Causal relationship between rheumatoid arthritis and bronchiectasis: a bidirectional mendelian randomization study

• Published in: Arthritis research & therapy Vol. 26; no. 1; pp. 104 - 7
• Main Authors: Chen, Zehu, Li, Xuegang, Shi, Honglei, Huang, Yiying, Liu, Jing
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 23.05.2024; BioMed Central; BMC
• Subjects: Arthritis, Rheumatoid - epidemiology; Arthritis, Rheumatoid - genetics; Bronchiectasis; Bronchiectasis - epidemiology; Bronchiectasis - genetics; Causality; Complications and side effects; East Asian People - genetics; Ethnicity; Genetic aspects; Genetic Predisposition to Disease; Genetic susceptibility; Genome-wide association study; Health aspects; Humans; Medical research; Medicine, Experimental; Mendelian randomization; Mendelian Randomization Analysis - methods; Polymorphism, Single Nucleotide; Rheumatoid arthritis; Risk Factors; Single-nucleotide polymorphisms; White People - genetics; China; Single-nucleotide polymorphisms; Bronchiectasis; Mendelian randomization; Genome-wide association study; Rheumatoid arthritis

Epidemiological observational studies have elucidated a correlation between rheumatoid arthritis (RA) and bronchiectasis. However, the causal nature of this association remains ambiguous. To clarify this potential causal linkage, we conducted a two-sample Mendelian randomization (MR) analysis to exp...