Enzymatic Properties of Squalene Epoxidase from Saccharomyces cerevisiae

• Published in: Biological & pharmaceutical bulletin Vol. 16; no. 4; pp. 349 - 352
• Main Authors: SATOH, Toshihiko, HORIE, Masahiro, WATANABE, Hisako, TSUCHIYA, Yoshimi, KAMEI, Toshio
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 01.04.1993; Maruzen; Japan Science and Technology Agency
• Subjects: Analytical, structural and metabolic biochemistry; Animals; Benzylamines - pharmacology; Biological and medical sciences; Candida albicans - enzymology; Enzyme Inhibitors - pharmacology; Enzymes and enzyme inhibitors; Flavin-Adenine Dinucleotide - metabolism; Fundamental and applied biological sciences. Psychology; Fungal Proteins - metabolism; Hydrogen-Ion Concentration; Kinetics; Microsomes - enzymology; NADP - metabolism; Naphthalenes - pharmacology; NB-598; Octoxynol; Oxidoreductases; Oxygenases - antagonists & inhibitors; Oxygenases - metabolism; Polyethylene Glycols - pharmacology; Rats; Saccharomyces cerevisiae; Saccharomyces cerevisiae - enzymology; Species Specificity; squalene epoxidase; squalene epoxidase inhbitor; Squalene Monooxygenase; Terbinafine; Thiophenes - pharmacology; Fungi; Squalene monooxygenase (2,3-epoxidizing); Enzymatic activity; Microbial origin; Enzyme; Ascomycetes; Species specificity; Kinetic parameter; Saccharomyces cerevisiae; Thallophyta

Squalene epoxidase is a microsomal membrane-associated enzyme that acts as an important regulator in the sterol biosynthetic pathway. In this study, the enzymatic properties of squalene epoxidase from Saccharomyces cerevisiae were examined. Unlike Candida squalene epoxidase, S. cerevisiae squalene e...