Brain ferritin iron may influence age- and gender-related risks of neurodegeneration

Abstract Background Brain iron promotes oxidative damage and protein oligomerization that result in highly prevalent age-related proteinopathies such as Alzheimer's disease (AD), Parkinson's disease (PD), and Dementia with Lewy Bodies (DLB). Men are more likely to develop such diseases at...

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Published inNeurobiology of aging Vol. 28; no. 3; pp. 414 - 423
Main Authors Bartzokis, George, Tishler, Todd A, Lu, Po H, Villablanca, Pablo, Altshuler, Lori L, Carter, Michele, Huang, Danny, Edwards, Nancy, Mintz, Jim
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.03.2007
Subjects
Adult
Age
Aged
Aged, 80 and over
Aging
Brain
Brain - metabolism
Dementia
FDRI
Female
Ferritin
Ferritins - chemistry
Ferritins - metabolism
Free radicals
Frontal lobe
Gender
Hemochromatosis
Hippocampus
Humans
Image Processing, Computer-Assisted - methods
Internal Medicine
Iron
Iron - metabolism
Magnetic Resonance Imaging - methods
Male
Middle Aged
MRI
Myelin
Nerve Degeneration - pathology
Neurodegeneration
Neurology
Oligodendrocytes
Onset
Postmortem Changes
Prevention
Proteinopathy
Risk
Sex
Sex Characteristics
Treatment
White matter
Brain
Proteinopathy
Frontal lobe
Hemochromatosis
Free radicals
MRI
Myelin
Ferritin
Sex
Risk
Iron
Gender
White matter
Onset
Prevention
Treatment
FDRI
Neurodegeneration
Oligodendrocytes
Age
Hippocampus
Dementia
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Abstract Abstract Background Brain iron promotes oxidative damage and protein oligomerization that result in highly prevalent age-related proteinopathies such as Alzheimer's disease (AD), Parkinson's disease (PD), and Dementia with Lewy Bodies (DLB). Men are more likely to develop such diseases at earlier ages than women but brain iron levels increase with age in both genders. We hypothesized that brain iron may influence both the age- and gender-related risks of developing these diseases. Methods The amount of iron in ferritin molecules (ferritin iron) was measured in vivo with MRI by utilizing the field dependent relaxation rate increase (FDRI) method. Ferritin iron was measured in four subcortical nuclei [caudate (C), putamen (P), globus pallidus (G), thalamus (T)], three white matter regions [frontal lobe (Fwm), genu and splenium of the corpus callosum (Gwm, Swm)] and hippocampus (Hipp) in 165 healthy adults aged 19–82. Results There was a high correlation ( r > 0.99) between published post-mortem brain iron levels and FDRI. There were significant age-related changes in ferritin iron (increases in Hipp, C, P, G, and decreases in Fwm). Women had significantly lower ferritin iron than men in five regions (C, T, Fwm, Gwm, Swm). Conclusions This is the first demonstration of gender differences in brain ferritin iron levels. It is possible that brain iron accumulation is a risk factor that can be modified. MRI provides the opportunity to assess brain iron levels in vivo and may be useful in targeting individuals or groups for preventive therapeutic interventions.
AbstractList Brain iron promotes oxidative damage and protein oligomerization that result in highly prevalent age-related proteinopathies such as Alzheimer's disease (AD), Parkinson's disease (PD), and Dementia with Lewy Bodies (DLB). Men are more likely to develop such diseases at earlier ages than women but brain iron levels increase with age in both genders. We hypothesized that brain iron may influence both the age- and gender-related risks of developing these diseases. The amount of iron in ferritin molecules (ferritin iron) was measured in vivo with MRI by utilizing the field dependent relaxation rate increase (FDRI) method. Ferritin iron was measured in four subcortical nuclei [caudate (C), putamen (P), globus pallidus (G), thalamus (T)], three white matter regions [frontal lobe (Fwm), genu and splenium of the corpus callosum (Gwm, Swm)] and hippocampus (Hipp) in 165 healthy adults aged 19-82. There was a high correlation (r>0.99) between published post-mortem brain iron levels and FDRI. There were significant age-related changes in ferritin iron (increases in Hipp, C, P, G, and decreases in Fwm). Women had significantly lower ferritin iron than men in five regions (C, T, Fwm, Gwm, Swm). This is the first demonstration of gender differences in brain ferritin iron levels. It is possible that brain iron accumulation is a risk factor that can be modified. MRI provides the opportunity to assess brain iron levels in vivo and may be useful in targeting individuals or groups for preventive therapeutic interventions.
BACKGROUNDBrain iron promotes oxidative damage and protein oligomerization that result in highly prevalent age-related proteinopathies such as Alzheimer's disease (AD), Parkinson's disease (PD), and Dementia with Lewy Bodies (DLB). Men are more likely to develop such diseases at earlier ages than women but brain iron levels increase with age in both genders. We hypothesized that brain iron may influence both the age- and gender-related risks of developing these diseases.METHODSThe amount of iron in ferritin molecules (ferritin iron) was measured in vivo with MRI by utilizing the field dependent relaxation rate increase (FDRI) method. Ferritin iron was measured in four subcortical nuclei [caudate (C), putamen (P), globus pallidus (G), thalamus (T)], three white matter regions [frontal lobe (Fwm), genu and splenium of the corpus callosum (Gwm, Swm)] and hippocampus (Hipp) in 165 healthy adults aged 19-82.RESULTSThere was a high correlation (r>0.99) between published post-mortem brain iron levels and FDRI. There were significant age-related changes in ferritin iron (increases in Hipp, C, P, G, and decreases in Fwm). Women had significantly lower ferritin iron than men in five regions (C, T, Fwm, Gwm, Swm).CONCLUSIONSThis is the first demonstration of gender differences in brain ferritin iron levels. It is possible that brain iron accumulation is a risk factor that can be modified. MRI provides the opportunity to assess brain iron levels in vivo and may be useful in targeting individuals or groups for preventive therapeutic interventions.
Abstract Background Brain iron promotes oxidative damage and protein oligomerization that result in highly prevalent age-related proteinopathies such as Alzheimer's disease (AD), Parkinson's disease (PD), and Dementia with Lewy Bodies (DLB). Men are more likely to develop such diseases at earlier ages than women but brain iron levels increase with age in both genders. We hypothesized that brain iron may influence both the age- and gender-related risks of developing these diseases. Methods The amount of iron in ferritin molecules (ferritin iron) was measured in vivo with MRI by utilizing the field dependent relaxation rate increase (FDRI) method. Ferritin iron was measured in four subcortical nuclei [caudate (C), putamen (P), globus pallidus (G), thalamus (T)], three white matter regions [frontal lobe (Fwm), genu and splenium of the corpus callosum (Gwm, Swm)] and hippocampus (Hipp) in 165 healthy adults aged 19–82. Results There was a high correlation ( r > 0.99) between published post-mortem brain iron levels and FDRI. There were significant age-related changes in ferritin iron (increases in Hipp, C, P, G, and decreases in Fwm). Women had significantly lower ferritin iron than men in five regions (C, T, Fwm, Gwm, Swm). Conclusions This is the first demonstration of gender differences in brain ferritin iron levels. It is possible that brain iron accumulation is a risk factor that can be modified. MRI provides the opportunity to assess brain iron levels in vivo and may be useful in targeting individuals or groups for preventive therapeutic interventions.
<span class="h4 Background Brain iron promotes oxidative damage and protein oligomerization that result in highly prevalent age-related proteinopathies such as Alzheimers disease (AD), Parkinsons disease (PD), and Dementia with Lewy Bodies (DLB). Men are more likely to develop such diseases at earlier ages than women but brain iron levels increase with age in both genders. We hypothesized that brain iron may influence both the age- and gender-related risks of developing these diseases. <span class="h4 Methods The amount of iron in ferritin molecules (ferritin iron) was measured in vivo with MRI by utilizing the field dependent relaxation rate increase (FDRI) method. Ferritin iron was measured in four subcortical nuclei [caudate (C), putamen (P), globus pallidus (G), thalamus (T)], three white matter regions [frontal lobe (Fwm), genu and splenium of the corpus callosum (Gwm, Swm)] and hippocampus (Hipp) in 165 healthy adults aged 19-82. <span class="h4 Results There was a high correlation (r > 0.99) between published post-mortem brain iron levels and FDRI. There were significant age-related changes in ferritin iron (increases in Hipp, C, P, G, and decreases in Fwm). Women had significantly lower ferritin iron than men in five regions (C, T, Fwm, Gwm, Swm). <span class="h4 Conclusions This is the first demonstration of gender differences in brain ferritin iron levels. It is possible that brain iron accumulation is a risk factor that can be modified. MRI provides the opportunity to assess brain iron levels in vivo and may be useful in targeting individuals or groups for preventive therapeutic interventions.
Brain iron promotes oxidative damage and protein oligomerization that result in highly prevalent age-related proteinopathies such as Alzheimer's disease (AD), Parkinson's disease (PD), and Dementia with Lewy Bodies (DLB). Men are more likely to develop such diseases at earlier ages than women but brain iron levels increase with age in both genders. We hypothesized that brain iron may influence both the age- and gender-related risks of developing these diseases. The amount of iron in ferritin molecules (ferritin iron) was measured in vivo with MRI by utilizing the field dependent relaxation rate increase (FDRI) method. Ferritin iron was measured in four subcortical nuclei [caudate (C), putamen (P), globus pallidus (G), thalamus (T)], three white matter regions [frontal lobe (Fwm), genu and splenium of the corpus callosum (Gwm, Swm)] and hippocampus (Hipp) in 165 healthy adults aged 19–82. There was a high correlation ( r > 0.99) between published post-mortem brain iron levels and FDRI. There were significant age-related changes in ferritin iron (increases in Hipp, C, P, G, and decreases in Fwm). Women had significantly lower ferritin iron than men in five regions (C, T, Fwm, Gwm, Swm). This is the first demonstration of gender differences in brain ferritin iron levels. It is possible that brain iron accumulation is a risk factor that can be modified. MRI provides the opportunity to assess brain iron levels in vivo and may be useful in targeting individuals or groups for preventive therapeutic interventions.
Author Villablanca, Pablo
Huang, Danny
Altshuler, Lori L
Lu, Po H
Bartzokis, George
Mintz, Jim
Tishler, Todd A
Carter, Michele
Edwards, Nancy
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  fullname: Bartzokis, George
– sequence: 2
  fullname: Tishler, Todd A
– sequence: 3
  fullname: Lu, Po H
– sequence: 4
  fullname: Villablanca, Pablo
– sequence: 5
  fullname: Altshuler, Lori L
– sequence: 6
  fullname: Carter, Michele
– sequence: 7
  fullname: Huang, Danny
– sequence: 8
  fullname: Edwards, Nancy
– sequence: 9
  fullname: Mintz, Jim
BackLink https://www.ncbi.nlm.nih.gov/pubmed/16563566$$D View this record in MEDLINE/PubMed
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Proteinopathy
Frontal lobe
Hemochromatosis
Free radicals
MRI
Myelin
Ferritin
Sex
Risk
Iron
Gender
White matter
Onset
Prevention
Treatment
FDRI
Neurodegeneration
Oligodendrocytes
Age
Hippocampus
Dementia
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Snippet Abstract Background Brain iron promotes oxidative damage and protein oligomerization that result in highly prevalent age-related proteinopathies such as...
Brain iron promotes oxidative damage and protein oligomerization that result in highly prevalent age-related proteinopathies such as Alzheimer's disease (AD),...
<span class="h4 Background Brain iron promotes oxidative damage and protein oligomerization that result in highly prevalent age-related proteinopathies such as...
BACKGROUNDBrain iron promotes oxidative damage and protein oligomerization that result in highly prevalent age-related proteinopathies such as Alzheimer's...
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SubjectTerms Adult
Age
Aged
Aged, 80 and over
Aging
Brain
Brain - metabolism
Dementia
FDRI
Female
Ferritin
Ferritins - chemistry
Ferritins - metabolism
Free radicals
Frontal lobe
Gender
Hemochromatosis
Hippocampus
Humans
Image Processing, Computer-Assisted - methods
Internal Medicine
Iron
Iron - metabolism
Magnetic Resonance Imaging - methods
Male
Middle Aged
MRI
Myelin
Nerve Degeneration - pathology
Neurodegeneration
Neurology
Oligodendrocytes
Onset
Postmortem Changes
Prevention
Proteinopathy
Risk
Sex
Sex Characteristics
Treatment
White matter
Title Brain ferritin iron may influence age- and gender-related risks of neurodegeneration
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https://dx.doi.org/10.1016/j.neurobiolaging.2006.02.005
https://www.ncbi.nlm.nih.gov/pubmed/16563566
https://search.proquest.com/docview/19635392
https://search.proquest.com/docview/68981040
Volume 28
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