ROS-independent ER stress-mediated NRF2 activation promotes warburg effect to maintain stemness-associated properties of cancer-initiating cells

• Published in: Cell death & disease Vol. 9; no. 2; pp. 194 - 14
• Main Authors: Chang, Ching-Wen, Chen, Yu-Syuan, Tsay, Yeou-Guang, Han, Chia-Li, Chen, Yu-Ju, Yang, Cheng-Chieh, Hung, Kai-Feng, Lin, Chao-Hsiung, Huang, Tsung-Yen, Kao, Shou-Yen, Lee, Te-Chang, Lo, Jeng-Fan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.02.2018; Springer Nature B.V
• Subjects: 13/31; 14/19; 38/61; 38/91; 42/89; 82/58; Antibodies; Antioxidants; Biochemistry; Biomedical and Life Sciences; Cancer; Cell Biology; Cell Culture; Glycolysis; Homeostasis; Immunology; Intracellular; Kinases; Life Sciences; Metabolism; Oxidative stress; Pyruvic acid; Reactive oxygen species; Transcription; Tricarboxylic acid cycle

Cancer-initiating cells (CICs) are responsible for tumor initiation, progression, and therapeutic resistance; moreover, redox homeostasis is important in regulating cancer stemness. Previously, we have identified that cancer cells containing low intracellular reactive oxygen species levels (ROS Low...