Associations of Serum Retinol, α-Tocopherol, and γ-Tocopherol with Biomarkers among Healthy Japanese Men
Retinol, α-tocopherol, and γ-tocopherol are fat-soluble vitamins acting as antioxidants via the prevention of lipid oxidation. Little is known about circulatory levels in healthy individuals. The present cross-sectional study aimed at elucidating the relationship between these antioxidants and clini...
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| Published in | International journal of environmental research and public health Vol. 11; no. 2; pp. 1647 - 1660 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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30.01.2014
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| Abstract | Retinol, α-tocopherol, and γ-tocopherol are fat-soluble vitamins acting as antioxidants via the prevention of lipid oxidation. Little is known about circulatory levels in healthy individuals. The present cross-sectional study aimed at elucidating the relationship between these antioxidants and clinical biomarkers in 206 male (median age 41 years, range 23–67) employees from companies located in the Okayama Prefecture, Japan. Subjects younger than 40 years (n = 94) showed a positive association of the frequency of alcohol consumption with the circulating retinol (β = 0.344, p = 0.001) and γ-tocopherol levels (β = 0.219, p = 0.041), and an inverse association of fast insulin with serum retinol (β = −0.301, p = 0.009). In participants older than 40 years (n = 112) we found that an inverse association of HOMA-R with serum retinol (β = −0.262, p = 0.021), α-tocopherol (β = −0.236, p = 0.035), and γ-tocopherol levels (β = −0.224, p = 0.052); and cigarette smoking was inversely associated with the levels of serum α-tocopherol (β = −0.286, p = 0.008) and γ-tocopherol (β = −0.229, p = 0.040). We further found negative relationships between serum ferritin and the retinol (β = −0.211, p = 0.032) and α-tocopherol levels (β = −0.223, p = 0.022) in men over 40 years of age. The present study suggests that the circulatory levels of antioxidant vitamins may modulate the action of insulin and that higher levels of iron might decrease the levels of antioxidant vitamins in the blood. |
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| AbstractList | Retinol, α-tocopherol, and γ-tocopherol are fat-soluble vitamins acting as antioxidants via the prevention of lipid oxidation. Little is known about circulatory levels in healthy individuals. The present cross-sectional study aimed at elucidating the relationship between these antioxidants and clinical biomarkers in 206 male (median age 41 years, range 23-67) employees from companies located in the Okayama Prefecture, Japan. Subjects younger than 40 years (n = 94) showed a positive association of the frequency of alcohol consumption with the circulating retinol (β = 0.344, p = 0.001) and γ-tocopherol levels (β = 0.219, p = 0.041), and an inverse association of fast insulin with serum retinol (β = -0.301, p = 0.009). In participants older than 40 years (n = 112) we found that an inverse association of HOMA-R with serum retinol (β = -0.262, p = 0.021), α-tocopherol (β = -0.236, p = 0.035), and γ-tocopherol levels (β = -0.224, p = 0.052); and cigarette smoking was inversely associated with the levels of serum α-tocopherol (β = -0.286, p = 0.008) and γ-tocopherol (β = -0.229, p = 0.040). We further found negative relationships between serum ferritin and the retinol (β = -0.211, p = 0.032) and α-tocopherol levels (β = -0.223, p = 0.022) in men over 40 years of age. The present study suggests that the circulatory levels of antioxidant vitamins may modulate the action of insulin and that higher levels of iron might decrease the levels of antioxidant vitamins in the blood.Retinol, α-tocopherol, and γ-tocopherol are fat-soluble vitamins acting as antioxidants via the prevention of lipid oxidation. Little is known about circulatory levels in healthy individuals. The present cross-sectional study aimed at elucidating the relationship between these antioxidants and clinical biomarkers in 206 male (median age 41 years, range 23-67) employees from companies located in the Okayama Prefecture, Japan. Subjects younger than 40 years (n = 94) showed a positive association of the frequency of alcohol consumption with the circulating retinol (β = 0.344, p = 0.001) and γ-tocopherol levels (β = 0.219, p = 0.041), and an inverse association of fast insulin with serum retinol (β = -0.301, p = 0.009). In participants older than 40 years (n = 112) we found that an inverse association of HOMA-R with serum retinol (β = -0.262, p = 0.021), α-tocopherol (β = -0.236, p = 0.035), and γ-tocopherol levels (β = -0.224, p = 0.052); and cigarette smoking was inversely associated with the levels of serum α-tocopherol (β = -0.286, p = 0.008) and γ-tocopherol (β = -0.229, p = 0.040). We further found negative relationships between serum ferritin and the retinol (β = -0.211, p = 0.032) and α-tocopherol levels (β = -0.223, p = 0.022) in men over 40 years of age. The present study suggests that the circulatory levels of antioxidant vitamins may modulate the action of insulin and that higher levels of iron might decrease the levels of antioxidant vitamins in the blood. Retinol, α-tocopherol, and γ-tocopherol are fat-soluble vitamins acting as antioxidants via the prevention of lipid oxidation. Little is known about circulatory levels in healthy individuals. The present cross-sectional study aimed at elucidating the relationship between these antioxidants and clinical biomarkers in 206 male (median age 41 years, range 23–67) employees from companies located in the Okayama Prefecture, Japan. Subjects younger than 40 years (n = 94) showed a positive association of the frequency of alcohol consumption with the circulating retinol (β = 0.344, p = 0.001) and γ-tocopherol levels (β = 0.219, p = 0.041), and an inverse association of fast insulin with serum retinol (β = −0.301, p = 0.009). In participants older than 40 years (n = 112) we found that an inverse association of HOMA-R with serum retinol (β = −0.262, p = 0.021), α-tocopherol (β = −0.236, p = 0.035), and γ-tocopherol levels (β = −0.224, p = 0.052); and cigarette smoking was inversely associated with the levels of serum α-tocopherol (β = −0.286, p = 0.008) and γ-tocopherol (β = −0.229, p = 0.040). We further found negative relationships between serum ferritin and the retinol (β = −0.211, p = 0.032) and α-tocopherol levels (β = −0.223, p = 0.022) in men over 40 years of age. The present study suggests that the circulatory levels of antioxidant vitamins may modulate the action of insulin and that higher levels of iron might decrease the levels of antioxidant vitamins in the blood. Retinol, α-tocopherol, and γ-tocopherol are fat-soluble vitamins acting as antioxidants via the prevention of lipid oxidation. Little is known about circulatory levels in healthy individuals. The present cross-sectional study aimed at elucidating the relationship between these antioxidants and clinical biomarkers in 206 male (median age 41 years, range 23-67) employees from companies located in the Okayama Prefecture, Japan. Subjects younger than 40 years (n = 94) showed a positive association of the frequency of alcohol consumption with the circulating retinol (β = 0.344, p = 0.001) and γ-tocopherol levels (β = 0.219, p = 0.041), and an inverse association of fast insulin with serum retinol (β = -0.301, p = 0.009). In participants older than 40 years (n = 112) we found that an inverse association of HOMA-R with serum retinol (β = -0.262, p = 0.021), α-tocopherol (β = -0.236, p = 0.035), and γ-tocopherol levels (β = -0.224, p = 0.052); and cigarette smoking was inversely associated with the levels of serum α-tocopherol (β = -0.286, p = 0.008) and γ-tocopherol (β = -0.229, p = 0.040). We further found negative relationships between serum ferritin and the retinol (β = -0.211, p = 0.032) and α-tocopherol levels (β = -0.223, p = 0.022) in men over 40 years of age. The present study suggests that the circulatory levels of antioxidant vitamins may modulate the action of insulin and that higher levels of iron might decrease the levels of antioxidant vitamins in the blood. Retinol, α-tocopherol, and γ-tocopherol are fat-soluble vitamins acting as antioxidants via the prevention of lipid oxidation. Little is known about circulatory levels in healthy individuals. The present cross-sectional study aimed at elucidating the relationship between these antioxidants and clinical biomarkers in 206 male (median age 41 years, range 23–67) employees from companies located in the Okayama Prefecture, Japan. Subjects younger than 40 years (n = 94) showed a positive association of the frequency of alcohol consumption with the circulating retinol (β = 0.344, p = 0.001) and γ-tocopherol levels (β = 0.219, p = 0.041), and an inverse association of fast insulin with serum retinol (β = −0.301, p = 0.009). In participants older than 40 years (n = 112) we found that an inverse association of HOMA-R with serum retinol (β = −0.262, p = 0.021), α-tocopherol (β = −0.236, p = 0.035), and γ-tocopherol levels (β = −0.224, p = 0.052); and cigarette smoking was inversely associated with the levels of serum α-tocopherol (β = −0.286, p = 0.008) and γ-tocopherol (β = −0.229, p = 0.040). We further found negative relationships between serum ferritin and the retinol (β = −0.211, p = 0.032) and α-tocopherol levels (β = −0.223, p = 0.022) in men over 40 years of age. The present study suggests that the circulatory levels of antioxidant vitamins may modulate the action of insulin and that higher levels of iron might decrease the levels of antioxidant vitamins in the blood. Retinol, alpha -tocopherol, and gamma -tocopherol are fat-soluble vitamins acting as antioxidants via the prevention of lipid oxidation. Little is known about circulatory levels in healthy individuals. The present cross-sectional study aimed at elucidating the relationship between these antioxidants and clinical biomarkers in 206 male (median age 41 years, range 23-67) employees from companies located in the Okayama Prefecture, Japan. Subjects younger than 40 years (n = 94) showed a positive association of the frequency of alcohol consumption with the circulating retinol ( beta = 0.344, p = 0.001) and gamma -tocopherol levels ( beta = 0.219, p = 0.041), and an inverse association of fast insulin with serum retinol ( beta = -0.301, p = 0.009). In participants older than 40 years (n = 112) we found that an inverse association of HOMA-R with serum retinol ( beta = -0.262, p = 0.021), alpha -tocopherol ( beta = -0.236, p = 0.035), and gamma -tocopherol levels ( beta = -0.224, p = 0.052); and cigarette smoking was inversely associated with the levels of serum alpha -tocopherol ( beta = -0.286, p = 0.008) and gamma -tocopherol ( beta = -0.229, p = 0.040). We further found negative relationships between serum ferritin and the retinol ( beta = -0.211, p = 0.032) and alpha -tocopherol levels ( beta = -0.223, p = 0.022) in men over 40 years of age. The present study suggests that the circulatory levels of antioxidant vitamins may modulate the action of insulin and that higher levels of iron might decrease the levels of antioxidant vitamins in the blood. |
| Author | Zou, Yu Wang, Da-Hong Sakano, Noriko Sato, Yoshie Masatomi, Chie Taketa, Kazuhisa Iwanaga, Suketaka Ogino, Keiki Takemoto, Kei Inoue, Kiyomi Kubo, Masayuki |
| AuthorAffiliation | 3 Graduate School of Health Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan; E-Mail: yoshie@md.okayama-u.ac.jp 1 Department of Public Health, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan; E-Mails: rainyjo333@gmail.com (Y.Z.); masakubo@cc.okayama-u.ac.jp (M.K.); kei_takemoto@okayama-u.ac.jp (K.T.); ma.sa.chi.n.0409@gmail.com (C.M.); kogino@md.okayama-u.ac.jp (K.O.) 2 Department of Gerontology Research, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan; E-Mail: snoriko@cc.okayama-u.ac.jp 6 Public Health Care Nursing, Department of Nursing, Faculty of Health Sciences, Kobe Tokiwa University, 2-6-2 Otani-cho, Kobe 653-0838, Japan; E-Mail: k-inoue@kobe-tokiwa.ac.jp 4 Department of Public Health, Faculty of Medicine, Kyoto University, Yoshida-Konoye-cho Sakyo-ku, Kyoto 606-8501, Japan; E-Mail: iwanaga.at.wo |
| AuthorAffiliation_xml | – name: 3 Graduate School of Health Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan; E-Mail: yoshie@md.okayama-u.ac.jp – name: 6 Public Health Care Nursing, Department of Nursing, Faculty of Health Sciences, Kobe Tokiwa University, 2-6-2 Otani-cho, Kobe 653-0838, Japan; E-Mail: k-inoue@kobe-tokiwa.ac.jp – name: 1 Department of Public Health, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan; E-Mails: rainyjo333@gmail.com (Y.Z.); masakubo@cc.okayama-u.ac.jp (M.K.); kei_takemoto@okayama-u.ac.jp (K.T.); ma.sa.chi.n.0409@gmail.com (C.M.); kogino@md.okayama-u.ac.jp (K.O.) – name: 5 Geriatric Health Service Facility, Niwanosato Home, Mihara, Hiroshima 729-1321, Japan; E-Mail: taketa@rijinkai.or.jp – name: 2 Department of Gerontology Research, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan; E-Mail: snoriko@cc.okayama-u.ac.jp – name: 4 Department of Public Health, Faculty of Medicine, Kyoto University, Yoshida-Konoye-cho Sakyo-ku, Kyoto 606-8501, Japan; E-Mail: iwanaga.at.work@gmail.com |
| Author_xml | – sequence: 1 givenname: Yu surname: Zou fullname: Zou, Yu – sequence: 2 givenname: Da-Hong surname: Wang fullname: Wang, Da-Hong – sequence: 3 givenname: Noriko surname: Sakano fullname: Sakano, Noriko – sequence: 4 givenname: Yoshie surname: Sato fullname: Sato, Yoshie – sequence: 5 givenname: Suketaka surname: Iwanaga fullname: Iwanaga, Suketaka – sequence: 6 givenname: Kazuhisa surname: Taketa fullname: Taketa, Kazuhisa – sequence: 7 givenname: Masayuki surname: Kubo fullname: Kubo, Masayuki – sequence: 8 givenname: Kei surname: Takemoto fullname: Takemoto, Kei – sequence: 9 givenname: Chie surname: Masatomi fullname: Masatomi, Chie – sequence: 10 givenname: Kiyomi surname: Inoue fullname: Inoue, Kiyomi – sequence: 11 givenname: Keiki surname: Ogino fullname: Ogino, Keiki |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24487454$$D View this record in MEDLINE/PubMed |
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| Snippet | Retinol, α-tocopherol, and γ-tocopherol are fat-soluble vitamins acting as antioxidants via the prevention of lipid oxidation. Little is known about... Retinol, alpha -tocopherol, and gamma -tocopherol are fat-soluble vitamins acting as antioxidants via the prevention of lipid oxidation. Little is known about... |
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| SubjectTerms | Adult Aged alpha-Tocopherol - blood Antioxidants - metabolism Biomarkers - blood Cross-Sectional Studies Ferritins - blood gamma-Tocopherol - blood Humans Insulin - blood Male Middle Aged Reference Values Vitamin A - blood Young Adult |
| Title | Associations of Serum Retinol, α-Tocopherol, and γ-Tocopherol with Biomarkers among Healthy Japanese Men |
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