2004
  end-page: 1441
  ident: CR192
  article-title: Argonaute2 is the catalytic engine of mammalian RNAi
  publication-title: Science
– volume: 1
  start-page: 2
  year: 2015
  end-page: 9
  ident: CR36
  article-title: Conservation and tissue-specific transcription patterns of long noncoding RNAs
  publication-title: J. Hum. Transcr
– volume: 62
  start-page: 1132
  year: 2015
  end-page: 1144
  ident: CR84
  article-title: MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer
  publication-title: Hepatology
– volume: 10
  start-page: 28
  year: 1990
  end-page: 36
  ident: CR193
  article-title: The product of the H19 gene may function as an RNA
  publication-title: Mol. Cell. Biol.
– volume: 57
  start-page: 19
  year: 2006
  end-page: 53
  ident: CR195
  article-title: MicroRNAS and their regulatory roles in plants
  publication-title: Annu. Rev. Plant Biol.
– volume: 133
  start-page: 647
  year: 2007
  end-page: 658
  ident: CR15
  article-title: MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
  publication-title: Gastroenterology
– volume: 40
  start-page: D912
  year: 2012
  end-page: D917
  ident: CR6
  article-title: ENCODE whole-genome data in the UCSC Genome Browser: update 2012
  publication-title: Nucleic Acids Res.
– volume: 7
  start-page: e30733
  year: 2012
  ident: CR61
  article-title: Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types
  publication-title: PLoS ONE
– volume: 7
  start-page: 17021
  year: 2016
  end-page: 17034
  ident: CR73
  article-title: Chronic inflammation contributes to the development of hepatocellular carcinoma by decreasing miR-122 levels
  publication-title: Oncotarget
– ident: CR180
– volume: 283
  start-page: 3739
  year: 2016
  end-page: 3754
  ident: CR55
  article-title: Long noncoding RNA glypican 3 (GPC3) antisense transcript 1 promotes hepatocellular carcinoma progression via epigenetically activating GPC3
  publication-title: FEBS J.
– volume: 56
  start-page: 1025
  year: 2012
  end-page: 1033
  ident: CR90
  article-title: Liver tumorigenicity promoted by microRNA-221 in a mouse transgenic model
  publication-title: Hepatology
– volume: 19
  start-page: 349
  year: 1966
  end-page: 361
  ident: CR185
  article-title: Rapidly labeled HeLa cell nuclear RNA. I. Identif. Zone
  publication-title: J. Mol. Biol.
– volume: 16
  start-page: 413
  year: 2015
  end-page: 425
  ident: CR40
  article-title: The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling
  publication-title: Cell Stem Cell
– volume: 54
  start-page: 1679
  year: 2011
  end-page: 1689
  ident: CR160
  article-title: Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans
  publication-title: Hepatology
– volume: 17
  start-page: 487
  year: 2016
  end-page: 500
  ident: CR150
  article-title: The molecular hallmarks of epigenetic control
  publication-title: Nat. Rev. Genet.
– volume: 62
  start-page: 1723
  year: 2015
  end-page: 1730
  ident: CR2
  article-title: Association of nonalcoholic fatty liver disease (NAFLD) with hepatocellular carcinoma (HCC) in the United States from 2004 to 2009
  publication-title: Hepatology
– volume: 109
  start-page: 941
  year: 2012
  end-page: 946
  ident: CR106
  article-title: Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex
  publication-title: Proc. Natl Acad. Sci. USA
– volume: 368
  start-page: 1685
  year: 2013
  end-page: 1694
  ident: CR177
  article-title: Treatment of HCV infection by targeting microRNA
  publication-title: N. Engl. J. Med.
– volume: 69
  start-page: 1135
  year: 2009
  end-page: 1142
  ident: CR20
  article-title: MicroRNA-101, down-regulated in hepatocellular carcinoma, promotes apoptosis and suppresses tumorigenicity
  publication-title: Cancer Res.
– volume: 108
  start-page: 3193
  year: 2011
  end-page: 3198
  ident: CR110
  article-title: Masking the 5′ terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex
  publication-title: Proc. Natl Acad. Sci. USA
– volume: 64
  start-page: 897
  year: 1995
  end-page: 934
  ident: CR188
  article-title: The small nucleolar RNAs
  publication-title: Annu. Rev. Biochem.
– volume: 54
  start-page: 1177
  year: 2011
  end-page: 1184
  ident: CR22
  article-title: Deregulation of microRNA expression occurs early and accumulates in early stages of HBV-associated multistep hepatocarcinogenesis
  publication-title: J. Hepatol.
– volume: 9
  start-page: 243
  year: 2017
  end-page: 255
  ident: CR31
  article-title: SNORD126 promotes HCC and CRC cell growth by activating the PI3K-AKT pathway through FGFR2
  publication-title: J. Mol. Cell Biol.
– volume: 105
  start-page: 146
  year: 2011
  ident: BFnrgastro2017169_CR96
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.2011.190
– volume: 23
  start-page: 631
  year: 2016
  ident: BFnrgastro2017169_CR42
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.3235
– volume: 305
  start-page: 1437
  year: 2004
  ident: BFnrgastro2017169_CR192
  publication-title: Science
  doi: 10.1126/science.1102513
– volume: 64
  start-page: 800
  year: 2015
  ident: BFnrgastro2017169_CR119
  publication-title: Gut
  doi: 10.1136/gutjnl-2014-306996
– volume: 32
  start-page: 752
  year: 2012
  ident: BFnrgastro2017169_CR80
  publication-title: Liver Int.
  doi: 10.1111/j.1478-3231.2011.02750.x
– volume: 62
  start-page: 1723
  year: 2015
  ident: BFnrgastro2017169_CR2
  publication-title: Hepatology
  doi: 10.1002/hep.28123
– volume: 27
  start-page: 390
  year: 2013
  ident: BFnrgastro2017169_CR198
  publication-title: Genes Dev.
  doi: 10.1101/gad.209841.112
– volume: 70
  start-page: 9798
  year: 2010
  ident: BFnrgastro2017169_CR163
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-10-1001
– volume: 22
  start-page: 894
  year: 2008
  ident: BFnrgastro2017169_CR137
  publication-title: Genes Dev.
  doi: 10.1101/gad.1640608
– volume: 136
  start-page: 1012
  year: 2009
  ident: BFnrgastro2017169_CR145
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2008.12.004
– volume: 7
  start-page: 694
  year: 2010
  ident: BFnrgastro2017169_CR146
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2010.11.010
– volume: 283
  start-page: 3739
  year: 2016
  ident: BFnrgastro2017169_CR55
  publication-title: FEBS J.
  doi: 10.1111/febs.13839
– volume: 62
  start-page: 1132
  year: 2015
  ident: BFnrgastro2017169_CR84
  publication-title: Hepatology
  doi: 10.1002/hep.27929
– volume: 56
  start-page: 1371
  year: 2012
  ident: BFnrgastro2017169_CR26
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2011.11.026
– volume: 63
  start-page: 474
  year: 2016
  ident: BFnrgastro2017169_CR155
  publication-title: Hepatology
  doi: 10.1002/hep.28304
– volume: 414
  start-page: 105
  year: 2001
  ident: BFnrgastro2017169_CR143
  publication-title: Nature
  doi: 10.1038/35102167
– volume: 35
  start-page: 1597
  year: 2015
  ident: BFnrgastro2017169_CR38
  publication-title: Liver Int.
  doi: 10.1111/liv.12746
– volume: 69
  start-page: 1135
  year: 2009
  ident: BFnrgastro2017169_CR20
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-08-2886
– volume: 6
  start-page: 35531
  year: 2016
  ident: BFnrgastro2017169_CR124
  publication-title: Sci. Rep.
  doi: 10.1038/srep35531
– volume: 409
  start-page: 363
  year: 2001
  ident: BFnrgastro2017169_CR190
  publication-title: Nature
  doi: 10.1038/35053110
– volume: 6
  start-page: 13658
  year: 2015
  ident: BFnrgastro2017169_CR129
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.3700
– volume: 473
  start-page: 1268
  year: 2016
  ident: BFnrgastro2017169_CR57
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2016.04.054
– volume: 15
  start-page: 509
  year: 2014
  ident: BFnrgastro2017169_CR10
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3838
– volume: 140
  start-page: 322
  year: 2011
  ident: BFnrgastro2017169_CR127
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2010.10.006
– volume: 35
  start-page: 240
  year: 2015
  ident: BFnrgastro2017169_CR132
  publication-title: Liver Int.
  doi: 10.1111/liv.12517
– volume: 69
  start-page: 5761
  year: 2009
  ident: BFnrgastro2017169_CR78
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-08-4797
– volume: 71
  start-page: 7608
  year: 2011
  ident: BFnrgastro2017169_CR175
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-11-1144
– volume: 8
  start-page: 3683
  year: 2017
  ident: BFnrgastro2017169_CR171
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.12465
– volume: 25
  start-page: 335
  year: 2014
  ident: BFnrgastro2017169_CR103
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2014.01.030
– volume: 34
  start-page: 577
  year: 2013
  ident: BFnrgastro2017169_CR142
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgs381
– volume: 56
  start-page: 1025
  year: 2012
  ident: BFnrgastro2017169_CR90
  publication-title: Hepatology
  doi: 10.1002/hep.25747
– volume: 64
  start-page: 1283
  year: 2016
  ident: BFnrgastro2017169_CR149
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2016.01.019
– volume: 5
  start-page: 49
  year: 2013
  ident: BFnrgastro2017169_CR24
  publication-title: Front. Biosci.
  doi: 10.2741/E595
– volume: 17
  start-page: 487
  year: 2016
  ident: BFnrgastro2017169_CR150
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg.2016.59
– volume: 11
  start-page: e1004873
  year: 2015
  ident: BFnrgastro2017169_CR179
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1004873
– volume: 15
  start-page: 5073
  year: 2009
  ident: BFnrgastro2017169_CR87
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-09-0092
– volume: 6
  start-page: 23521
  year: 2016
  ident: BFnrgastro2017169_CR100
  publication-title: Sci. Rep.
  doi: 10.1038/srep23521
– volume: 464
  start-page: 1071
  year: 2010
  ident: BFnrgastro2017169_CR47
  publication-title: Nature
  doi: 10.1038/nature08975
– volume: 438
  start-page: 685
  year: 2005
  ident: BFnrgastro2017169_CR71
  publication-title: Nature
  doi: 10.1038/nature04303
– volume: 349
  start-page: 87
  year: 2014
  ident: BFnrgastro2017169_CR56
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2014.03.029
– volume: 59
  start-page: 1354
  year: 2013
  ident: BFnrgastro2017169_CR172
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2013.05.045
– volume: 16
  start-page: 413
  year: 2015
  ident: BFnrgastro2017169_CR40
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2015.03.003
– volume: 55
  start-page: 108
  year: 2012
  ident: BFnrgastro2017169_CR95
  publication-title: Hepatology
  doi: 10.1002/hep.24675
– volume: 61
  start-page: 278
  year: 2012
  ident: BFnrgastro2017169_CR126
  publication-title: Gut
  doi: 10.1136/gut.2011.239145
– volume: 12
  start-page: 84
  year: 2012
  ident: BFnrgastro2017169_CR29
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc3195
– volume: 27
  start-page: 5651
  year: 2008
  ident: BFnrgastro2017169_CR86
  publication-title: Oncogene
  doi: 10.1038/onc.2008.178
– volume: 31
  start-page: 147
  year: 1982
  ident: BFnrgastro2017169_CR187
  publication-title: Cell
  doi: 10.1016/0092-8674(82)90414-7
– volume: 133
  start-page: 647
  year: 2007
  ident: BFnrgastro2017169_CR15
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2007.05.022
– volume: 64
  start-page: 156
  year: 2015
  ident: BFnrgastro2017169_CR148
  publication-title: Gut
  doi: 10.1136/gutjnl-2013-305715
– volume: 32
  start-page: 309
  year: 2016
  ident: BFnrgastro2017169_CR59
  publication-title: Trends Genet.
  doi: 10.1016/j.tig.2016.03.002
– volume: 13
  start-page: 216
  year: 2014
  ident: BFnrgastro2017169_CR30
  publication-title: Mol. Cancer
  doi: 10.1186/1476-4598-13-216
– volume: 406
  start-page: 70
  year: 2011
  ident: BFnrgastro2017169_CR88
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2011.01.111
– volume: 99
  start-page: 671
  year: 2006
  ident: BFnrgastro2017169_CR74
  publication-title: J. Cell. Biochem.
  doi: 10.1002/jcb.20982
– volume: 52
  start-page: 1731
  year: 2010
  ident: BFnrgastro2017169_CR19
  publication-title: Hepatology
  doi: 10.1002/hep.23904
– volume: 57
  start-page: 840
  year: 2013
  ident: BFnrgastro2017169_CR25
  publication-title: Hepatology
  doi: 10.1002/hep.26095
– volume: 137
  start-page: 1005
  year: 2009
  ident: BFnrgastro2017169_CR178
  publication-title: Cell
  doi: 10.1016/j.cell.2009.04.021
– volume: 128
  start-page: 1089
  year: 2007
  ident: BFnrgastro2017169_CR197
  publication-title: Cell
  doi: 10.1016/j.cell.2007.01.043
– volume: 6
  start-page: 37982
  year: 2016
  ident: BFnrgastro2017169_CR65
  publication-title: Sci. Rep.
  doi: 10.1038/srep37982
– volume: 22
  start-page: 1775
  year: 2012
  ident: BFnrgastro2017169_CR7
  publication-title: Genome Res.
  doi: 10.1101/gr.132159.111
– volume: 118
  start-page: 3030
  year: 2006
  ident: BFnrgastro2017169_CR92
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.21731
– ident: BFnrgastro2017169_CR166
– volume: 21
  start-page: 455
  year: 2015
  ident: BFnrgastro2017169_CR123
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2015.02.004
– volume: 7
  start-page: e30733
  year: 2012
  ident: BFnrgastro2017169_CR61
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0030733
– volume: 449
  start-page: 919
  year: 2007
  ident: BFnrgastro2017169_CR113
  publication-title: Nature
  doi: 10.1038/nature06205
– volume: 132
  start-page: 2542
  year: 2007
  ident: BFnrgastro2017169_CR144
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2007.04.025
– volume: 54
  start-page: 1177
  year: 2011
  ident: BFnrgastro2017169_CR22
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2010.09.023
– volume: 11
  start-page: e0158347
  year: 2016
  ident: BFnrgastro2017169_CR63
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0158347
– volume: 127
  start-page: 761
  year: 2017
  ident: BFnrgastro2017169_CR184
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI84424
– volume: 16
  start-page: 867
  year: 2010
  ident: BFnrgastro2017169_CR17
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-09-1840
– volume: 4
  start-page: 19
  year: 2012
  ident: BFnrgastro2017169_CR3
  publication-title: Hepat. Med.
– volume: 57
  start-page: 19
  year: 2006
  ident: BFnrgastro2017169_CR195
  publication-title: Annu. Rev. Plant Biol.
  doi: 10.1146/annurev.arplant.57.032905.105218
– volume: 327
  start-page: 198
  year: 2010
  ident: BFnrgastro2017169_CR176
  publication-title: Science
  doi: 10.1126/science.1178178
– volume: 9
  start-page: 243
  year: 2017
  ident: BFnrgastro2017169_CR31
  publication-title: J. Mol. Cell Biol.
  doi: 10.1093/jmcb/mjx043
– volume: 9
  start-page: e115036
  year: 2014
  ident: BFnrgastro2017169_CR77
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0115036
– volume: 129
  start-page: 1311
  year: 2007
  ident: BFnrgastro2017169_CR50
  publication-title: Cell
  doi: 10.1016/j.cell.2007.05.022
– volume: 35
  start-page: 1575
  year: 2016
  ident: BFnrgastro2017169_CR54
  publication-title: Oncogene
  doi: 10.1038/onc.2015.223
– volume: 287
  start-page: 26302
  year: 2012
  ident: BFnrgastro2017169_CR101
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M112.342113
– volume: 62
  start-page: 466
  year: 2015
  ident: BFnrgastro2017169_CR154
  publication-title: Hepatology
  doi: 10.1002/hep.27816
– volume-title: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics
  year: 2015
  ident: BFnrgastro2017169_CR181
– volume: 168
  start-page: 134
  year: 2016
  ident: BFnrgastro2017169_CR169
  publication-title: Transl Res.
  doi: 10.1016/j.trsl.2015.10.002
– volume: 7
  start-page: 241
  year: 2016
  ident: BFnrgastro2017169_CR44
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.6280
– volume: 6
  start-page: 33791
  year: 2015
  ident: BFnrgastro2017169_CR99
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.5667
– volume: 7
  start-page: 42431
  year: 2016
  ident: BFnrgastro2017169_CR45
  publication-title: Oncotarget
– volume: 6
  start-page: 7466
  year: 2015
  ident: BFnrgastro2017169_CR121
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms8466
– volume: 7
  start-page: 13608
  year: 2016
  ident: BFnrgastro2017169_CR41
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms13608
– volume: 91
  start-page: 241
  year: 2005
  ident: BFnrgastro2017169_CR93
  publication-title: Tumori
  doi: 10.1177/030089160509100306
– volume: 57
  start-page: 1882
  year: 2013
  ident: BFnrgastro2017169_CR102
  publication-title: Hepatology
  doi: 10.1002/hep.26195
– volume: 58
  start-page: 1153
  year: 2013
  ident: BFnrgastro2017169_CR152
  publication-title: Hepatology
  doi: 10.1002/hep.26422
– volume: 134
  start-page: 610
  year: 2008
  ident: BFnrgastro2017169_CR196
  publication-title: Cell
  doi: 10.1016/j.cell.2008.06.052
– volume: 40
  start-page: D912
  year: 2012
  ident: BFnrgastro2017169_CR6
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkr1012
– volume: 64
  start-page: 897
  year: 1995
  ident: BFnrgastro2017169_CR188
  publication-title: Annu. Rev. Biochem.
  doi: 10.1146/annurev.bi.64.070195.004341
– volume: 70
  start-page: 5184
  year: 2010
  ident: BFnrgastro2017169_CR83
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-10-0145
– volume: 58
  start-page: 629
  year: 2013
  ident: BFnrgastro2017169_CR133
  publication-title: Hepatology
  doi: 10.1002/hep.26369
– volume: 58
  start-page: 1165
  year: 2013
  ident: BFnrgastro2017169_CR34
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2013.01.032
– volume: 64
  start-page: 278
  year: 2016
  ident: BFnrgastro2017169_CR104
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2015.09.013
– volume: 10
  start-page: 925
  year: 2013
  ident: BFnrgastro2017169_CR37
  publication-title: RNA Biol.
– volume: 110
  start-page: 1881
  year: 2013
  ident: BFnrgastro2017169_CR107
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1213515110
– volume: 452
  start-page: 896
  year: 2008
  ident: BFnrgastro2017169_CR174
  publication-title: Nature
  doi: 10.1038/nature06783
– volume: 351
  start-page: 329
  year: 1991
  ident: BFnrgastro2017169_CR194
  publication-title: Nature
  doi: 10.1038/351329a0
– volume: 12
  start-page: 138
  year: 1958
  ident: BFnrgastro2017169_CR5
  publication-title: Symp. Soc. Exp. Biol.
– volume: 49
  start-page: 1098
  year: 2009
  ident: BFnrgastro2017169_CR105
  publication-title: Hepatology
  doi: 10.1002/hep.22749
– volume: 73
  start-page: 1180
  year: 2013
  ident: BFnrgastro2017169_CR183
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-12-2850
– volume: 67
  start-page: 6092
  year: 2007
  ident: BFnrgastro2017169_CR18
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-06-4607
– volume: 495
  start-page: 333
  year: 2013
  ident: BFnrgastro2017169_CR62
  publication-title: Nature
  doi: 10.1038/nature11928
– volume: 210
  start-page: 789
  year: 2013
  ident: BFnrgastro2017169_CR135
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20120153
– volume: 472
  start-page: 120
  year: 2011
  ident: BFnrgastro2017169_CR52
  publication-title: Nature
  doi: 10.1038/nature09819
– volume: 75
  start-page: 3181
  year: 2015
  ident: BFnrgastro2017169_CR58
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-14-3721
– volume: 44
  start-page: 71
  year: 2015
  ident: BFnrgastro2017169_CR68
  publication-title: Biomaterials
  doi: 10.1016/j.biomaterials.2014.12.023
– volume: 64
  start-page: 1256
  year: 2016
  ident: BFnrgastro2017169_CR94
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2016.02.005
– volume: 7
  start-page: 54650
  year: 2016
  ident: BFnrgastro2017169_CR33
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.10567
– volume: 74
  start-page: 3171
  year: 1977
  ident: BFnrgastro2017169_CR186
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.74.8.3171
– volume: 8
  start-page: 14421
  year: 2017
  ident: BFnrgastro2017169_CR39
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms14421
– volume: 19
  start-page: 349
  year: 1966
  ident: BFnrgastro2017169_CR185
  publication-title: J. Mol. Biol.
  doi: 10.1016/S0022-2836(66)80009-8
– volume: 44
  start-page: 1370
  year: 2016
  ident: BFnrgastro2017169_CR64
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkv1367
– volume: 10
  start-page: 627
  year: 2013
  ident: BFnrgastro2017169_CR116
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/nrgastro.2013.149
– volume: 54
  start-page: 1729
  year: 2011
  ident: BFnrgastro2017169_CR131
  publication-title: Hepatology
  doi: 10.1002/hep.24577
– volume: 25
  start-page: 2537
  year: 2006
  ident: BFnrgastro2017169_CR13
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1209283
– volume: 160
  start-page: 1099
  year: 2015
  ident: BFnrgastro2017169_CR111
  publication-title: Cell
  doi: 10.1016/j.cell.2015.02.025
– volume: 7
  start-page: 17021
  year: 2016
  ident: BFnrgastro2017169_CR73
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.7740
– volume: 50
  start-page: 453
  year: 2009
  ident: BFnrgastro2017169_CR112
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2008.06.010
– volume: 33
  start-page: 4069
  year: 2014
  ident: BFnrgastro2017169_CR134
  publication-title: Oncogene
  doi: 10.1038/onc.2013.369
– volume: 52
  start-page: 60
  year: 2010
  ident: BFnrgastro2017169_CR153
  publication-title: Hepatology
  doi: 10.1002/hep.23660
– volume: 2013
  start-page: 136106
  year: 2013
  ident: BFnrgastro2017169_CR168
  publication-title: Biomed. Res. Int.
– ident: BFnrgastro2017169_CR122
  doi: 10.1136/gutjnl-2016-312869
– volume: 425
  start-page: 415
  year: 2003
  ident: BFnrgastro2017169_CR191
  publication-title: Nature
  doi: 10.1038/nature01957
– volume: 17
  start-page: 47
  year: 2016
  ident: BFnrgastro2017169_CR35
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg.2015.10
– volume: 75
  start-page: 846
  year: 2015
  ident: BFnrgastro2017169_CR46
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-14-1192
– volume: 309
  start-page: 1577
  year: 2005
  ident: BFnrgastro2017169_CR108
  publication-title: Science
  doi: 10.1126/science.1113329
– ident: BFnrgastro2017169_CR180
– volume: 64
  start-page: 1623
  year: 2016
  ident: BFnrgastro2017169_CR81
  publication-title: Hepatology
  doi: 10.1002/hep.28679
– volume: 34
  start-page: 2671
  year: 2015
  ident: BFnrgastro2017169_CR85
  publication-title: EMBO J.
  doi: 10.15252/embj.201591803
– volume: 57
  start-page: 637
  year: 2013
  ident: BFnrgastro2017169_CR156
  publication-title: Hepatology
  doi: 10.1002/hep.26083
– ident: BFnrgastro2017169_CR167
– volume: 94
  start-page: 1281
  year: 2016
  ident: BFnrgastro2017169_CR141
  publication-title: J. Mol. Med.
  doi: 10.1007/s00109-016-1442-z
– volume: 75
  start-page: 843
  year: 1993
  ident: BFnrgastro2017169_CR189
  publication-title: Cell
  doi: 10.1016/0092-8674(93)90529-Y
– volume: 42
  start-page: D68
  year: 2014
  ident: BFnrgastro2017169_CR9
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkt1181
– volume: 63
  start-page: 1560
  year: 2016
  ident: BFnrgastro2017169_CR139
  publication-title: Hepatology
  doi: 10.1002/hep.28445
– volume: 71
  start-page: 6320
  year: 2011
  ident: BFnrgastro2017169_CR48
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-11-1021
– volume: 22
  start-page: 291
  year: 2012
  ident: BFnrgastro2017169_CR138
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2012.07.023
– volume: 14
  start-page: 165
  year: 2015
  ident: BFnrgastro2017169_CR162
  publication-title: Mol. Cancer
  doi: 10.1186/s12943-015-0431-0
– volume: 62
  start-page: 829
  year: 2015
  ident: BFnrgastro2017169_CR147
  publication-title: Hepatology
  doi: 10.1002/hep.27886
– volume: 23
  start-page: 3953
  year: 2017
  ident: BFnrgastro2017169_CR91
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-16-1464
– volume: 48
  start-page: 1810
  year: 2008
  ident: BFnrgastro2017169_CR118
  publication-title: Hepatology
  doi: 10.1002/hep.22569
– volume: 34
  start-page: 1773
  year: 2013
  ident: BFnrgastro2017169_CR69
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgt139
– volume: 53
  start-page: 57
  year: 2010
  ident: BFnrgastro2017169_CR21
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2009.12.043
– volume: 28
  start-page: 160
  year: 2008
  ident: BFnrgastro2017169_CR4
  publication-title: Liver Int.
  doi: 10.1111/j.1478-3231.2007.01637.x
– volume: 142
  start-page: 1431
  year: 2012
  ident: BFnrgastro2017169_CR28
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2012.04.007
– volume: 28
  start-page: 3526
  year: 2009
  ident: BFnrgastro2017169_CR75
  publication-title: Oncogene
  doi: 10.1038/onc.2009.211
– volume: 122
  start-page: 2871
  year: 2012
  ident: BFnrgastro2017169_CR72
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI63539
– volume: 122
  start-page: 2884
  year: 2012
  ident: BFnrgastro2017169_CR120
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI63455
– volume: 55
  start-page: 1453
  year: 2012
  ident: BFnrgastro2017169_CR23
  publication-title: Hepatology
  doi: 10.1002/hep.25512
– volume: 50
  start-page: 2560
  year: 2014
  ident: BFnrgastro2017169_CR98
  publication-title: Eur. J. Cancer
  doi: 10.1016/j.ejca.2014.07.008
– volume: 107
  start-page: 264
  year: 2010
  ident: BFnrgastro2017169_CR16
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0907904107
– volume: 18
  start-page: 1243
  year: 2011
  ident: BFnrgastro2017169_CR49
  publication-title: Ann. Surg. Oncol.
  doi: 10.1245/s10434-011-1581-y
– volume: 16
  start-page: 421
  year: 2015
  ident: BFnrgastro2017169_CR8
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg3965
– volume: 32
  start-page: 4509
  year: 2013
  ident: BFnrgastro2017169_CR130
  publication-title: Oncogene
  doi: 10.1038/onc.2013.309
– volume: 29
  start-page: 4781
  year: 2011
  ident: BFnrgastro2017169_CR164
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2011.38.2697
– volume: 63
  start-page: 886
  year: 2015
  ident: BFnrgastro2017169_CR51
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2015.05.016
– volume: 9
  start-page: 137
  year: 2012
  ident: BFnrgastro2017169_CR70
  publication-title: RNA Biol.
  doi: 10.4161/rna.18827
– volume: 15
  start-page: 423
  year: 2014
  ident: BFnrgastro2017169_CR151
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg3722
– volume: 85
  start-page: 348
  year: 2017
  ident: BFnrgastro2017169_CR161
  publication-title: Biomed. Pharmacother.
  doi: 10.1016/j.biopha.2016.11.035
– volume: 14
  start-page: 419
  year: 2008
  ident: BFnrgastro2017169_CR14
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-07-0523
– volume: 110
  start-page: 1571
  year: 2013
  ident: BFnrgastro2017169_CR109
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1220841110
– volume: 109
  start-page: 941
  year: 2012
  ident: BFnrgastro2017169_CR106
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1112263109
– volume: 108
  start-page: 3193
  year: 2011
  ident: BFnrgastro2017169_CR110
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1012464108
– volume: 2
  start-page: E98
  year: 2004
  ident: BFnrgastro2017169_CR173
  publication-title: PLoS Biol.
  doi: 10.1371/journal.pbio.0020098
– volume: 8
  start-page: 50
  year: 2015
  ident: BFnrgastro2017169_CR159
  publication-title: J. Hematol. Oncol.
  doi: 10.1186/s13045-015-0153-1
– volume: 61
  start-page: 69
  year: 2011
  ident: BFnrgastro2017169_CR1
  publication-title: CA Cancer J. Clin.
  doi: 10.3322/caac.20107
– volume: 66
  start-page: 794
  year: 2017
  ident: BFnrgastro2017169_CR125
  publication-title: Hepatology
  doi: 10.1002/hep.29034
– volume: 59
  start-page: 911
  year: 2014
  ident: BFnrgastro2017169_CR53
  publication-title: Hepatology
  doi: 10.1002/hep.26740
– volume: 68
  start-page: 5049
  year: 2008
  ident: BFnrgastro2017169_CR157
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-07-6655
– volume: 66
  start-page: 734
  year: 2017
  ident: BFnrgastro2017169_CR12
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2016.12.010
– volume: 132
  start-page: 330
  year: 2007
  ident: BFnrgastro2017169_CR43
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2006.08.026
– volume: 25
  start-page: 666
  year: 2014
  ident: BFnrgastro2017169_CR140
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2014.03.010
– volume: 123
  start-page: 630
  year: 2013
  ident: BFnrgastro2017169_CR97
  publication-title: J. Clin. Invest.
– ident: BFnrgastro2017169_CR165
  doi: 10.18632/oncotarget.9429
– volume: 6
  start-page: 4505
  year: 2015
  ident: BFnrgastro2017169_CR170
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.2934
– volume: 368
  start-page: 1685
  year: 2013
  ident: BFnrgastro2017169_CR177
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1209026
– volume: 56
  start-page: 622
  year: 2012
  ident: BFnrgastro2017169_CR158
  publication-title: Hepatology
  doi: 10.1002/hep.25679
– volume: 6
  start-page: 5666
  year: 2015
  ident: BFnrgastro2017169_CR67
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.3290
– volume: 56
  start-page: 1631
  year: 2012
  ident: BFnrgastro2017169_CR114
  publication-title: Hepatology
  doi: 10.1002/hep.25849
– volume: 10
  start-page: 656
  year: 2013
  ident: BFnrgastro2017169_CR117
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/nrgastro.2013.183
– volume: 9
  start-page: e101330
  year: 2014
  ident: BFnrgastro2017169_CR79
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0101330
– volume: 7
  start-page: 73257
  year: 2016
  ident: BFnrgastro2017169_CR182
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.12304
– volume: 1
  start-page: 2
  year: 2015
  ident: BFnrgastro2017169_CR36
  publication-title: J. Hum. Transcr
  doi: 10.3109/23324015.2015.1077591
– volume: 465
  start-page: 1033
  year: 2010
  ident: BFnrgastro2017169_CR66
  publication-title: Nature
  doi: 10.1038/nature09144
– volume: 54
  start-page: 1679
  year: 2011
  ident: BFnrgastro2017169_CR160
  publication-title: Hepatology
  doi: 10.1002/hep.24563
– volume: 10
  start-page: 28
  year: 1990
  ident: BFnrgastro2017169_CR193
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.10.1.28
– volume: 19
  start-page: 232
  year: 2011
  ident: BFnrgastro2017169_CR82
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2011.01.001
– volume: 9
  start-page: 582
  year: 2008
  ident: BFnrgastro2017169_CR136
  publication-title: EMBO Rep.
  doi: 10.1038/embor.2008.74
– volume: 19
  start-page: 141
  year: 2013
  ident: BFnrgastro2017169_CR60
  publication-title: RNA
  doi: 10.1261/rna.035667.112
– volume: 6
  start-page: 43770
  year: 2015
  ident: BFnrgastro2017169_CR115
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.6087
– volume: 12
  start-page: 390
  year: 2010
  ident: BFnrgastro2017169_CR128
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2039
– volume: 46
  start-page: 391
  year: 2016
  ident: BFnrgastro2017169_CR27
  publication-title: Hepatol. Res.
  doi: 10.1111/hepr.12606
– volume: 12
  start-page: 246
  year: 2011
  ident: BFnrgastro2017169_CR32
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3089
– volume: 59
  start-page: 555
  year: 2014
  ident: BFnrgastro2017169_CR76
  publication-title: Hepatology
  doi: 10.1002/hep.26712
– volume: 16
  start-page: 498
  year: 2009
  ident: BFnrgastro2017169_CR89
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2009.10.014
– volume: 104
  start-page: 543
  year: 2013
  ident: BFnrgastro2017169_CR11
  publication-title: Cancer Sci.
  doi: 10.1111/cas.12126
SSID ssj0065539
Score 2.6344357
SecondaryResourceType review_article
Snippet Key Points Protein-coding sequence accounts for only 2% of the human genome, with the function of the remaining 98% of non-coding sequences in the human genome...
Hepatocellular carcinoma (HCC) is a leading lethal malignancy worldwide. However, the molecular mechanisms underlying liver carcinogenesis remain poorly...
SourceID proquest
gale
pubmed
crossref
springer
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 137
SubjectTerms 631/337/176
631/337/384
631/337/384/331
692/4020/4021/1607/1610
Biomedicine
Carcinogenesis
Care and treatment
Deoxyribonucleic acid
Development and progression
DNA
Gastroenterology
Gene expression
Gene regulation
Genetic aspects
Health aspects
Hepatocellular carcinoma
Hepatology
Hepatoma
Liver cancer
Malignancy
Medicine & Public Health
Mesenchyme
Metastases
MicroRNAs
miRNA
Molecular modelling
Next-generation sequencing
Oncogenes
Post-transcription
review-article
Therapeutic applications
Transcription activation
Tumors
Title Non-coding RNAs in hepatocellular carcinoma: molecular functions and pathological implications
URI https://link.springer.com/article/10.1038/nrgastro.2017.169
https://www.ncbi.nlm.nih.gov/pubmed/29317776
https://www.proquest.com/docview/2023384525
https://www.proquest.com/docview/1989555013
Volume 15
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfR1rS9xAcGgVSr8U-45Vu4VCoSU0j91s4he5FkUKHkUq3Kcu-zor1I1e4v_vTF56Qv0W2NkkOzuz89wZgI8crTWT-CrOCp_H3GY8rpYFJTtILrRxNumui53Mi-Mz_mMhFoPDrRnSKsczsTuoXW3JR05GOlpTFIU7uLqOqWsURVeHFhqPYZNKlxFVy8VkcBVCdJ3EUEJWsUDdZYxq5uXXsDrXTbui638puViqNbl0_3S-I57uxUs7MXS0Bc8G_ZHN-g1_Do98eAFPToYI-Uv4Pa9DbGuSSOx0PmvYRWB_UOS0NbnoKeeUWWofFOpLvc8ux-a4jORbR4JMB8eoT_F4KrKLO0nnr-Ds6PDX9-N46KEQW5EXbWxRg5FSS2QGJ7mpeCGy0qGSatPMycznwvDKa5Hq0maFTVziNPdLqsO1dKVO8tewEerg3wLLMmNMYZYmQR42mTQ85Q4fdFVyL1wVQTJiUNmhwDj1ufirukB3XqoR6YqQrhDpEXyeplz11TUeAn5P26L6C6ITZ6oZrkgIiYpVBJ86COJN_LLVwxUD_H-qcrUGubMGiTxl14fHrVcDTzfqlgIj-DAN00zKUwu-vmkUZaAJNPrSPII3PclMC0PFKpVSFhF8GWno9uX_XfX2w7_yDp4iZNlnxe3ARru68buoJrVmr-OFPdj8djj_efoPy8ASTQ
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3da9RAEB9qBfVF_DZa7QqKoASTzW42EUQOtVxt7x6khXty3a-zhTapd1fEf8q_0Zl8XHsF-9a3wO4mu7Oz85vJzOwAvBRordkklDHPQxYLx0VcTnMKdlBCGutd0qSLjcb5cF98ncjJGvztc2EorLKXiY2g9rWjf-RkpKM1RV64jye_YqoaRd7VvoRGyxY74c9vNNnmH7Y_4_6-4nzry96nYdxVFYidzPJF7BDTlTIK2cMrYUuRS154VNtcyr3iIZNWlMHI1BSO5y7xiTciTOlmqqkvTJLhe6_BdQTehIw9NVkaeLmUTeUyROQylqgr9V7UrHhXzX6a-WJG6YYp_dIpV3DwIhqcg8ML_tkG9rbuwO1OX2WDlsHuwlqo7sGNUeeRvw_fx3UVu5oQkH0bD-bssGIHCHGLmlwCFOPKHJUrqupj854d98V4GeFpw_LMVJ5RXeReCrPDc0HuD2D_Sqj7ENarugqPgXFurc3t1CYoMyxXVqTC44MpCxGkLyNIegpq111oTnU1jnTjWM8K3RNdE9E1Ej2CN8shJ-1tHpd13qRt0W1C6lIS6AGuSEqFilwEr5seJAvwy850KQ04f7pVa6XnxkpPPMNutbnfet3JkLk-4_gIXiybaSTFxVWhPp1riniTaGSmWQSPWpZZLgwVuVQplUfwtuehs5f_d9VPLp_KJtwc7o129e72eOcp3MJRRRuRtwHri9lpeIYq2sI-b84Fgx9XfRD_AQyMTMQ
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3da9RAEB_qFYov4rfRaldQBCU02exmE0HktC2ttUcpFvrkuh85Ldik3l0R_zX_OmeS7LVXsG99C2Q3yc7OzG8mM7MD8EKgt2aTqox5XmWxcFzE5TinZAclpLHeJW252N4o3z4Un47k0RL8DbUwlFYZdGKrqH3j6B85OenoTVEUbn3cp0Xsb2y9P_0VUwcpirSGdhodi-xWf36j-zZ9t7OBe_2S863NLx-3477DQOxkls9ih_iulFHIKl4JW4pc8sKjCedS7hWvMmlFWRmZmsLx3CU-8UZUYzqlauwLk2T43BuwrMgrGsDyh83R_kHAgVzKto8Z4nMZS7ScQkw1K9bryXcznU2o-DClHzzlAipexoYL4HgpWtuC4NZtuNVbr2zYsdsdWKrqu7Cy18fn78HXUVPHriE8ZAej4ZQd1-wHAt6soQABZbwyR82L6ubEvGUnoTUvI3RtBYCZ2jPqkhx0Mju-kPJ-Hw6vhb4PYFA3dfUIGOfW2tyObYIaxHJlRSo8XpiyEJX0ZQRJoKB2_fHm1GXjp27D7FmhA9E1EV0j0SN4PZ9y2p3tcdXgNdoW3ZWnzvWCHuKKpFRo1kXwqh1BmgHf7Exf4IDfT2dsLYxcXRiJEu0Wb4et171Gmepz_o_g-fw2zaQsubpqzqaa8t8kupxpFsHDjmXmC0OzLlVK5RG8CTx0_vD_rvrx1Z-yBisohPrzzmj3CdzESUWXnrcKg9nkrHqK9trMPusFg8G365bFf0gRUl8
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Non-coding+RNAs+in+hepatocellular+carcinoma%3A+molecular+functions+and+pathological+implications&rft.jtitle=Nature+reviews.+Gastroenterology+%26+hepatology&rft.au=Wong%2C+Chun-Ming&rft.au=Tsang%2C+Felice+Ho-Ching&rft.au=Ng%2C+Irene+Oi-Lin&rft.date=2018-03-01&rft.pub=Nature+Publishing+Group&rft.issn=1759-5045&rft.volume=15&rft.issue=3&rft.spage=137&rft_id=info:doi/10.1038%2Fnrgastro.2017.169&rft.externalDocID=A528557397
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1759-5045&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1759-5045&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1759-5045&client=summon