Soft fibrin matrix downregulates DAB2IP to promote Nanog-dependent growth of colon tumor-repopulating cells

• Published in: Cell death & disease Vol. 10; no. 3; p. 151
• Main Authors: Zhang, Meng, Xu, Cong, Wang, Hai-zhou, Peng, Ya-nan, Li, Hai-ou, Zhou, Yun-jiao, Liu, Shi, Wang, Fan, Liu, Lan, Chang, Ying, Zhao, Qiu, Liu, Jing
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.02.2019; Springer Nature B.V
• Subjects: 1-Phosphatidylinositol 3-kinase; 13/1; 13/100; 13/109; 13/31; 13/51; 13/89; 14/34; 14/63; 45/77; 631/67/70; 631/67/71; 64/60; Animals; Antibodies; Apoptosis - drug effects; Apoptosis - genetics; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Culture; Cell Proliferation - drug effects; Cell self-renewal; Colon cancer; Colonic Neoplasms - metabolism; Colonic Neoplasms - pathology; Colonies; Colorectal cancer; Colorectal carcinoma; Extracellular matrix; Fibrin; Fibrin - metabolism; Fibrin - pharmacology; Gels; Gels - metabolism; Gels - pharmacology; HCT116 Cells; Hepatocyte Nuclear Factor 3-alpha - metabolism; Heterografts; HT29 Cells; Humans; Immunology; Life Sciences; Metastases; Mice; Mice, Inbred BALB C; Mice, Nude; Nanog Homeobox Protein - genetics; Nanog Homeobox Protein - metabolism; Neoplastic Stem Cells - metabolism; Phosphatidylinositol 3-Kinases - metabolism; ras GTPase-Activating Proteins - genetics; ras GTPase-Activating Proteins - metabolism; Salmon; siRNA; Stem cells; Stroma; Transfection; Tumorigenicity

Colon cancer stem cells (CSCs) have been shown to be responsible for the recurrence and metastasis of colorectal cancer (CRC). As a crucial microenvironmental factor, extracellular matrix (ECM) stiffness is known to affect the stemness of CSCs. Recently, fibrin deposition in the stroma of CRC was de...