Infectious pathogens may trigger specific allo-HLA reactivity via multiple mechanisms

• Published in: Immunogenetics (New York) Vol. 69; no. 8-9; pp. 631 - 641
• Main Authors: D’Orsogna, Lloyd, van den Heuvel, Heleen, van Kooten, Cees, Heidt, Sebastiaan, Claas, Frans H.J.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2017; Springer Nature B.V
• Subjects: Allergology; Antigen Presentation; Antigen-presenting cells; Antigens; B-Lymphocytes - immunology; Biomedical and Life Sciences; Biomedicine; Blood transfusion; Cell activation; Cell Biology; Cross Reactions; Cross-reactivity; Effectors; Exposure; Gene Function; Graft rejection; Herpesvirus 4, Human - immunology; Histocompatibility antigen HLA; HLA Antigens - immunology; Human Genetics; Humans; Immune response; Immune system; Immunity; Immunity, Innate; Immunologic Memory; Immunological memory; Immunology; Innate immunity; Lymphocyte Activation; Lymphocytes; Lymphocytes B; Lymphocytes T; Memory cells; Pathogens; Pregnancy; Receptors, Antigen, T-Cell - physiology; Rejection; Review; T cell receptors; T-Lymphocytes - immunology; Topical Collection on MHC/KIR in Health and Disease; Transplantation; Transplants & implants; Viruses; Infection; Alloreactivity; B cells; HLA; T cells; Heterologous immunity

Transplant recipients can be sensitized against allo-HLA antigens by previous transplantation, blood transfusion, or pregnancy. While there is growing awareness that multiple components of the immune system can act as effectors of the alloresponse, the role of infectious pathogen exposure in trigger...