Clinical and pharmacogenetic impact of endothelial nitric oxide synthase polymorphisms on cardiovascular diseases

• Published in: Nitric oxide Vol. 63; pp. 39 - 51
• Main Authors: Oliveira-Paula, Gustavo H., Lacchini, Riccardo, Tanus-Santos, Jose E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 28.02.2017
• Subjects: Cardiovascular Diseases - genetics; Endothelial nitric oxide synthase; Genetic polymorphisms; Haplotypes; Humans; Nitric oxide; Nitric Oxide Synthase Type III - genetics; NOS3 gene; Pharmacogenetics; Pharmacogenomic Variants; Polymorphism, Genetic; Haplotypes; Endothelial nitric oxide synthase; NOS3 gene; Pharmacogenetics; Nitric oxide; Genetic polymorphisms

Nitric oxide (NO) is a vasoactive substance synthesized from l-arginine by neuronal (NOS1), endothelial (NOS3), and inducible (NOS2) nitric oxide synthases. NOS3 is the most important NO synthase isoform in the vascular endothelium and therefore it exerts critical roles in the cardiovascular system....