Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy

• Published in: Nature reviews. Neurology Vol. 15; no. 8; pp. 459 - 472
• Main Authors: Vezzani, Annamaria, Balosso, Silvia, Ravizza, Teresa
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.08.2019; Nature Publishing Group
• Subjects: 631/80/304; 692/308/575; 692/420/256; 692/699/375/178; Animals; Arachidonic Acid - metabolism; Biological markers; Biomarkers; Biomarkers - blood; Brain; Cellular signal transduction; Convulsions & seizures; Development and progression; Diagnosis; Drug resistance; Drug therapy; Encephalitis - complications; Encephalitis - diagnosis; Encephalitis - metabolism; Epilepsy; Epilepsy - complications; Epilepsy - diagnosis; Epilepsy - metabolism; Epilepsy - therapy; Growth factors; Humans; Inflammation; Medicine; Medicine & Public Health; Neurological research; Neurology; Oxidative Stress; Prostaglandins - metabolism; Receptors, Interleukin-1 - metabolism; Review Article; Signal Transduction; Toll-Like Receptor 4 - metabolism; Transforming Growth Factor beta - metabolism; Italy

Epilepsy is a chronic neurological disease characterized by an enduring propensity for generation of seizures. The pathogenic processes of seizure generation and recurrence are the subject of intensive preclinical and clinical investigations as their identification would enable development of novel...