Free water elimination improves test–retest reproducibility of diffusion tensor imaging indices in the brain: A longitudinal multisite study of healthy elderly subjects

• Published in: Human brain mapping Vol. 38; no. 1; pp. 12 - 26
• Main Authors: Albi, Angela, Pasternak, Ofer, Minati, Ludovico, Marizzoni, Moira, Bartrés‐Faz, David, Bargalló, Núria, Bosch, Beatriz, Rossini, Paolo Maria, Marra, Camillo, Müller, Bernhard, Fiedler, Ute, Wiltfang, Jens, Roccatagliata, Luca, Picco, Agnese, Nobili, Flavio Mariano, Blin, Oliver, Sein, Julien, Ranjeva, Jean‐Philippe, Didic, Mira, Bombois, Stephanie, Lopes, Renaud, Bordet, Régis, Gros‐Dagnac, Hélène, Payoux, Pierre, Zoccatelli, Giada, Alessandrini, Franco, Beltramello, Alberto, Ferretti, Antonio, Caulo, Massimo, Aiello, Marco, Cavaliere, Carlo, Soricelli, Andrea, Parnetti, Lucilla, Tarducci, Roberto, Floridi, Piero, Tsolaki, Magda, Constantinidis, Manos, Drevelegas, Antonios, Frisoni, Giovanni, Jovicich, Jorge
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.01.2017; Wiley; John Wiley and Sons Inc
• Subjects: Aged; Aged, 80 and over; Aging; Anisotropy; Bioengineering; Brain - diagnostic imaging; Computer Science; Diffusion Tensor Imaging; Female; Healthy Volunteers; Humans; Imaging; Imaging, Three-Dimensional; Life Sciences; Longitudinal Studies; Male; Medical Imaging; Middle Aged; Reproducibility of Results; Water - metabolism; White Matter - diagnostic imaging; free-water imaging; brain diffusion tensor imaging; longitudinal; healthy elderly; multisite diffusion MRI; test-retest reproducibility; MRI; substantia-nigra; reliability; Schizophrenia; parkinsons-disease; snc; tracking; cerebral white-matter; spatial statistics; false discovery rate; alzheimers-disease

Free water elimination (FWE) in brain diffusion MRI has been shown to improve tissue specificity in human white matter characterization both in health and in disease. Relative to the classical diffusion tensor imaging (DTI) model, FWE is also expected to increase sensitivity to microstructural chang...