Ferroptosis involves in intestinal epithelial cell death in ulcerative colitis

• Published in: Cell death & disease Vol. 11; no. 2; p. 86
• Main Authors: Xu, Minyi, Tao, Jin, Yang, Yidong, Tan, Siwei, Liu, Huiling, Jiang, Jie, Zheng, Fengping, Wu, Bin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.02.2020; Springer Nature B.V
• Subjects: 13/1; 13/21; 13/31; 13/51; 13/95; 14/35; 38/61; 38/90; 631/337; 64/60; 692/699/1503/1501; Animals; Antibodies; Apoptosis; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Culture; Cell death; Clonal deletion; Colitis, Ulcerative - genetics; Colitis, Ulcerative - metabolism; Colitis, Ulcerative - pathology; Colon; Dextran; Dextran sulfate; Endoplasmic reticulum; Endoplasmic Reticulum Stress; Epithelial cells; Eukaryotic Initiation Factor-2 - metabolism; Ferroptosis; Ferroptosis - genetics; Gene expression; Humans; Immunology; Inflammatory bowel disease; Intestinal Mucosa - metabolism; Intestinal Mucosa - pathology; Intestine; Life Sciences; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mucosa; Phosphorylation; Protein Binding; Signal Transduction; Therapeutic applications; Transcription Factor RelA - genetics; Transcription Factor RelA - metabolism; Tumor suppression; Ulcerative colitis

Ferroptosis has recently emerged as an iron-dependent form of nonapoptotic cell death, which is also a regulated necrosis process and a response to tumor suppression. However, whether ferroptosis is involved in ulcerative colitis (UC) is unknown. The aims of this study were to investigate whether th...