Identification of somatic mutations in monozygotic twins discordant for psychiatric disorders

• Published in: NPJ schizophrenia Vol. 4; no. 1; p. 7
• Main Authors: Nishioka, Masaki, Bundo, Miki, Ueda, Junko, Yoshikawa, Akane, Nishimura, Fumichika, Sasaki, Tsukasa, Kakiuchi, Chihiro, Kasai, Kiyoto, Kato, Tadafumi, Iwamoto, Kazuya
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.04.2018; Nature Publishing Group
• Subjects: 631/136; 692/699/476/1761; 692/699/476/1799; Behavior disorders; Cognitive Psychology; Medicine; Medicine & Public Health; Mental disorders; Mutation; Neurology; Neurosciences; Psychiatry; Twins

Monozygotic twins are assumed to have identical genomes. Based on this assumption, phenotypic discordance in monozygotic twins has been previously attributed to environmental factors. However, recent genomic studies have identified characteristic somatic mutations in monozygotic twins discordant for...