Identification of novel peptides that stimulate human neutrophils

• Published in: Experimental & molecular medicine Vol. 44; no. 2; pp. 130 - 137
• Main Authors: Bae, Geon Ho, Lee, Ha Young, Jung, Young Su, Shim, Jae Woong, Kim, Sang Doo, Baek, Suk-Hwan, Kwon, Jae Young, Park, Joon Seong, Bae, Yoe-Sik
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.02.2012; Springer Nature B.V; Korean Society for Biochemistry and Molecular Biology; 생화학분자생물학회
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Calcium - metabolism; Cell Line; Cells, Cultured; Chemotaxis, Leukocyte - drug effects; Humans; Medical Biochemistry; Mice; Molecular Medicine; Neutrophils - cytology; Neutrophils - drug effects; NIH 3T3 Cells; Original; PC12 Cells; Peptides - pharmacology; Rats; Receptors, Formyl Peptide - agonists; Stem Cells; 생화학; peptides; calcium; receptors, formyl peptide; neutrophils; peptide library; chemotaxis

Neutrophils play a key role in innate immunity, and the identification of new stimuli that stimulate neutrophil activity is a very important issue. In this study, we identified three novel peptides by screening a synthetic hexapeptide combinatorial library. The identified peptides GMMWAI, MMHWAM, an...