How tumours escape mass destruction

• Published in: Oncogene Vol. 27; no. 45; pp. 5894 - 5903
• Main Authors: Stewart, T J, Abrams, S I
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.10.2008; Nature Publishing Group
• Subjects: Animal models; Animals; Apoptosis; Cancer cells; Carcinogenesis; Cell Adhesion - immunology; Cell Adhesion - physiology; Cell Biology; Cell Communication - immunology; Cell Communication - physiology; Cell-mediated immunity; Cellular biology; Cellular immunity; Control; Genetic aspects; Genetics; Health aspects; Human Genetics; Humans; Immune response; Immune system; Immune Tolerance - immunology; Immune Tolerance - physiology; Immunology; Immunosuppression; Immunosurveillance; Immunotherapy; Internal Medicine; Medicine; Medicine & Public Health; Microenvironments; Models, Biological; Neoplasms - immunology; Oncology; review; Tumor Escape - immunology; Tumor Escape - physiology; Tumors; United States; tumour escape; immunosuppression; tumour microenvironment; tumour immunity; immunosurveillance

It is now well established that the immune system can control neoplastic development and growth in a process termed immunosurveillance. A link between host immunosurveillance and neoplastic progression is revealed in cases where the immune response becomes compromised due to genetic or other patholo...