Genetic Alterations in Esophageal Tissues From Squamous Dysplasia to Carcinoma

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 153; no. 1; pp. 166 - 177
• Main Authors: Liu, Xi, Zhang, Min, Ying, Songmin, Zhang, Chong, Lin, Runhua, Zheng, Jiaxuan, Zhang, Guohong, Tian, Dongping, Guo, Yi, Du, Caiwen, Chen, Yuping, Chen, Shaobin, Su, Xue, Ji, Juan, Deng, Wanting, Li, Xiang, Qiu, Shiyue, Yan, Ruijing, Xu, Zexin, Wang, Yuan, Guo, Yuanning, Cui, Jiancheng, Zhuang, Shanshan, Yu, Huan, Zheng, Qi, Marom, Moshe, Sheng, Sitong, Zhang, Guoqiang, Hu, Songnian, Li, Ruiqiang, Su, Min
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2017
• Subjects: APOBEC Deaminases - genetics; Apoptosis - genetics; Carcinogenesis; Carcinoma in Situ - genetics; Carcinoma, Squamous Cell - genetics; Cell Adhesion - genetics; Cell Proliferation - genetics; Chromosomes, Human, Pair 11 - genetics; Chromosomes, Human, Pair 2 - genetics; Chromosomes, Human, Pair 3 - genetics; Chromosomes, Human, Pair 9 - genetics; Cyclin-Dependent Kinase Inhibitor p18 - genetics; DNA Copy Number Variations; DNA Mutational Analysis; DNA Repair - genetics; Driver Mutation; Esophageal Neoplasms - genetics; Esophagitis - metabolism; Esophagitis - pathology; Esophagus; Esophagus - metabolism; Esophagus - pathology; Gastroenterology and Hepatology; High-Throughput Nucleotide Sequencing; Humans; Hyperplasia - genetics; NF-E2-Related Factor 2 - genetics; Phylogeny; Sequencing; SOXB1 Transcription Factors - genetics; Tumor Suppressor Protein p53 - genetics; WGS; ESSH; LOH; WES; EAC; Carcinogenesis; ESCC; Esophagus; IEN; TRS; γH2AX; APOBEC; CNA; Driver Mutation; Sequencing; gDNA; intraepithelial neoplasia; copy number alteration; phosphorylated H2AX; targeted sequencing; loss of heterozygosity; esophageal squamous cell carcinoma; genomic DNA; whole-genome sequencing; apolipoprotein B messenger RNA editing enzyme, catalytic polypeptide-like; esophageal adenocarcinoma; esophageal squamous simple hyperplasia; whole-exome sequencing

Esophageal squamous cell carcinoma (ESCC) is the most common subtype of esophageal cancer. Little is known about the genetic changes that occur in esophageal cells during the development of ESCC. We performed next-generation sequence analyses of esophageal nontumor, intraepithelial neoplasia (IEN),...